Bisoctrizole (Tinosorb M) is a hybrid type sun blocking agent acting as both chemical and physical sunscreen. Bisoctrizole is a hybrid UV absorber, the only organic UV filter produced and microfine organic particles (< 200 nm), like microfine zinc oxide and titanium dioxide. Where other organic UV absorbers need to be dissolved in either the oil or water phase, bisoctrizole dissolves poorly in both. It covers both UVA and UVB range. Furthermore, it does not degrade under sunlight and is not significantly absorbed into the skin. It appear highly compatible with many other common sun blocking agents. Overall, it appears to have a good safety profile, even though current safety data are insufficient and long-term human safety studies are lacking. Unlike some other organic sunscreen actives, it shows no estrogenic effects in vitro. Bisoctrizole is not approved by the U.S. Food and Drug Administration (FDA), but is approved in the EU and other parts of the world. Bisoctrizole is highly stable and also has a stabilizing effect on other UV absorbers, particularly the UVB blocker octyl methoxycinnamate (octinoxate). Bisoctrizole appears to be relatively non-toxic and rarely causes skin irritation. As with many synthetic chemicals, it is unclear whether bisoctrizole may produce low-level skin damage or systemic effects with long-term use. Considering that bisoctrizole is stable, poorly soluble and minimally absorbed by the skin, the risks appear to be low. Still, more research is on bisoctrizole safety is needed.

MENTHYL SALICYLATE is an active component of COLD SPOT POINT RELIEF gel, which is indicated for temporary relief of minor aches and pains of the muscles and joints associated with simple backache, arthritis, bruises, strains and/or sprains.

Homosalate is used as a broad-band UV filter in concentrations of up to 10% in the EU or 15% depending upon where the product is used (e.g. in the USA) in sunscreen products alone or in combination with other UV absorbers to protect the skin against harmful effects of the UV radiation.

Octisalate used as an ingredient in sunscreens and cosmetics. Maximum FDA-approved concentration - 5%. Range of protection - UVB. Might develop contact allergic dermatitis

Mexenone is a benzophenone-derived UV absorbing compound used in sunscreen cosmetics such as creams, lotions, lipsticks and sun oils. It is not uncommon for Mexone and other related benzophenones to cause an allergic reaction when applied to the skin.

Bumetrizole is an ultraviolet light absorber (UVA) of the hydroxyphenyl benzotriazole class, which imparts outstanding light stability to plastics and other organic substrates. Bumetrizole is also approved by the FDA as a stabilizer in polymers used in producing, manufacturing, packaging, processing, and transporting food. Bumetrizole has a wide range of indirect food approvals in polyolefins. It has a low volatility at high temperatures and high resistance to thermal degradation and can, therefore, be used without significant loss or decomposition in the polyolefin compounding and molding processes.

Anethole trithione or anetholtrithione is a drug used in the treatment of dry mouth. Anethole trithione is a bile secretion-stimulating drug that restores salivation. It is listed in the U.S. National Cancer Institute's Dictionary of Cancer Terms as being studied in the treatment of cancer. Anethol has also been identified as a treatment for improving medium and severe dry eye symptoms. The mechanism of action for the chemopreventive and xerostomia properties have not been fully elucidated.

Bornelone (also known as Bornelon) is used as ultraviolet (UV) absorber, in order to protect include cosmetic products against the influence of ultraviolet light. Bornelone is not allowed as a UV filter in sunscreens in the Europe, as it was discovered, that in contact with the skin contact dermatitis could cause.

There is no available information related any biological and pharmaceutical application of ammonium tetrachlorozincate.

Sodium 3,4-dimethylphenylglyoxylate is a topical analgesic, sunscreen ingredient, UV-B absorber, FDA approved.