Details
Stereochemistry | MIXED |
Molecular Formula | C16H22O3 |
Molecular Weight | 262.3441 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 0 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1CC(CC(C)(C)C1)OC(=O)C2=C(O)C=CC=C2
InChI
InChIKey=WSSJONWNBBTCMG-UHFFFAOYSA-N
InChI=1S/C16H22O3/c1-11-8-12(10-16(2,3)9-11)19-15(18)13-6-4-5-7-14(13)17/h4-7,11-12,17H,8-10H2,1-3H3
DescriptionCurator's Comment: http://www.fda.gov/downloads/ForConsumers/ConsumerUpdates/UCM258718.pdf
Curator's Comment: http://www.fda.gov/downloads/ForConsumers/ConsumerUpdates/UCM258718.pdf
Homosalate is used as a broad-band UV filter in concentrations of up to 10% in the EU or 15% depending upon where the product is used (e.g. in the USA) in sunscreen products alone or in combination with other UV absorbers to protect the skin against harmful effects of the UV radiation.
Approval Year
PubMed
Title | Date | PubMed |
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Korean women: breast cancer knowledge, attitudes and behaviors. | 2001 |
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Determination of UV-filters in sunscreens by HPLC. | 2001 Apr |
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Comments on "In vitro and in vivo estrogenicity of UV screens". | 2001 Aug |
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Determination of the UV filters worldwide authorised in sunscreens by high-performance liquid chromatography. Use of cyclodextrins as mobile phase modifier. | 2001 Jul 6 |
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In vitro and in vivo estrogenicity of UV screens. | 2001 Mar |
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Filipina American women's breast cancer knowledge, attitudes, and screening behaviors. | 2003 Aug 15 |
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Skin penetration and sun protection factor of five UV filters: effect of the vehicle. | 2003 Jan-Feb |
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UV filters with antagonistic action at androgen receptors in the MDA-kb2 cell transcriptional-activation assay. | 2003 Jul |
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Liquid chromatographic assay for common sunscreen agents: application to in vivo assessment of skin penetration and systemic absorption in human volunteers. | 2004 Apr 25 |
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Active ingredients in sunscreens act as topical penetration enhancers for the herbicide 2,4-dichlorophenoxyacetic acid. | 2004 Mar 15 |
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Determination of sixteen UV filters in suncare formulations by high-performance liquid chromatography. | 2004 Sep 17 |
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Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. | 2005 Feb |
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Estrogenic activity of cosmetic components in reporter cell lines: parabens, UV screens, and musks. | 2005 Feb 27 |
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Spectroscopic and photochemical properties of the lichen compound lobaric acid. | 2005 Nov-Dec |
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Influence of anatomical site and topical formulation on skin penetration of sunscreens. | 2005 Sep |
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3,3,5-Trimethylcyclohexanols and derived esters: green synthetic procedures, odour evaluation and in vitro skin cytotoxicity assays. | 2006 Dec |
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Validation of a HPLC method for simultaneous determination of five sunscreens in lotion preparation. | 2006 Jun |
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Design of a photostabilizer having built-in antioxidant functionality and its utility in obtaining broad-spectrum sunscreen formulations. | 2006 May-Jun |
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Study of the efficacy of 18 sun filters authorized in European Union tested in vitro. | 2007 Jun |
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Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism. | 2008 Apr |
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Photoprotective activity of propolis. | 2008 Feb 15 |
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Quercetin and rutin as potential sunscreen agents: determination of efficacy by an in vitro method. | 2008 Jun |
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Underarm antiperspirants/deodorants and breast cancer. | 2009 |
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Sensitive determination of salicylate and benzophenone type UV filters in water samples using solid-phase microextraction, derivatization and gas chromatography tandem mass spectrometry. | 2009 Apr 6 |
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Determination of selected UV filters in indoor dust by matrix solid-phase dispersion and gas chromatography-tandem mass spectrometry. | 2009 Jul 31 |
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Non-porous membrane-assisted liquid-liquid extraction of UV filter compounds from water samples. | 2009 Jun 12 |
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A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen. | 2010 Mar |
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On-line renewable solid-phase extraction hyphenated to liquid chromatography for the determination of UV filters using bead injection and multisyringe-lab-on-valve approach. | 2010 May 28 |
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Simultaneous determination of the UV-filters benzyl salicylate, phenyl salicylate, octyl salicylate, homosalate, 3-(4-methylbenzylidene) camphor and 3-benzylidene camphor in human placental tissue by LC-MS/MS. Assessment of their in vitro endocrine activity. | 2013 Oct 1 |
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FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1. | 2013 Sep 5 |
Patents
Sample Use Guides
In Vivo Use Guide
Curator's Comment: 30 min after application the remaining product was removed from the skin with two dry cotton swabs and the skin was tape-stripped 16 times with D-Squames. The total amount of UV filters penetrating into the stratum corneum (strips 2–16) from the emulsion gel formulation was 25.7+/-6.4 ug/cm2 (23.2 % applied dose). The total amount of UV filters penetrating from the petroleum formulation was 8.3+/-3.6 ug/cm2 (9.0 % applied dose).
2 mg/cm2 Homosalate was applied to area (2x2 cm) on the volar side of the forearm.
Route of Administration:
Other
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/12566826
Human full-thickness skin was mounted in a conventional static Franz diffusion cells with a receptor volume of 12.4 ml. The UV filters were readily soluble in the receptor fluid. Epidermis and dermis separated by the hot plate method
(60°C for 2 min) and punch biopsies (8 mm) from the tissue samples were taken. Homosalate did not permeate through the skin after 6 h application.
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CFR |
21 CFR 352.10
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CFR |
21 CFR 352.20
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EPA PESTICIDE CODE |
76603
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NCI_THESAURUS |
C851
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C060446
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C83760
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204-260-8
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1311408
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DB11064
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HOMOSALATE
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KK-99
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8362
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100000083986
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118-56-9
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m6047
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3279
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V06SV4M95S
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ACTIVE MOIETY