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Details

Stereochemistry MIXED
Molecular Formula C16H22O3
Molecular Weight 262.3441
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HOMOSALATE

SMILES

CC1CC(CC(C)(C)C1)OC(=O)C2=C(O)C=CC=C2

InChI

InChIKey=WSSJONWNBBTCMG-UHFFFAOYSA-N
InChI=1S/C16H22O3/c1-11-8-12(10-16(2,3)9-11)19-15(18)13-6-4-5-7-14(13)17/h4-7,11-12,17H,8-10H2,1-3H3

HIDE SMILES / InChI

Description

Homosalate is used as a broad-band UV filter in concentrations of up to 10% in the EU or 15% depending upon where the product is used (e.g. in the USA) in sunscreen products alone or in combination with other UV absorbers to protect the skin against harmful effects of the UV radiation.

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
2 mg/cm2 Homosalate was applied to area (2x2 cm) on the volar side of the forearm.
Route of Administration: Other
In Vitro Use Guide
Human full-thickness skin was mounted in a conventional static Franz diffusion cells with a receptor volume of 12.4 ml. The UV filters were readily soluble in the receptor fluid. Epidermis and dermis separated by the hot plate method (60°C for 2 min) and punch biopsies (8 mm) from the tissue samples were taken. Homosalate did not permeate through the skin after 6 h application.