HOMOSALATE

Details

Stereochemistry	MIXED
Molecular Formula	C16H22O3
Molecular Weight	262.3441
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1CC(CC(C)(C)C1)OC(=O)C2=CC=CC=C2O

InChI

InChIKey=WSSJONWNBBTCMG-UHFFFAOYSA-N

InChI=1S/C16H22O3/c1-11-8-12(10-16(2,3)9-11)19-15(18)13-6-4-5-7-14(13)17/h4-7,11-12,17H,8-10H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C16H22O3
Molecular Weight	262.3441
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://ec.europa.eu/health/ph_risk/committees/04_sccp/docs/sccp_o_097.pdf
Curator's Comment: http://www.fda.gov/downloads/ForConsumers/ConsumerUpdates/UCM258718.pdf

Homosalate is used as a broad-band UV filter in concentrations of up to 10% in the EU or 15% depending upon where the product is used (e.g. in the USA) in sunscreen products alone or in combination with other UV absorbers to protect the skin against harmful effects of the UV radiation.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Skin sun damage 1 Sources: https://clinicaltrials.gov/ct2/show/NCT01001975	Preventing		Phase III 665	Unknown Approved Use Unknown

C_max

Value	Dose	Analyte	Population
7.6 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² single, topical dose: 2 mg/cm² route of administration: Topical experiment type: SINGLE co-administered:	HOMOSALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
23.1 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² 4 times / day multiple, topical dose: 2 mg/cm² route of administration: Topical experiment type: MULTIPLE co-administered:	HOMOSALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4.6 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² single, topical dose: 2 mg/cm² route of administration: Topical experiment type: SINGLE co-administered:	HOMOSALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
17.9 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² 4 times / day multiple, topical dose: 2 mg/cm² route of administration: Topical experiment type: MULTIPLE co-administered:	HOMOSALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
3.8 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² single, topical dose: 2 mg/cm² route of administration: Topical experiment type: SINGLE co-administered:	HOMOSALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
14.3 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² 4 times / day multiple, topical dose: 2 mg/cm² route of administration: Topical experiment type: MULTIPLE co-administered:	HOMOSALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Analyte	Population
104 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² single, topical dose: 2 mg/cm² route of administration: Topical experiment type: SINGLE co-administered:	HOMOSALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
350.8 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² 4 times / day multiple, topical dose: 2 mg/cm² route of administration: Topical experiment type: MULTIPLE co-administered:	HOMOSALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
62.3 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² single, topical dose: 2 mg/cm² route of administration: Topical experiment type: SINGLE co-administered:	HOMOSALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
267.4 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² 4 times / day multiple, topical dose: 2 mg/cm² route of administration: Topical experiment type: MULTIPLE co-administered:	HOMOSALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
47.6 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² single, topical dose: 2 mg/cm² route of administration: Topical experiment type: SINGLE co-administered:	HOMOSALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
199 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² 4 times / day multiple, topical dose: 2 mg/cm² route of administration: Topical experiment type: MULTIPLE co-administered:	HOMOSALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Analyte	Population
67.9 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² single, topical dose: 2 mg/cm² route of administration: Topical experiment type: SINGLE co-administered:	HOMOSALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
78.4 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² single, topical dose: 2 mg/cm² route of administration: Topical experiment type: SINGLE co-administered:	HOMOSALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
46.9 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² single, topical dose: 2 mg/cm² route of administration: Topical experiment type: SINGLE co-administered:	HOMOSALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

Doses

Dose	Population	Adverse events
3 % 1 times / 2 hours multiple, topical Recommended Dose: 3 %, 1 times / 2 hours Route: topical Route: multiple Dose: 3 %, 1 times / 2 hours Sources: https://www.drugs.com/pro/sun-defense-cream.html	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: unknown Food Status: UNKNOWN Sources: https://www.drugs.com/pro/sun-defense-cream.html	Sources: https://www.drugs.com/pro/sun-defense-cream.html
20 g/m2 4 times / day multiple, topical Studied dose Dose: 20 g/m2, 4 times / day Route: topical Route: multiple Dose: 20 g/m2, 4 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/31961417/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/31961417/	Sources: https://pubmed.ncbi.nlm.nih.gov/31961417/

PubMed

Title	Date	PubMed
Simultaneous determination of the UV-filters benzyl salicylate, phenyl salicylate, octyl salicylate, homosalate, 3-(4-methylbenzylidene) camphor and 3-benzylidene camphor in human placental tissue by LC-MS/MS. Assessment of their in vitro endocrine activity.	2013-10-01	24004914
FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1.	2013-09-05	23769903
On-line renewable solid-phase extraction hyphenated to liquid chromatography for the determination of UV filters using bead injection and multisyringe-lab-on-valve approach.	2010-05-28	20399441
A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen.	2010-03	20374604
Determination of selected UV filters in indoor dust by matrix solid-phase dispersion and gas chromatography-tandem mass spectrometry.	2009-07-31	19539293
Non-porous membrane-assisted liquid-liquid extraction of UV filter compounds from water samples.	2009-06-12	19419722
Sensitive determination of salicylate and benzophenone type UV filters in water samples using solid-phase microextraction, derivatization and gas chromatography tandem mass spectrometry.	2009-04-06	19298877
Underarm antiperspirants/deodorants and breast cancer.	2009	20030880
Quercetin and rutin as potential sunscreen agents: determination of efficacy by an in vitro method.	2008-06	18512988
Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism.	2008-04	18324785
Photoprotective activity of propolis.	2008-02-15	18266158
Study of the efficacy of 18 sun filters authorized in European Union tested in vitro.	2007-06	17663193
3,3,5-Trimethylcyclohexanols and derived esters: green synthetic procedures, odour evaluation and in vitro skin cytotoxicity assays.	2006-12	18489288
Validation of a HPLC method for simultaneous determination of five sunscreens in lotion preparation.	2006-06	18489278
Design of a photostabilizer having built-in antioxidant functionality and its utility in obtaining broad-spectrum sunscreen formulations.	2006-02-24	16492073
Influence of anatomical site and topical formulation on skin penetration of sunscreens.	2005-09	18360561
Spectroscopic and photochemical properties of the lichen compound lobaric acid.	2005-08-19	16107188
Estrogenic activity of cosmetic components in reporter cell lines: parabens, UV screens, and musks.	2005-02-27	15799449
Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays.	2005-02	15537743
Determination of sixteen UV filters in suncare formulations by high-performance liquid chromatography.	2004-09-17	15499924
Liquid chromatographic assay for common sunscreen agents: application to in vivo assessment of skin penetration and systemic absorption in human volunteers.	2004-04-25	15063329
Active ingredients in sunscreens act as topical penetration enhancers for the herbicide 2,4-dichlorophenoxyacetic acid.	2004-03-15	15020197
Filipina American women's breast cancer knowledge, attitudes, and screening behaviors.	2003-08-15	12921541
UV filters with antagonistic action at androgen receptors in the MDA-kb2 cell transcriptional-activation assay.	2003-07	12730620
Skin penetration and sun protection factor of five UV filters: effect of the vehicle.	2002-04-18	12566826
Comments on "In vitro and in vivo estrogenicity of UV screens".	2001-08	11564627
Determination of the UV filters worldwide authorised in sunscreens by high-performance liquid chromatography. Use of cyclodextrins as mobile phase modifier.	2001-07-06	11471804
Determination of UV-filters in sunscreens by HPLC.	2001-04	11371063
In vitro and in vivo estrogenicity of UV screens.	2001-03	11333184
Korean women: breast cancer knowledge, attitudes and behaviors.	2001	11553321

Patents

Sample Use Guides

In Vivo Use Guide

2 mg/cm2 Homosalate was applied to area (2x2 cm) on the volar side of the forearm.

Route of Administration: Other

In Vitro Use Guide

Human full-thickness skin was mounted in a conventional static Franz diffusion cells with a receptor volume of 12.4 ml. The UV filters were readily soluble in the receptor fluid. Epidermis and dermis separated by the hot plate method (60°C for 2 min) and punch biopsies (8 mm) from the tissue samples were taken. Homosalate did not permeate through the skin after 6 h application.

Substance Class	Chemical Created by `admin` on `Wed Apr 02 07:44:53 GMT 2025` Edited by `admin` on `Wed Apr 02 07:44:53 GMT 2025`
Record UNII	V06SV4M95S
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

EUSOLEX

Preferred Name

English

HOMOSALATE

Official Name

English

HOMOSALATE [USP MONOGRAPH]

Common Name

English

HOMOMENTHYL SALICYLATE

Common Name

English

3,3,5-Trimethylcyclohexyl salicylate

Systematic Name

English

HOMOSALATE [MART.]

Common Name

English

Homosalate [WHO-DD]

Common Name

English

HOMOSALATE [MI]

Common Name

English

2-HYDROXYBENZOIC ACID 3,3,5-TRIMETHYLCYCLOHEXYL ESTER

Systematic Name

English

NSC-164918

Code

English

homosalate [INN]

Common Name

English

HOMOSALATE [USP-RS]

Common Name

English

HOMOSALATE [USAN]

Common Name

English

BENZOIC ACID, 2-HYDROXY-, 3,3,5-TRIMETHYLCYCLOHEXYL ESTER

Common Name

English

HOMOSALATE [USP IMPURITY]

Common Name

English

SALICYLIC ACID 3,3,5-TRIMETHYLCYCLOHEXYL ESTER

Systematic Name

English

Classification Tree Code System Code

CFR

21 CFR 352.10