HOMOSALATE

Details

Stereochemistry	MIXED
Molecular Formula	C16H22O3
Molecular Weight	262.3441
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1CC(CC(C)(C)C1)OC(=O)C2=C(O)C=CC=C2

InChI

InChIKey=WSSJONWNBBTCMG-UHFFFAOYSA-N

InChI=1S/C16H22O3/c1-11-8-12(10-16(2,3)9-11)19-15(18)13-6-4-5-7-14(13)17/h4-7,11-12,17H,8-10H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C16H22O3
Molecular Weight	262.3441
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://ec.europa.eu/health/ph_risk/committees/04_sccp/docs/sccp_o_097.pdf
Curator's Comment: http://www.fda.gov/downloads/ForConsumers/ConsumerUpdates/UCM258718.pdf

Homosalate is used as a broad-band UV filter in concentrations of up to 10% in the EU or 15% depending upon where the product is used (e.g. in the USA) in sunscreen products alone or in combination with other UV absorbers to protect the skin against harmful effects of the UV radiation.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Skin sun damage 1 Sources: https://clinicaltrials.gov/ct2/show/NCT01001975	Preventing		Phase III 656	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Korean women: breast cancer knowledge, attitudes and behaviors.	2001	11553321
In vitro and in vivo estrogenicity of UV screens.	2001 Mar	11333184
Spectroscopic and photochemical properties of the lichen compound lobaric acid.	2005 Nov-Dec	16107188
Influence of anatomical site and topical formulation on skin penetration of sunscreens.	2005 Sep	18360561
3,3,5-Trimethylcyclohexanols and derived esters: green synthetic procedures, odour evaluation and in vitro skin cytotoxicity assays.	2006 Dec	18489288
Validation of a HPLC method for simultaneous determination of five sunscreens in lotion preparation.	2006 Jun	18489278
Design of a photostabilizer having built-in antioxidant functionality and its utility in obtaining broad-spectrum sunscreen formulations.	2006 May-Jun	16492073
Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism.	2008 Apr	18324785
Photoprotective activity of propolis.	2008 Feb 15	18266158
Quercetin and rutin as potential sunscreen agents: determination of efficacy by an in vitro method.	2008 Jun	18512988
Underarm antiperspirants/deodorants and breast cancer.	2009	20030880
Determination of selected UV filters in indoor dust by matrix solid-phase dispersion and gas chromatography-tandem mass spectrometry.	2009 Jul 31	19539293
Non-porous membrane-assisted liquid-liquid extraction of UV filter compounds from water samples.	2009 Jun 12	19419722
A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen.	2010 Mar	20374604
On-line renewable solid-phase extraction hyphenated to liquid chromatography for the determination of UV filters using bead injection and multisyringe-lab-on-valve approach.	2010 May 28	20399441
Simultaneous determination of the UV-filters benzyl salicylate, phenyl salicylate, octyl salicylate, homosalate, 3-(4-methylbenzylidene) camphor and 3-benzylidene camphor in human placental tissue by LC-MS/MS. Assessment of their in vitro endocrine activity.	2013 Oct 1	24004914
FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1.	2013 Sep 5	23769903

Patents

Sample Use Guides

In Vivo Use Guide

2 mg/cm2 Homosalate was applied to area (2x2 cm) on the volar side of the forearm.

Route of Administration: Other

In Vitro Use Guide

Human full-thickness skin was mounted in a conventional static Franz diffusion cells with a receptor volume of 12.4 ml. The UV filters were readily soluble in the receptor fluid. Epidermis and dermis separated by the hot plate method (60°C for 2 min) and punch biopsies (8 mm) from the tissue samples were taken. Homosalate did not permeate through the skin after 6 h application.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:21:29 GMT 2023` Edited by `admin` on `Sat Dec 16 16:21:29 GMT 2023`
Record UNII	V06SV4M95S
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HOMOSALATE

Official Name

English

HOMOSALATE [USP MONOGRAPH]

Common Name

English

HOMOMENTHYL SALICYLATE

Common Name

English

HOMOSALATE [INCI]

Common Name

English

3,3,5-Trimethylcyclohexyl salicylate

Systematic Name

English

HOMOSALATE [MART.]

Common Name

English

Homosalate [WHO-DD]

Common Name

English

HOMOSALATE [MI]

Common Name

English

2-HYDROXYBENZOIC ACID 3,3,5-TRIMETHYLCYCLOHEXYL ESTER

Systematic Name

English

NSC-164918

Code

English

EUSOLEX

Brand Name

English

homosalate [INN]

Common Name

English

HOMOSALATE [USP-RS]

Common Name

English

HOMOSALATE [USAN]

Common Name

English

BENZOIC ACID, 2-HYDROXY-, 3,3,5-TRIMETHYLCYCLOHEXYL ESTER

Common Name

English

HOMOSALATE [USP IMPURITY]

Common Name

English

SALICYLIC ACID 3,3,5-TRIMETHYLCYCLOHEXYL ESTER

Systematic Name

English

Classification Tree Code System Code

CFR

21 CFR 352.10