U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 11 - 20 of 41 results

Status:
US Previously Marketed
Source:
Maxatil by SC Johnson
(1970)
Source URL:
First approved in 1970
Source:
Maxatil by SC Johnson
Source URL:

Class (Stereo):
CHEMICAL (UNKNOWN)

Conditions:

Menthyl anthranilate (meradimate) is an active ingredient used in sunscreen drug products for over-the-counter (OTC) human use. Maximum FDA-approved Concentration - 5%. Range of Protection - UVA2.
Status:
US Previously Marketed
Source:
Solhar by Person-Covey
(1966)
Source URL:
First approved in 1966
Source:
Solhar by Person-Covey
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Dioxybenzone (benzophenone-8) is an organic compound used in sunscreen to block UVB and short-wave UVA rays. It is a derivative of benzophenone. It is insoluble in water, which lends to the ‘waterproof’ claims that sunscreens make. It’s approved for use in the US at a concentration of 3%.
Status:
US Previously Marketed
Source:
Solhar by Person-Covey
(1966)
Source URL:
First approved in 1966
Source:
Solhar by Person-Covey
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Oxybenzone is one of the more popular molecules used by chemists during the manufacturing of cosmetics and is included in sunscreen for UV protection. The chemical is often used to stabilize and strengthen the color and scent of skin care products, but its widest use is in the form of sun block. Unfortunately, the debate about the safety of oxybenzone is still ongoing. One of the biggest concerns in the medical community about the widespread use of the molecule comes from the fact that it’s easily absorbed into the body. This absorption raises concerns that oxybenzone may accumulate in the body, eventually leading to potentially toxic levels of the chemical, which can affect the endocrine system.
Status:
US Previously Marketed
Source:
Uval by Stuart
(1964)
Source URL:
First approved in 1964
Source:
Uval by Stuart
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Sulisobenzone (benzophenone-4) is an ingredient for use in sunscreens which protects the skin from damage by UVB and short-wave UVA ultraviolet light. The Food and Drug Administration (FDA) has approved the use of Benzophenone-4 as safe and effective, over-the-counter (OTC) sunscreen ingredient. Sulisobenzone is a subject to the FDA 2011 sunscreen final rule: it can be marketed without approved drug applications (without NDAs or ANDAs), must bear the statement of identity “sunscreen" and contain the information about SPF test. However it is said to be widely used in cosmetic products not labeled as sunscreens such as creams, moisturizers, shampoos and other hair care products, nail polish, lipsticks and lip balms. Sulisobenzone may cause contact dermatitis when used in cosmetics and toiletries. Benzophenone 4 is tested as 10%. It was reported that 10% sulisobenzone enhance skin penetration of the moderately lipophilic herbicide 2,4-D.
Status:
US Previously Marketed
Source:
Photoplex by Herbert
(1988)
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)


Padimate O is an organic compound related to the water-soluble compound PABA (4-aminobenzoic acid) that is used as an ingredient in some sunscreens. this chemical releases free radicals, damages DNA, has estrogenic activity, and causes allergic reactions in some people. Maximum FDA-approved concentration - 8%. Range of protection - UVB.
Status:
US Previously Marketed
Source:
Sundare Clear by Texas Pharmacal
(1961)
Source URL:
First approved in 1961
Source:
Sundare Clear by Texas Pharmacal
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Cinoxate, a cinnamate, is a potent ultraviolet absorber at 289 nm. It is approved by FDA as the active ingredient in sunscreen compositions for over-the-counter (OTC) use at concentrations up to 3% and a minimum SPF value of not less than 2 in the finished product but is rarely used It can cause photoallergic contact dermatitis.
Status:
US Previously Marketed
Source:
Sunstick by Parke Davis
(1952)
Source URL:
First approved in 1952
Source:
Sunstick by Parke Davis
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Digalloyl trioleate used in personal care products as an UV absorbing agent, possessed anti-oxidizing, dispersing abilities. It;s no longer available as it apparently exhibits a poor UV absorbtion profile. Researchers from the Institute of Pharmacology and Toxicology at the University of Zurich, Switzerland have found that five out of six commonly used chemical sunscreens dose the body with synthetic estrogens. And harmful chemical sunscreens include digalloyl trioleate is banned by the European Union.
Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(29) sunscreen glyceryl aminobenzoate (lisadimate, glyceryl PABA)
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Conditions:

Lisadimate (glyceryl PABA), a substituted aminobenzoate, is a sunscreen with actions similar to those of aminobenzoic acid. It is effective against UVB light. Glyceryl PABA (Escalol 106), present in many popular sunscreens, is a common sensitizer which invariably cross-reacts with benzocaine; it is present in over 400 over-the-counter products. Glyceryl PABA does not appear to cross-react with the sunscreening agents amyl (Escalol 506) and octyl (Escalol 507) dimethyl PABA. Glyceryl PABA, may, on occasion, cross-react with para-aminobenzoic acid (PABA), paraphenylenediamine, aniline, and sulfa drugs. Ironically, the sunscreening agent glyceryl PABA may, itself, act as a photosensitizing agent.
Status:
US Previously Marketed
Source:
64 FR 27682 sunscreen 2-ethylhexyl-4-phenylbenzophenone-2-carboxylic acid
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

2-Ethylhexyl-4-phenyl-benzophenone carbonate (Eusolex 3573) is a component of sunscreen and possesses of ultraviolet A (UV-A) absorbing properties.
Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(29) sunscreen ethyl 4-[bis(hydroxypropyl)] aminobenzoate (roxadimate)
Source URL:

Class (Stereo):
CHEMICAL (MIXED)


Roxadimate was used for cracked or chapped lips. Used to reduce skin mutation and DNA damage

Showing 11 - 20 of 41 results