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Details

Stereochemistry ACHIRAL
Molecular Formula C14H12O6S
Molecular Weight 308.306
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SULISOBENZONE

SMILES

COC1=CC(O)=C(C=C1S(O)(=O)=O)C(=O)C2=CC=CC=C2

InChI

InChIKey=CXVGEDCSTKKODG-UHFFFAOYSA-N
InChI=1S/C14H12O6S/c1-20-12-8-11(15)10(7-13(12)21(17,18)19)14(16)9-5-3-2-4-6-9/h2-8,15H,1H3,(H,17,18,19)

HIDE SMILES / InChI

Molecular Formula C14H12O6S
Molecular Weight 308.306
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Sulisobenzone (benzophenone-4) is an ingredient for use in sunscreens which protects the skin from damage by UVB and short-wave UVA ultraviolet light. The Food and Drug Administration (FDA) has approved the use of Benzophenone-4 as safe and effective, over-the-counter (OTC) sunscreen ingredient. Sulisobenzone is a subject to the FDA 2011 sunscreen final rule: it can be marketed without approved drug applications (without NDAs or ANDAs), must bear the statement of identity “sunscreen" and contain the information about SPF test. However it is said to be widely used in cosmetic products not labeled as sunscreens such as creams, moisturizers, shampoos and other hair care products, nail polish, lipsticks and lip balms. Sulisobenzone may cause contact dermatitis when used in cosmetics and toiletries. Benzophenone 4 is tested as 10%. It was reported that 10% sulisobenzone enhance skin penetration of the moderately lipophilic herbicide 2,4-D.

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
BENEFIT TRIPLE PERFORMING FACIAL BROAD SPECTRUM SPF15

Cmax

ValueDoseCo-administeredAnalytePopulation
1.8 μg/g
0.1 mg single, topical
SULISOBENZONE unknown
Rattus norvegicus

AUC

ValueDoseCo-administeredAnalytePopulation
23.2 μg × h/mL
0.1 mg single, topical
SULISOBENZONE unknown
Rattus norvegicus

T1/2

ValueDoseCo-administeredAnalytePopulation
9 h
0.1 mg single, topical
SULISOBENZONE unknown
Rattus norvegicus

PubMed

Sample Use Guides

In Vivo Use Guide
Apply sunscreen that contains Avobenzone 3.00% Octinoxate 7.49% Octocrylene 2.00% Sulisobenzone 1.50% liberally 15 minutes before sun exposure. Reapply at least every 2 hours. Children under 6 months of age: ask a doctor.
Route of Administration: Topical
In Vitro Use Guide
After 1 hr incubation with five test concentrations of each chemical compound, epidermis was then exposed or not to UVA at a non-cytotoxic dose (50 J/sq cm). 18 hr after UVA exposure, cellular damage was evaluated measuring cytotoxicity by MTT conversion test.
Substance Class Chemical
Record UNII
1W6L629B4K
Record Status Validated (UNII)
Record Version