Details
Stereochemistry | ACHIRAL |
Molecular Formula | C14H12O4 |
Molecular Weight | 244.2427 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(O)=C(C=C1)C(=O)C2=C(O)C=CC=C2
InChI
InChIKey=MEZZCSHVIGVWFI-UHFFFAOYSA-N
InChI=1S/C14H12O4/c1-18-9-6-7-11(13(16)8-9)14(17)10-4-2-3-5-12(10)15/h2-8,15-16H,1H3
Molecular Formula | C14H12O4 |
Molecular Weight | 244.2427 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionCurator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/5569329 and http://www.sun-protection-and-products-guide.com/sunscreen-ingredients.html
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/5569329 and http://www.sun-protection-and-products-guide.com/sunscreen-ingredients.html
Dioxybenzone (benzophenone-8) is an organic compound used in sunscreen to block UVB and short-wave UVA rays. It is a derivative of benzophenone. It is insoluble in water, which lends to the ‘waterproof’ claims that sunscreens make. It’s approved for use in the US at a concentration of 3%.
Approval Year
PubMed
Title | Date | PubMed |
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Structure-activity relationships for a large diverse set of natural, synthetic, and environmental estrogens. | 2001 Mar |
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[Estrogenic activity of ultraviolet absorbers and the related compounds]. | 2005 Aug |
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Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 Nov |
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Sensitive determination of salicylate and benzophenone type UV filters in water samples using solid-phase microextraction, derivatization and gas chromatography tandem mass spectrometry. | 2009 Apr 6 |
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Determination of hydroxylated benzophenone UV filters in sea water samples by dispersive liquid-liquid microextraction followed by gas chromatography-mass spectrometry. | 2010 Jul 16 |
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Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities. | 2012 Nov 19 |
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Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. | 2015 Feb |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: http://www.skincancer.org/prevention/sun-protection/sunscreen/the-skin-cancer-foundations-guide-to-sunscreens
Curator's Comment: Maximum FDA-approved concentration of Dioxybenzone in sunscreen 3%
The dose used in FDA sunscreen testing is 2 mg/cm2 of exposed skin. Sunscreen should be applied one-half hour before going outside, giving the skin time to absorb it. It should be reapplied at least every two hours outdoors, and immediately after swimming or heavy sweating. At least one ounce (two tablespoons) is needed to cover the entire body surface.
Route of Administration:
Topical
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/26016852
To clarify the photoreactivity of Dioxybenzone, the ROS assay was undertaken with the use of Dioxybenzone at 200 uM
Substance Class |
Chemical
Created
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admin
on
Edited
Sat Dec 16 16:43:42 GMT 2023
by
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on
Sat Dec 16 16:43:42 GMT 2023
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Record UNII |
B762XZ551X
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Record Status |
Validated (UNII)
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NCI_THESAURUS |
C851
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CFR |
21 CFR 352.10
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CFR |
21 CFR 352.20
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100000082876
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1214004
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B762XZ551X
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56769
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DB11221
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C74399
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23350
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SUB07206MIG
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m4602
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205-026-8
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3159
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8569
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C004839
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DIOXYBENZONE
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B762XZ551X
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DTXSID3022403
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2097
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