CINOXATE

US Previously Marketed

First approved in 1961

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H18O4
Molecular Weight	250.2903
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOCCOC(=O)\C=C\C1=CC=C(OC)C=C1

InChI

InChIKey=CMDKPGRTAQVGFQ-RMKNXTFCSA-N

InChI=1S/C14H18O4/c1-3-17-10-11-18-14(15)9-6-12-4-7-13(16-2)8-5-12/h4-9H,3,10-11H2,1-2H3/b9-6+

HIDE SMILES / InChI

Molecular Formula	C14H18O4
Molecular Weight	250.2903
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/cfrsearch.cfm?fr=352.10
Curator's Comment: Description was created using several sources including: http://www.particlesciences.com/docs/A_review_of_sunscreen_safety_and_efficacy.pdf; http://www.ncbi.nlm.nih.gov/pubmed/?term=23112351 http://www.ncbi.nlm.nih.gov/pubmed/2499777; http://www.ncbi.nlm.nih.gov/pubmed/3621935;

Cinoxate, a cinnamate, is a potent ultraviolet absorber at 289 nm. It is approved by FDA as the active ingredient in sunscreen compositions for over-the-counter (OTC) use at concentrations up to 3% and a minimum SPF value of not less than 2 in the finished product but is rarely used It can cause photoallergic contact dermatitis.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

Sourcing

Vendor/Aggregator	ID	URL
Alfa Chemistry	104-28-9	https://www.alfa-chemistry.com/cinoxate-cas-104-28-9-item-289475.htm
Alfa Chemistry	AP104289	https://reagents.alfa-chemistry.com/product/cinoxate-cas-104-28-9-997.html
Ambinter	Amb22729187	http://www.ambinter.com/reference/22729187
Aurora Fine Chemicals LLC	A17.908.018	http://online.aurorafinechemicals.com/info?ID=A17.908.018
ChemMol	49400350	http://www.chemmol.com/chemmol/49400350.html
Chemspace	CSSB00020675266	https://chem-space.com/CSSB00020675266
iChemical	EBD52144	http://www.ichemical.com/chemicals/cas-104-28-9
MuseChem	M047301	https://www.musechem.com/product/M047301.html
Parchem	37692	https://www.parchem.com/chemical-supplier-distributor/Cinoxate-037692.aspx
Sigma-Aldrich	67790_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/67790?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Smolecule	S624243	https://www.smolecule.com/products/s624243
THE BioTek	bt-463327	https://www.thebiotek.com/product/others/bt-463327
Yuhao Chemical	RT12271	http://www.chemyuhao.com/104-28-9.html

PubMed

Title	Date	PubMed
[Simultaneous determination of 9 ultraviolet absorbers in cosmetics by high-performance liquid chromatography].	2007	18220048
Enhancing effects of cinoxate and methyl sinapate on the frequencies of sister-chromatid exchanges and chromosome aberrations in cultured mammalian cells.	1989-06	2499777
Photoallergic contact dermatitis to 2-ethoxyethyl-p-methoxycinnamate.	1987-05	3621935
A study of the photochemical properties of some cinnamate sunscreens by steady state and laser flash photolysis.	1982-10	7146110
Acute photosensitivity from the sunscreen 2-ethoxyethyl-p-methoxycinnamate.	1982-05	7094573
Influence of sunscreening agents on color stability of tablets coated with certified dyes III: FD&C Yellow No. 6.	1977-01	833722

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:30:40 GMT 2025` Edited by `admin` on `Wed Apr 02 09:30:40 GMT 2025`
Record UNII	5437O7N5BH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CINOXATE

Official Name

English

CINOXATE [HSDB]

Preferred Name

English

cinoxate [INN]

Common Name

English

Cinoxate [WHO-DD]

Common Name

English

2-PROPENOIC ACID, 3-(4-METHOXYPHENYL)-, 2-ETHOXYETHYL ESTER

Common Name

English

CINOXATE [MI]

Common Name

English

CINOXATE [VANDF]

Common Name

English

CINOXATE [USAN]

Common Name

English

CINOXATE [MART.]

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

76604