Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H12O4 |
| Molecular Weight | 244.2427 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(O)=C(C=C1)C(=O)C2=C(O)C=CC=C2
InChI
InChIKey=MEZZCSHVIGVWFI-UHFFFAOYSA-N
InChI=1S/C14H12O4/c1-18-9-6-7-11(13(16)8-9)14(17)10-4-2-3-5-12(10)15/h2-8,15-16H,1H3
DescriptionCurator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/5569329 and http://www.sun-protection-and-products-guide.com/sunscreen-ingredients.html
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/5569329 and http://www.sun-protection-and-products-guide.com/sunscreen-ingredients.html
Dioxybenzone (benzophenone-8) is an organic compound used in sunscreen to block UVB and short-wave UVA rays. It is a derivative of benzophenone. It is insoluble in water, which lends to the ‘waterproof’ claims that sunscreens make. It’s approved for use in the US at a concentration of 3%.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Estrogenic activity of ultraviolet absorbers and the related compounds]. | 2005 Aug |
|
| Estrogenic activities of chemicals related to food contact plastics and rubbers tested by the yeast two-hybrid assay. | 2006 Apr |
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| Activity related to the carcinogenicity of plastic additives in the benzophenone group. | 2006 Jun 1 |
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| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 Nov |
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| Simultaneous determination of benzophenone-type UV filters in water and soil by gas chromatography-mass spectrometry. | 2006 Oct 27 |
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| Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities. | 2012 Nov 19 |
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| Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. | 2015 Feb |
Patents
Sample Use Guides
In Vivo Use Guide
Curator's Comment: Maximum FDA-approved concentration of Dioxybenzone in sunscreen 3%
The dose used in FDA sunscreen testing is 2 mg/cm2 of exposed skin. Sunscreen should be applied one-half hour before going outside, giving the skin time to absorb it. It should be reapplied at least every two hours outdoors, and immediately after swimming or heavy sweating. At least one ounce (two tablespoons) is needed to cover the entire body surface.
Route of Administration:
Topical
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C851
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CFR |
21 CFR 352.10
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CFR |
21 CFR 352.20
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100000082876
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1214004
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B762XZ551X
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56769
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DB11221
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C74399
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131-53-3
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23350
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SUB07206MIG
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m4602
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205-026-8
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3159
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CHEMBL1326877
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8569
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C004839
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DIOXYBENZONE
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B762XZ551X
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DTXSID3022403
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2097
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ACTIVE MOIETY
