U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula O.Zn
Molecular Weight 81.408
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ZINC OXIDE

SMILES

[O--].[Zn++]

InChI

InChIKey=RNWHGQJWIACOKP-UHFFFAOYSA-N
InChI=1S/O.Zn/q-2;+2

HIDE SMILES / InChI

Description

There is no available information related any biological and pharmaceutical application of ammonium tetrachlorozincate.

CNS Activity

Originator

Approval Year

PubMed

PubMed

TitleDatePubMed
In vitro activity of zinc salts against human rhinoviruses.
1987 Apr
A medicated polycarboxylate cement to prevent complications in composite resin therapy.
1990 Jan
Zinc inhibition of renin and the protease from human immunodeficiency virus type 1.
1991 Sep 10
Molecular modeling studies suggest that zinc ions inhibit HIV-1 protease by binding at catalytic aspartates.
1993 Aug
Topical zinc oxide treatment increases endogenous gene expression of insulin-like growth factor-1 in granulation tissue from porcine wounds.
1994 Dec
New applications for the zinc iodide-osmium tetroxide technique.
1994 Feb
Iron chelators as therapeutic agents against Pneumocystis carinii.
1994 May
SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus.
1997 Feb
Enantioselective Cyclopropanation of Allylic Alcohols. The Effect of Zinc Iodide.
1997 May 16
Thujaplicin-copper chelates inhibit replication of human influenza viruses.
1998 Aug
Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study.
1999 May
Inhibition of HIV-1 infection by zinc group metal compounds.
1999 Sep
Combined effects of argon laser irradiation and fluoride treatments in prevention of caries-like lesion formation in enamel: an in vitro study.
1999 Spring
Bioavailability, biodistribution, and toxicity of BioZn-AAS(1): a new zinc source. comparative studies in rats.
2000 Sep
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.
2002 Mar 1
Comparison of the levels of copper, zinc and iron in cervical mucus and in blood serum of women of childbearing age.
2004
Thermotoga maritima-Escherichia coli chimeric topoisomerases. Answers about involvement of the carboxyl-terminal domain in DNA topoisomerase I-mediated catalysis.
2004 Jul 16
Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium.
2004 Jul 16
Inhibition by copper(II) binding of hepatocyte growth factor (HGF) interaction with its receptor Met and blockade of HGF/Met function.
2004 Jul 30
High-throughput computational and experimental techniques in structural genomics.
2004 Oct
Impact of the mother's zinc deficiency on the woman's and newborn's health status.
2005
[Zinc and aluminum concentrations in blood of hemodialysis patients and its impact on the frequency of infections].
2005
Angiotensin II receptor blocker-induces blunted taste sensitivity: comparison of candesartan and valsartan.
2005 Aug
Low dietary zinc decreases erythrocyte carbonic anhydrase activities and impairs cardiorespiratory function in men during exercise.
2005 May
Copper, zinc, and Cu/Zn ratio in carcinoma of the gallbladder.
2005 Sep 1
Effects of zinc supplementation in patients with type 1 diabetes.
2005 Summer
Characterization and inhibition of SARS-coronavirus main protease.
2006
Zinc nutritional status of morbidly obese patients before and after Roux-en-Y gastric bypass: a preliminary report.
2006 Apr
Copper and zinc concentrations in serum of healthy Greek adults.
2006 Apr 15
Elevated cortical zinc in Alzheimer disease.
2006 Jul 11
The effect of Ramadan on maternal nutrition and composition of breast milk.
2006 Jun
Marginal zinc deficiency increased the susceptibility to acute lipopolysaccharide-induced liver injury in rats.
2006 May
Quantum dots trigger immunomodulation of the NFκB pathway in human skin cells.
2011 Jul
Distinct immunomodulatory effects of a panel of nanomaterials in human dermal fibroblasts.
2012 May 5
Inorganic salts in atmospheric particulate matter: Raman spectroscopy as an analytical tool.
2013 Nov
Mechanism of uptake of ZnO nanoparticles and inflammatory responses in macrophages require PI3K mediated MAPKs signaling.
2014 Apr
Additive effect of zinc oxide nanoparticles and isoorientin on apoptosis in human hepatoma cell line.
2014 Mar 3
Immunomodulatory activity of zinc peroxide (ZnO₂) and titanium dioxide (TiO₂) nanoparticles and their effects on DNA and protein integrity.
2014 May 16
Zinc oxide nanoparticles induce apoptosis by enhancement of autophagy via PI3K/Akt/mTOR inhibition.
2014 May 16
ZnO nanoparticles induced adjuvant effect via toll-like receptors and Src signaling in Balb/c mice.
2014 Nov 4
Ultrasonic assisted removal of sunset yellow from aqueous solution by zinc hydroxide nanoparticle loaded activated carbon: Optimized experimental design.
2015
Endoplasmic reticulum stress and oxidative stress are involved in ZnO nanoparticle-induced hepatotoxicity.
2015 Apr 2
Synthesis aspects, structural, spectroscopic, antimicrobial and room temperature ferromagnetism of zinc iodide complex with Schiff based ligand.
2015 Jan 25
Simultaneous sulfate and zinc removal from acid wastewater using an acidophilic and autotrophic biocathode.
2016 Mar 5
Spectroscopic probe to contribution of physicochemical transformations in the toxicity of aged ZnO NPs to Chlorella vulgaris: new insight into the variation of toxicity of ZnO NPs under aging process.
2016 Oct
Effects of zinc fluoride on inhibiting dentin demineralization and collagen degradation in vitro: A comparison of various topical fluoride agents.
2016 Oct 1
Risk Assessment Study of Fluoride Salts: Probability-Impact Matrix of Renal and Hepatic Toxicity Markers.
2016 Sep
Mycobacterial carbonic anhydrase inhibition with phenolic acids and esters: kinetic and computational investigations.
2016 Sep 21
Intense 2.7μm emission in Er3+ doped zinc fluoride glass.
2017 May 15
Patents

Sample Use Guides

In Vivo Use Guide
Rats: The dosage of zinc fluoride tetrahydrate (ZnF2 •4H2O) was adjusted to contain 2.1 mg (low-dose group, LG), 4.3 mg (mid-dose group, MG), and 5.4 mg fluoride per 200 g rat body weight (high-dose group, HG) corresponding to 5, 10, and 12.5 % of LD50 values for NaF.
Route of Administration: Oral; Topical
In Vitro Use Guide
Prepared ground human enamel specimens were immersed in zinc fluoride solutions containing 250 and 750 ppm F- at pH 6 and 4 for 4 min.
Name Type Language
ZINC OXIDE
EP   FCC   HSDB   II   INCI   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
INCI  
Official Name English
ZINC OXIDE COMPONENT OF VUSION
Common Name English
ZINC OXIDE [WHO-DD]
Common Name English
C.I. 77947
Common Name English
ZINC OXIDE [USP-RS]
Common Name English
ZINC WHITE
Common Name English
ZINC (AS ZINC OXIDE) [VANDF]
Common Name English
ZINC OXIDE COMPONENT OF CALAMINE
Common Name English
CALAMINE COMPONENT ZINC OXIDE
Common Name English
CI 77947
INCI  
INCI  
Official Name English
C.I. PIGMENT WHITE 4
Common Name English
ZINCUM OXYDATUM
HPUS  
Common Name English
ZINC OXIDE [MART.]
Common Name English
ZINC OXIDE EMULSION [VANDF]
Common Name English
ZINC OXIDE [WHO-IP]
Common Name English
ZINC PASTE [VANDF]
Common Name English
ZINC OXIDE [HSDB]
Common Name English
ZINC OXIDE [INCI]
Common Name English
ZINC OXIDE [ORANGE BOOK]
Common Name English
ZINC OXIDE [EP]
Common Name English
ZINC OXIDE [FCC]
Common Name English
ZINC OXIDE [II]
Common Name English
ZINCI OXYDUM [WHO-IP LATIN]
Common Name English
ZINC OXIDE [JAN]
Common Name English
ZINC OXIDE [VANDF]
Common Name English
CI 77947 [INCI]
Common Name English
ZINC (AS OXIDE) [VANDF]
Common Name English
VUSION COMPONENT ZINC OXIDE
Common Name English
ZINC OXIDE [USP]
Common Name English
ZINC PASTE
VANDF  
Common Name English
ZINC OXIDE [MI]
Common Name English
ZINCUM OXYDATUM [HPUS]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 178.3297
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
CFR 21 CFR 175.300
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
CFR 21 CFR 175.380
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
CFR 21 CFR 177.1460
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
CFR 21 CFR 177.1900
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
FDA ORPHAN DRUG 142401
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
CFR 21 CFR 310.531
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
CFR 21 CFR 352.20
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
CFR 21 CFR 352.10
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
WHO-VATC QA07XA91
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
Food Contact Sustance Notif, (FCN No.) FCN NO. 193
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
EPA PESTICIDE CODE 88502
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
CFR 21 CFR 347.10
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
NCI_THESAURUS C851
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
CFR 21 CFR 346.18
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
CFR 21 CFR 177.1350
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
CFR 21 CFR 176.170
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
Code System Code Type Description
DRUG BANK
DB09321
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
PRIMARY
MERCK INDEX
M11617
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
PRIMARY Merck Index
PUBCHEM
3007857
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
PRIMARY
WIKIPEDIA
ZINC OXIDE
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
ZINC OXIDE
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
PRIMARY Description: A white or faintly yellowish white, very fine, amorphous powder, free from grittiness; odourless. Solubility: Practically insoluble in water and ethanol (~750 g/l) TS; soluble in hydrochloric acid (~70 g/l) TS. Category: Mild astringent used topically as a protective. Storage: Zinc oxide should be kept in a well-closed container. Additional information: Zinc oxide gradually absorbs carbon dioxide from the air. Definition: Zinc oxide contains not less than 99.0% and not more than 100.5% of ZnO, calculated with reference to the freshly ignited substance.
EVMPD
SUB12623MIG
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
PRIMARY
EPA CompTox
1314-13-2
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
PRIMARY
MESH
D015034
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
PRIMARY
NCI_THESAURUS
C949
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
PRIMARY
HSDB
1314-13-2
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
PRIMARY
RXCUI
11423
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
PRIMARY RxNorm
CAS
1314-13-2
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
PRIMARY
ChEMBL
CHEMBL1201128
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
PRIMARY
ECHA (EC/EINECS)
215-222-5
Created by admin on Tue Oct 22 06:17:59 UTC 2019 , Edited by admin on Tue Oct 22 06:17:59 UTC 2019
PRIMARY