MEXENONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H14O3
Molecular Weight	242.2699
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C(=O)C2=CC=C(C)C=C2)C(O)=C1

InChI

InChIKey=MJVGBKJNTFCUJM-UHFFFAOYSA-N

InChI=1S/C15H14O3/c1-10-3-5-11(6-4-10)15(17)13-8-7-12(18-2)9-14(13)16/h3-9,16H,1-2H3

HIDE SMILES / InChI

Molecular Formula	C15H14O3
Molecular Weight	242.2699
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.dormer.com/Allergens/PDF/P_InfoEn/H-020B.pdf | https://www.dermnetnz.org/topics/allergy-to-benzophenone | https://www.ncbi.nlm.nih.gov/pubmed/1935041 | https://www.drugs.com/international/episol.html | https://www.ncbi.nlm.nih.gov/pubmed/3677658

Mexenone is a benzophenone-derived UV absorbing compound used in sunscreen cosmetics such as creams, lotions, lipsticks and sun oils. It is not uncommon for Mexone and other related benzophenones to cause an allergic reaction when applied to the skin.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Sunburn 84 Sources: http://www.dormer.com/Allergens/PDF/P_InfoEn/H-020B.pdf	Preventing		Approved 8429	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
[Photoaggravated contact allergy and contact photoallergy caused by ketoprofen: 19 cases].	2001 Oct	11907961
Causal agents of photoallergic contact dermatitis diagnosed in the national institute of dermatology of Colombia.	2006 Aug	16869867
Measurement of benzophenones in human urine samples by stir bar sorptive extraction and thermal desorption-gas chromatography-mass spectrometry.	2008	18997384
Simultaneous analysis of benzophenone sunscreen compounds in water sample by stir bar sorptive extraction with in situ derivatization and thermal desorption-gas chromatography-mass spectrometry.	2008 Jul 25	18550077
Miniaturized hollow fiber assisted liquid-phase microextraction and gas chromatography-mass spectrometry for determination of benzophenone and derivates in human urine sample.	2009 Jan 15	19117809

Patents

Sample Use Guides

In Vivo Use Guide

280 patients exhibiting photosensitivity and other patients suspected of sunscreen dermatitis were patch and photo-patch tested with a pre-selected series of relevant contact allergens and photo-allergens, including Mexenone. Fifteen of the 280 patients (5%) had posative allergic reactions; 3 of them were allergic to more than one agent. The most frequent contact allergens were hydroxy methoxy methyl benzophenone (Mexenone), followed by isopropyl dibenzoylmethane (Eusolex 8020/8021), octyl dimethyl para-aminobenzoate (Escalol 507).

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:14:16 GMT 2023` Edited by `admin` on `Fri Dec 15 16:14:16 GMT 2023`
Record UNII	ET1UGF4A0B
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MEXENONE

Official Name

English

NSC-760432

Code

English

Mexenone [WHO-DD]

Common Name

English

BENZOPHENONE-10

Official Name

English

BENZOPHENONE-10 [INCI]

Common Name

English

MEXENONE [MI]

Common Name

English

mexenone [INN]

Common Name

English

2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE

Systematic Name

English

MEXENONE [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C851