MEXENONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H14O3
Molecular Weight	242.2699
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C(=O)C2=CC=C(C)C=C2)C(O)=C1

InChI

InChIKey=MJVGBKJNTFCUJM-UHFFFAOYSA-N

InChI=1S/C15H14O3/c1-10-3-5-11(6-4-10)15(17)13-8-7-12(18-2)9-14(13)16/h3-9,16H,1-2H3

HIDE SMILES / InChI

Molecular Formula	C15H14O3
Molecular Weight	242.2699
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.dormer.com/Allergens/PDF/P_InfoEn/H-020B.pdf | https://www.dermnetnz.org/topics/allergy-to-benzophenone | https://www.ncbi.nlm.nih.gov/pubmed/1935041 | https://www.drugs.com/international/episol.html | https://www.ncbi.nlm.nih.gov/pubmed/3677658

Mexenone is a benzophenone-derived UV absorbing compound used in sunscreen cosmetics such as creams, lotions, lipsticks and sun oils. It is not uncommon for Mexone and other related benzophenones to cause an allergic reaction when applied to the skin.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Sunburn 84 Sources: http://www.dormer.com/Allergens/PDF/P_InfoEn/H-020B.pdf	Preventing		Approved 8583	Unknown Approved Use Unknown

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inhibitor 2252 inducer 1087	inhibitor 2438	inhibitor 2507	substrate 9

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP1A2 2153 CYP2C19 2057	P-gp 2052

Drug as perpetrator

Target	Modality	Activity
CYP3A4 2633	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/71645#section=Biological-Test-Results Page: 3.0	no [IC50 5.0824 uM]
CYP3A4 2633	inducer 1966 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/71645#section=Biological-Test-Results Page: 81.0	no
CYP1A2 2333	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/71645#section=Biological-Test-Results Page: 12.0	yes [IC50 20.2335 uM]
CYP2C9 2497	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/71645#section=Biological-Test-Results Page: 13.0	yes [IC50 22.7024 uM]
CYP2D6 2546	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/71645#section=Biological-Test-Results Page: 17.0	yes [IC50 40.3712 uM]
CYP2C19 2141	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/71645#section=Biological-Test-Results Page: 2.0	yes [IC50 5.0824 uM]

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
P-gp 2052	substrate 4014 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/71645#section=Biological-Test-Results Page: 79 \| 81	no

Tox targets

Target	Modality	Activity	Metabolite	Clinical evidence
hERG 2263	substrate 9 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/71645#section=Biological-Test-Results Page: 14.0

PubMed

Title	Date	PubMed
Miniaturized hollow fiber assisted liquid-phase microextraction and gas chromatography-mass spectrometry for determination of benzophenone and derivates in human urine sample.	2009-01-15	19117809
Simultaneous analysis of benzophenone sunscreen compounds in water sample by stir bar sorptive extraction with in situ derivatization and thermal desorption-gas chromatography-mass spectrometry.	2008-07-25	18550077
Measurement of benzophenones in human urine samples by stir bar sorptive extraction and thermal desorption-gas chromatography-mass spectrometry.	2008	18997384
Causal agents of photoallergic contact dermatitis diagnosed in the national institute of dermatology of Colombia.	2006-08	16869867
[Photoaggravated contact allergy and contact photoallergy caused by ketoprofen: 19 cases].	2001-10	11907961

Patents

Sample Use Guides

In Vivo Use Guide

280 patients exhibiting photosensitivity and other patients suspected of sunscreen dermatitis were patch and photo-patch tested with a pre-selected series of relevant contact allergens and photo-allergens, including Mexenone. Fifteen of the 280 patients (5%) had posative allergic reactions; 3 of them were allergic to more than one agent. The most frequent contact allergens were hydroxy methoxy methyl benzophenone (Mexenone), followed by isopropyl dibenzoylmethane (Eusolex 8020/8021), octyl dimethyl para-aminobenzoate (Escalol 507).

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:22:43 GMT 2025` Edited by `admin` on `Mon Mar 31 18:22:43 GMT 2025`
Record UNII	ET1UGF4A0B
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BENZOPHENONE-10

Preferred Name

English

MEXENONE

Official Name

English

NSC-760432

Code

English

Mexenone [WHO-DD]

Common Name

English

MEXENONE [MI]

Common Name

English

mexenone [INN]

Common Name

English

2-HYDROXY-4-METHOXY-4'-METHYLBENZOPHENONE

Systematic Name

English

MEXENONE [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C851