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Details

Stereochemistry RACEMIC
Molecular Formula C15H22O3
Molecular Weight 250.3334
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OCTISALATE

SMILES

CCCCC(CC)COC(=O)C1=C(O)C=CC=C1

InChI

InChIKey=FMRHJJZUHUTGKE-UHFFFAOYSA-N
InChI=1S/C15H22O3/c1-3-5-8-12(4-2)11-18-15(17)13-9-6-7-10-14(13)16/h6-7,9-10,12,16H,3-5,8,11H2,1-2H3

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including: http://www.skincancer.org/prevention/sun-protection/sunscreen/the-skin-cancer-foundations-guide-to-sunscreens http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=352.50 http://www.ncbi.nlm.nih.gov/pubmed/16956469

Octisalate used as an ingredient in sunscreens and cosmetics. Maximum FDA-approved concentration - 5%. Range of protection - UVB. Might develop contact allergic dermatitis

Originator

McMillan & John King
1
Sources: DOI: 10.1021/ja01228a068

Approval Year

1993
136
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Approved
8429
Unknown

Approved Use

Helps prevent sunburn. If used as directed with other sun protection measures, decreases the risk of skin cancer and early skin aging caused by the sun.
PubMed

PubMed

TitleDatePubMed
Optical spectroscopy of hydrophobic sunscreen molecules adsorbed to dielectric nanospheres.
2004 Jun
[Simultaneous determination of 9 ultraviolet absorbers in cosmetics by high-performance liquid chromatography].
2007
Fragrance material review on ethyl hexyl salicylate.
2007
Study of some UV filters stability in chlorinated water and identification of halogenated by-products by gas chromatography-mass spectrometry.
2008 Jan 18
Simultaneous determination of UV filters and polycyclic musks in aqueous samples by solid-phase microextraction and gas chromatography-mass spectrometry.
2010 Oct 22
Patents

Patents

US20080003245 A1
1
US20130095088 A1
1
US6048517 A
1

Sample Use Guides

In Vivo Use Guide
Apply liberally 15 minutes before sun exposure. Reapply at least every 2 hours
Route of Administration: Topical
In Vitro Use Guide
When applied as a finite dose in an oil-in-water emulsion vehicle containing 5% (w/w) octyl salicylate, the average total absorption of 14C over 48 hr was 0.65+/-0.16% of the applied dose.
Name Type Language
OCTISALATE
II   INN   MART.   USAN   USP   USP-RS   VANDF   WHO-DD  
INN   USAN  
Official Name English
OCTYL SALICYLATE [VANDF]
Common Name English
ETHYLHEXYL SALICYLATE [INCI]
Common Name English
NSC-46151
Code English
Octisalate [WHO-DD]
Common Name English
2-Ethylhexyl salicylate
Systematic Name English
OCTISALATE [USP MONOGRAPH]
Common Name English
OCTISALATE [USP-RS]
Common Name English
OCTISALATE [VANDF]
Common Name English
NEO HELIOPAN
Brand Name English
OCTISALATE [MART.]
Common Name English
ESCALOL
Brand Name English
BENZOIC ACID, 2-HYDROXY-, 2-ETHYLHEXYL ESTER
Common Name English
OCTISALATE [USAN]
Common Name English
OCTYL SALICYLATE [MI]
Common Name English
octisalate [INN]
Common Name English
ETHYLHEXYL SALICYLATE [VANDF]
Common Name English
OCTISALATE [II]
Common Name English
ETHYL HEXYL SALICYLATE
Common Name English
OCTYL SALICYLATE
MI   VANDF  
Systematic Name English
ETHYLHEXYL SALICYLATE
INCI   VANDF  
INCI  
Official Name English
UVINUL
Brand Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 11276
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
CFR 21 CFR 352.20
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
NCI_THESAURUS C851
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
CFR 21 CFR 352.10
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
Code System Code Type Description
WIKIPEDIA
OCTYL SALICYLATE
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
PRIMARY
NSC
46151
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
PRIMARY
CAS
118-60-5
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
PRIMARY
RXCUI
91327
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
PRIMARY
FDA UNII
4X49Y0596W
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
PRIMARY
DRUG BANK
DB11062
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
PRIMARY
SMS_ID
100000085914
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
PRIMARY
MERCK INDEX
m8130
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
PRIMARY Merck Index
RXCUI
236880
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
ALTERNATIVE
INN
7940
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
PRIMARY
DRUG CENTRAL
4241
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
PRIMARY
USAN
KK-120
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
PRIMARY
NCI_THESAURUS
C77134
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
PRIMARY
EPA CompTox
DTXSID7040734
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
PRIMARY
DAILYMED
4X49Y0596W
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
PRIMARY
ChEMBL
CHEMBL1329203
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
PRIMARY
PUBCHEM
8364
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
PRIMARY
ECHA (EC/EINECS)
204-263-4
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
PRIMARY
RS_ITEM_NUM
1477943
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
PRIMARY
EVMPD
SUB03486MIG
Created by admin on Sat Dec 16 05:42:44 UTC 2023 , Edited by admin on Sat Dec 16 05:42:44 UTC 2023
PRIMARY
ACTIVE MOIETY
Structure of OCTISALATE
NIH
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