OCTISALATE

Details

Stereochemistry	RACEMIC
Molecular Formula	C15H22O3
Molecular Weight	250.3334
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCC(CC)COC(=O)C1=C(O)C=CC=C1

InChI

InChIKey=FMRHJJZUHUTGKE-UHFFFAOYSA-N

InChI=1S/C15H22O3/c1-3-5-8-12(4-2)11-18-15(17)13-9-6-7-10-14(13)16/h6-7,9-10,12,16H,3-5,8,11H2,1-2H3

HIDE SMILES / InChI

Description
Sources: http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm079686.pdf
Curator's Comment: description was created based on several sources, including: http://www.skincancer.org/prevention/sun-protection/sunscreen/the-skin-cancer-foundations-guide-to-sunscreens http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=352.50 http://www.ncbi.nlm.nih.gov/pubmed/16956469

Octisalate used as an ingredient in sunscreens and cosmetics. Maximum FDA-approved concentration - 5%. Range of protection - UVB. Might develop contact allergic dermatitis

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Photosensitivity Disorders 1 Sources: http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm079686.pdf https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=97628e66-1550-43b9-ba1c-c2202049e8f5	Preventing		Approved 8429	Unknown Approved Use Helps prevent sunburn. If used as directed with other sun protection measures, decreases the risk of skin cancer and early skin aging caused by the sun.

PubMed

Title	Date	PubMed
Optical spectroscopy of hydrophobic sunscreen molecules adsorbed to dielectric nanospheres.	2004 Jun	15291305
Eco-friendly methodologies for the synthesis of some aromatic esters, well-known cosmetic ingredients.	2005 Feb	18492177
Evaluation of the photostability of different UV filter combinations in a sunscreen.	2006 Jan 13	16289662
A new method to test the effectiveness of sunscreen ingredients in a novel nano-surface skin cell mimic.	2006 Nov-Dec	17017843
Octyl salicylate: a new contact sensitivity.	2007 Jan	17177714
Sunscreens cause coral bleaching by promoting viral infections.	2008 Apr	18414624
Sensitive determination of salicylate and benzophenone type UV filters in water samples using solid-phase microextraction, derivatization and gas chromatography tandem mass spectrometry.	2009 Apr 6	19298877
Determination of selected UV filters in indoor dust by matrix solid-phase dispersion and gas chromatography-tandem mass spectrometry.	2009 Jul 31	19539293
Allergic contact dermatitis from ethylhexyl salicylate and other salicylates.	2010 Mar-Apr	20233542
Simultaneous determination of UV filters and polycyclic musks in aqueous samples by solid-phase microextraction and gas chromatography-mass spectrometry.	2010 Oct 22	20580369

Patents

Sample Use Guides

In Vivo Use Guide

Apply liberally 15 minutes before sun exposure. Reapply at least every 2 hours

Route of Administration: Topical

In Vitro Use Guide

When applied as a finite dose in an oil-in-water emulsion vehicle containing 5% (w/w) octyl salicylate, the average total absorption of 14C over 48 hr was 0.65+/-0.16% of the applied dose.

Name

Type

Language

OCTISALATE

Official Name

English

OCTYL SALICYLATE [VANDF]

Common Name

English

ETHYLHEXYL SALICYLATE [INCI]

Common Name

English

NSC-46151

Code

English

Octisalate [WHO-DD]

Common Name

English

2-Ethylhexyl salicylate

Systematic Name

English

OCTISALATE [USP MONOGRAPH]

Common Name

English

OCTISALATE [USP-RS]

Common Name

English

OCTISALATE [VANDF]

Common Name

English

NEO HELIOPAN

Brand Name

English

OCTISALATE [MART.]

Common Name

English

ESCALOL

Brand Name

English

BENZOIC ACID, 2-HYDROXY-, 2-ETHYLHEXYL ESTER

Common Name

English

OCTISALATE [USAN]

Common Name

English

OCTYL SALICYLATE [MI]

Common Name

English

octisalate [INN]

Common Name

English

ETHYLHEXYL SALICYLATE [VANDF]

Common Name

English

OCTISALATE [II]

Common Name

English

ETHYL HEXYL SALICYLATE

Common Name

English

OCTYL SALICYLATE

Systematic Name

English

ETHYLHEXYL SALICYLATE

Official Name

English

UVINUL

Brand Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

11276