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Details

Stereochemistry ACHIRAL
Molecular Formula C41H50N6O2
Molecular Weight 658.8747
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BISOCTRIZOLE

SMILES

CC(C)(C)CC(C)(C)C1=CC(CC2=CC(=CC(N3N=C4C=CC=CC4=N3)=C2O)C(C)(C)CC(C)(C)C)=C(O)C(=C1)N5N=C6C=CC=CC6=N5

InChI

InChIKey=FQUNFJULCYSSOP-UHFFFAOYSA-N
InChI=1S/C41H50N6O2/c1-38(2,3)24-40(7,8)28-20-26(36(48)34(22-28)46-42-30-15-11-12-16-31(30)43-46)19-27-21-29(41(9,10)25-39(4,5)6)23-35(37(27)49)47-44-32-17-13-14-18-33(32)45-47/h11-18,20-23,48-49H,19,24-25H2,1-10H3

HIDE SMILES / InChI

Molecular Formula C41H50N6O2
Molecular Weight 658.8747
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Bisoctrizole (Tinosorb M) is a hybrid type sun blocking agent acting as both chemical and physical sunscreen. Bisoctrizole is a hybrid UV absorber, the only organic UV filter produced and microfine organic particles (< 200 nm), like microfine zinc oxide and titanium dioxide. Where other organic UV absorbers need to be dissolved in either the oil or water phase, bisoctrizole dissolves poorly in both. It covers both UVA and UVB range. Furthermore, it does not degrade under sunlight and is not significantly absorbed into the skin. It appear highly compatible with many other common sun blocking agents. Overall, it appears to have a good safety profile, even though current safety data are insufficient and long-term human safety studies are lacking. Unlike some other organic sunscreen actives, it shows no estrogenic effects in vitro. Bisoctrizole is not approved by the U.S. Food and Drug Administration (FDA), but is approved in the EU and other parts of the world. Bisoctrizole is highly stable and also has a stabilizing effect on other UV absorbers, particularly the UVB blocker octyl methoxycinnamate (octinoxate). Bisoctrizole appears to be relatively non-toxic and rarely causes skin irritation. As with many synthetic chemicals, it is unclear whether bisoctrizole may produce low-level skin damage or systemic effects with long-term use. Considering that bisoctrizole is stable, poorly soluble and minimally absorbed by the skin, the risks appear to be low. Still, more research is on bisoctrizole safety is needed.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Tinosorb M

Approved Use

Unknown

Launch Date

1999
PubMed

PubMed

TitleDatePubMed
Addressing technical challenges associated with the FDA's proposed rules for the UVA in vitro testing procedure.
2009 Nov-Dec
Patents

Sample Use Guides

sunscreen
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:48:21 GMT 2023
Edited
by admin
on Fri Dec 15 15:48:21 GMT 2023
Record UNII
8NT850T0YS
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BISOCTRIZOLE
INN   MART.   MI   USAN   USP   USP-RS  
USAN   INN  
Official Name English
bisoctrizole [INN]
Common Name English
BISOCTRIZOLE [USP MONOGRAPH]
Common Name English
FAT-75634
Code English
BISOCTRIZOLE [USP-RS]
Common Name English
NSC-759873
Code English
BISOCTRIZOLE [USAN]
Common Name English
2,2'-METHYLENEBIS(6-(2-BENZOTRIAZOLYL)-4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL
Common Name English
METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL [INCI]
Common Name English
FAT 75'634
Code English
MBBT
Code English
2,2'-METHYLENEBIS(6-(2-BENZOTRIAZOLYL)-4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL)
Common Name English
BISOCTRIZOLE [MI]
Common Name English
METHYLENE BIS-BENZOTRIAZOLYL TETRAMETHYLBUTYLPHENOL
INCI  
INCI  
Official Name English
BISOCTRIZOLE [MART.]
Common Name English
PHENOL, 2,2'-METHYLENEBIS(6-(2H-BENZOTRIALZOL-2-YL)-4-(1,1,3,3-TETRAMETHYLBUTYL)-
Common Name English
Bisoctrizole [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C851
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
EU-Orphan Drug EU/3/05/262
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 234
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 532
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 652
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
FDA ORPHAN DRUG 199204
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
Code System Code Type Description
USAN
QQ-42
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
PRIMARY
EPA CompTox
DTXSID2046703
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
PRIMARY
PUBCHEM
3571576
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
PRIMARY
NSC
759873
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
PRIMARY
MERCK INDEX
m2564
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
PRIMARY Merck Index
FDA UNII
8NT850T0YS
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
PRIMARY
RS_ITEM_NUM
1075677
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
PRIMARY
DRUG BANK
DB11262
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
PRIMARY
RXCUI
1310510
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
PRIMARY RxNorm
INN
8586
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
PRIMARY
CAS
103597-45-1
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
PRIMARY
EVMPD
SUB87952
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
PRIMARY
SMS_ID
100000139401
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
PRIMARY
NCI_THESAURUS
C65266
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
PRIMARY
DRUG CENTRAL
3031
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
PRIMARY
WIKIPEDIA
BISOCTRIZOLE
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
PRIMARY
DAILYMED
8NT850T0YS
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
PRIMARY
ChEMBL
CHEMBL2104957
Created by admin on Fri Dec 15 15:48:21 GMT 2023 , Edited by admin on Fri Dec 15 15:48:21 GMT 2023
PRIMARY
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