OCTISALATE

Details

Stereochemistry	RACEMIC
Molecular Formula	C15H22O3
Molecular Weight	250.3334
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCC(CC)COC(=O)C1=CC=CC=C1O

InChI

InChIKey=FMRHJJZUHUTGKE-UHFFFAOYSA-N

InChI=1S/C15H22O3/c1-3-5-8-12(4-2)11-18-15(17)13-9-6-7-10-14(13)16/h6-7,9-10,12,16H,3-5,8,11H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C15H22O3
Molecular Weight	250.3334
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm079686.pdf
Curator's Comment: description was created based on several sources, including: http://www.skincancer.org/prevention/sun-protection/sunscreen/the-skin-cancer-foundations-guide-to-sunscreens http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=352.50 http://www.ncbi.nlm.nih.gov/pubmed/16956469

Octisalate used as an ingredient in sunscreens and cosmetics. Maximum FDA-approved concentration - 5%. Range of protection - UVB. Might develop contact allergic dermatitis

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Photosensitivity Disorders 1 Sources: http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm079686.pdf https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=97628e66-1550-43b9-ba1c-c2202049e8f5	Preventing		Approved 8583	Unknown Approved Use Helps prevent sunburn. If used as directed with other sun protection measures, decreases the risk of skin cancer and early skin aging caused by the sun.

C_max

Value	Dose	Co-administered	Analyte	Population
1.3 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² single, transdermal dose: 2 mg/cm² route of administration: Transdermal experiment type: SINGLE co-administered: AVOBENZONE	AVOBENZONE	OCTISALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
5.1 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² 4 times / day multiple, transdermal dose: 2 mg/cm² route of administration: Transdermal experiment type: MULTIPLE co-administered: AVOBENZONE	AVOBENZONE	OCTISALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
1.4 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² single, transdermal dose: 2 mg/cm² route of administration: Transdermal experiment type: SINGLE co-administered: AVOBENZONE	AVOBENZONE	OCTISALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
5.8 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² 4 times / day multiple, transdermal dose: 2 mg/cm² route of administration: Transdermal experiment type: MULTIPLE co-administered: AVOBENZONE	AVOBENZONE	OCTISALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
0.7 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² single, transdermal dose: 2 mg/cm² route of administration: Transdermal experiment type: SINGLE co-administered: AVOBENZONE	AVOBENZONE	OCTISALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4.6 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² 4 times / day multiple, transdermal dose: 2 mg/cm² route of administration: Transdermal experiment type: MULTIPLE co-administered: AVOBENZONE	AVOBENZONE	OCTISALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
12 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² single, transdermal dose: 2 mg/cm² route of administration: Transdermal experiment type: SINGLE co-administered: AVOBENZONE	AVOBENZONE	OCTISALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
67.9 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² 4 times / day multiple, transdermal dose: 2 mg/cm² route of administration: Transdermal experiment type: MULTIPLE co-administered: AVOBENZONE	AVOBENZONE	OCTISALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
14.7 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² single, transdermal dose: 2 mg/cm² route of administration: Transdermal experiment type: SINGLE co-administered: AVOBENZONE	AVOBENZONE	OCTISALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
76.9 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² 4 times / day multiple, transdermal dose: 2 mg/cm² route of administration: Transdermal experiment type: MULTIPLE co-administered: AVOBENZONE	AVOBENZONE	OCTISALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4.5 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² single, transdermal dose: 2 mg/cm² route of administration: Transdermal experiment type: SINGLE co-administered: AVOBENZONE	AVOBENZONE	OCTISALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
54 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² 4 times / day multiple, transdermal dose: 2 mg/cm² route of administration: Transdermal experiment type: MULTIPLE co-administered: AVOBENZONE	AVOBENZONE	OCTISALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
37.4 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² single, transdermal dose: 2 mg/cm² route of administration: Transdermal experiment type: SINGLE co-administered: AVOBENZONE	AVOBENZONE	OCTISALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
37.4 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² 4 times / day multiple, transdermal dose: 2 mg/cm² route of administration: Transdermal experiment type: MULTIPLE co-administered: AVOBENZONE	AVOBENZONE	OCTISALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
27.3 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² single, transdermal dose: 2 mg/cm² route of administration: Transdermal experiment type: SINGLE co-administered: AVOBENZONE	AVOBENZONE	OCTISALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
27.3 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² 4 times / day multiple, transdermal dose: 2 mg/cm² route of administration: Transdermal experiment type: MULTIPLE co-administered: AVOBENZONE	AVOBENZONE	OCTISALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
77.1 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² single, transdermal dose: 2 mg/cm² route of administration: Transdermal experiment type: SINGLE co-administered: AVOBENZONE	AVOBENZONE	OCTISALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
77.1 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/31961417/	2 mg/cm² 4 times / day multiple, transdermal dose: 2 mg/cm² route of administration: Transdermal experiment type: MULTIPLE co-administered: AVOBENZONE	AVOBENZONE	OCTISALATE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

PubMed

Title	Date	PubMed
Simultaneous determination of UV filters and polycyclic musks in aqueous samples by solid-phase microextraction and gas chromatography-mass spectrometry.	2010-10-22	20580369
Allergic contact dermatitis from ethylhexyl salicylate and other salicylates.	2010-03-18	20233542
Determination of selected UV filters in indoor dust by matrix solid-phase dispersion and gas chromatography-tandem mass spectrometry.	2009-07-31	19539293
Sensitive determination of salicylate and benzophenone type UV filters in water samples using solid-phase microextraction, derivatization and gas chromatography tandem mass spectrometry.	2009-04-06	19298877
Sunscreens cause coral bleaching by promoting viral infections.	2008-04	18414624
Study of some UV filters stability in chlorinated water and identification of halogenated by-products by gas chromatography-mass spectrometry.	2008-01-18	18067901
Fluorescence dynamics of three UV-B sunscreens.	2008-01	17963026
Octyl salicylate: a new contact sensitivity.	2007-01	17177714
[Simultaneous determination of 9 ultraviolet absorbers in cosmetics by high-performance liquid chromatography].	2007	18220048
Fragrance material review on ethyl hexyl salicylate.	2007	18031898
Fragrance material review on trans-2-hexenyl salicylate.	2007	18031887
A new method to test the effectiveness of sunscreen ingredients in a novel nano-surface skin cell mimic.	2006-10-05	17017843
Evaluation of the photostability of different UV filter combinations in a sunscreen.	2006-01-13	16289662
Eco-friendly methodologies for the synthesis of some aromatic esters, well-known cosmetic ingredients.	2005-02	18492177
Optical spectroscopy of hydrophobic sunscreen molecules adsorbed to dielectric nanospheres.	2004-06	15291305
There is no influence of a temperature rise on in vivo adsorption of UV filters into the stratum corneum.	2001-10	11532370

Patents

Sample Use Guides

In Vivo Use Guide

Apply liberally 15 minutes before sun exposure. Reapply at least every 2 hours

Route of Administration: Topical

In Vitro Use Guide

When applied as a finite dose in an oil-in-water emulsion vehicle containing 5% (w/w) octyl salicylate, the average total absorption of 14C over 48 hr was 0.65+/-0.16% of the applied dose.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:32:26 GMT 2025` Edited by `admin` on `Mon Mar 31 21:32:26 GMT 2025`
Record UNII	4X49Y0596W
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

OCTISALATE

Official Name

English

ETHYLHEXYL SALICYLATE

Preferred Name

English

OCTYL SALICYLATE [VANDF]

Common Name

English

NSC-46151

Code

English

Octisalate [WHO-DD]

Common Name

English

2-Ethylhexyl salicylate

Systematic Name

English

OCTISALATE [USP MONOGRAPH]

Common Name

English

OCTISALATE [USP-RS]

Common Name

English

OCTISALATE [VANDF]

Common Name

English

NEO HELIOPAN

Brand Name

English

OCTISALATE [MART.]

Common Name

English

ESCALOL

Brand Name

English

BENZOIC ACID, 2-HYDROXY-, 2-ETHYLHEXYL ESTER

Common Name

English

OCTISALATE [USAN]

Common Name

English

OCTYL SALICYLATE [MI]

Common Name

English

octisalate [INN]

Common Name

English

ETHYLHEXYL SALICYLATE [VANDF]

Common Name

English

OCTISALATE [II]

Common Name

English

ETHYL HEXYL SALICYLATE

Common Name

English

OCTYL SALICYLATE

Systematic Name

English

UVINUL

Brand Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

11276