Isoamyl p-Methoxycinnamate (Amiloxate) is an organic compound that absorbs ultraviolet (UV) light, which is an important cause of premature aging of the skin and in the development of melanoma and other forms of skin cancer. In Europe, Isoamyl p-Methoxycinnamate is an approved UV filter, which means the ingredient can be added to sunscreen products that are designed to protect the skin from the sun. In Europe, sunscreen products are considered cosmetic products. In the United States, sunscreen products are Over-the-Counter (OTC) drugs and only certain ingredients have been approved by the Food and Drug Administration (FDA) for use in these products. In assessing sunscreen active ingredients, the FDA reviews both safety and efficacy. The safety and efficacy of Isoamyl p-Methoxycinnamate has not yet been reviewed for sunscreen use by the FDA and it cannot be used in sunscreen drug products. For cosmetics in the United States, Isoamyl p-Methoxycinnamate can be used as a UV light absorber. In this case, the ingredient serves to protect the product from deterioration by absorbing, reflecting, or scattering UV light. It is usually combined with other ingredients in sunscreen products. But unless it is combined with ingredients that absorb UVA rays, it cannot provide enough protection on its own.

Drometrizole is a benzotriazole derivative used as an ultraviolet (UV) light absorber and stabilizer in cosmetics. Drometrizole is used widely as a UV absorber and stabilizer in plastics, polyesters, celluloses, acrylates, dyes, rubber, synthetic and natural fibers, waxes, detergent solutions, and orthodontic adhesives. It is similarly used in agricultural products and insecticides. Drometrizole is approved as an indirect food additive for use as an antioxidant and/or stabilizer in polymers. Short-term studies using rats reported liver weight increases, increases in the activities of enzymes aminopyrine N-demethylase, and UDP glucuronosyl- transferase, but no significant effects were noted in the activities of acid hydrolases or in hepatocyte organelles. Drometrizole and products containing Drometrizole were nontoxic in acute oral, inhalation, and dermal studies using animals. Although there are case reports in which Drometrizole was considered the sensitizing agent, clinical tests of cosmetic products containing 0.03% to 1.0% Drometrizole produced no irritation, sensitization, photosensitization, or phototoxicity in a total of 436 subjects.

Bemotrizinol (INN/USAN, INCI bis-ethylhexyloxyphenol methoxyphenyl triazine) is an oil-soluble organic compound that is added to sunscreens to absorb UV rays. It is marketed as Tinosorb S by BASF and as Escalol S by Ashland Inc. Bemotrizinol is a broad-spectrum UV absorber, absorbing UVB as well as UVA rays. It has two absorption peaks at 310 and 340 nm. It is highly photostable. Even after 50 MEDs (minimal erythemal doses) 98.4% remains intact. It helps prevent the photodegradation of other sunscreen actives like avobenzone. Furthermore, its presense can at least partially protect less photostable UV blockers (e.g. UVA-blocker avobenzone) from degradation. It is approved in Europe and Australia but not in the USA. Unlike some other organic sunscreen agents, bemotrizinol has not been shown to have hormone-like (estrogenic) effects in cell cultures. Bemotrizinol appears to be relatively non-toxic and rarely causes skin irritation. However, as with many synthetic chemicals, it is unclear whether bemotrizinol may produce low-level skin damage and/or systemic effects with long-term use.

Ensulizole (INN) (phenylbenzimidazole sulfonic acid) is a common sunscreen agent. In 1999, the United States Food and Drug Administration regulated that the name ensulizole be used on sunscreen labels in the United States. It is a selective UVB filter, allowing almost all UVA transmission. The scope of UVB is 290 to 340 nanometers whereas the UVA range is 320 to 400 nanometers. For better UVA protection, it must be paired with avobenzone, titanium dioxide, or zinc oxide; outside of the United States it can also be paired with a UV absorber of the Tinosorb or Mexoryl types. Because is water-soluble, it has the characteristic of feeling lighter on skin. As such, it is often used in sunscreen lotions or moisturizers whose aesthetic goal is a non-greasy finish. The free acid is poorly soluble in water, so it is only used as its soluble salts

Bisoctrizole (Tinosorb M) is a hybrid type sun blocking agent acting as both chemical and physical sunscreen. Bisoctrizole is a hybrid UV absorber, the only organic UV filter produced and microfine organic particles (< 200 nm), like microfine zinc oxide and titanium dioxide. Where other organic UV absorbers need to be dissolved in either the oil or water phase, bisoctrizole dissolves poorly in both. It covers both UVA and UVB range. Furthermore, it does not degrade under sunlight and is not significantly absorbed into the skin. It appear highly compatible with many other common sun blocking agents. Overall, it appears to have a good safety profile, even though current safety data are insufficient and long-term human safety studies are lacking. Unlike some other organic sunscreen actives, it shows no estrogenic effects in vitro. Bisoctrizole is not approved by the U.S. Food and Drug Administration (FDA), but is approved in the EU and other parts of the world. Bisoctrizole is highly stable and also has a stabilizing effect on other UV absorbers, particularly the UVB blocker octyl methoxycinnamate (octinoxate). Bisoctrizole appears to be relatively non-toxic and rarely causes skin irritation. As with many synthetic chemicals, it is unclear whether bisoctrizole may produce low-level skin damage or systemic effects with long-term use. Considering that bisoctrizole is stable, poorly soluble and minimally absorbed by the skin, the risks appear to be low. Still, more research is on bisoctrizole safety is needed.

MENTHYL SALICYLATE is an active component of COLD SPOT POINT RELIEF gel, which is indicated for temporary relief of minor aches and pains of the muscles and joints associated with simple backache, arthritis, bruises, strains and/or sprains.

Homosalate is used as a broad-band UV filter in concentrations of up to 10% in the EU or 15% depending upon where the product is used (e.g. in the USA) in sunscreen products alone or in combination with other UV absorbers to protect the skin against harmful effects of the UV radiation.

Octisalate used as an ingredient in sunscreens and cosmetics. Maximum FDA-approved concentration - 5%. Range of protection - UVB. Might develop contact allergic dermatitis

Mexenone is a benzophenone-derived UV absorbing compound used in sunscreen cosmetics such as creams, lotions, lipsticks and sun oils. It is not uncommon for Mexone and other related benzophenones to cause an allergic reaction when applied to the skin.

Bumetrizole is an ultraviolet light absorber (UVA) of the hydroxyphenyl benzotriazole class, which imparts outstanding light stability to plastics and other organic substrates. Bumetrizole is also approved by the FDA as a stabilizer in polymers used in producing, manufacturing, packaging, processing, and transporting food. Bumetrizole has a wide range of indirect food approvals in polyolefins. It has a low volatility at high temperatures and high resistance to thermal degradation and can, therefore, be used without significant loss or decomposition in the polyolefin compounding and molding processes.