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Details

Stereochemistry ACHIRAL
Molecular Formula C15H20O3
Molecular Weight 248.3175
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of AMILOXATE

SMILES

COC1=CC=C(\C=C\C(=O)OCCC(C)C)C=C1

InChI

InChIKey=UBNYRXMKIIGMKK-RMKNXTFCSA-N
InChI=1S/C15H20O3/c1-12(2)10-11-18-15(16)9-6-13-4-7-14(17-3)8-5-13/h4-9,12H,10-11H2,1-3H3/b9-6+

HIDE SMILES / InChI

Molecular Formula C15H20O3
Molecular Weight 248.3175
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Isoamyl p-Methoxycinnamate (Amiloxate) is an organic compound that absorbs ultraviolet (UV) light, which is an important cause of premature aging of the skin and in the development of melanoma and other forms of skin cancer. In Europe, Isoamyl p-Methoxycinnamate is an approved UV filter, which means the ingredient can be added to sunscreen products that are designed to protect the skin from the sun. In Europe, sunscreen products are considered cosmetic products. In the United States, sunscreen products are Over-the-Counter (OTC) drugs and only certain ingredients have been approved by the Food and Drug Administration (FDA) for use in these products. In assessing sunscreen active ingredients, the FDA reviews both safety and efficacy. The safety and efficacy of Isoamyl p-Methoxycinnamate has not yet been reviewed for sunscreen use by the FDA and it cannot be used in sunscreen drug products. For cosmetics in the United States, Isoamyl p-Methoxycinnamate can be used as a UV light absorber. In this case, the ingredient serves to protect the product from deterioration by absorbing, reflecting, or scattering UV light. It is usually combined with other ingredients in sunscreen products. But unless it is combined with ingredients that absorb UVA rays, it cannot provide enough protection on its own.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Determination of sixteen UV filters in suncare formulations by high-performance liquid chromatography.
2004 Sep 17
Eco-friendly methodologies for the synthesis of some aromatic esters, well-known cosmetic ingredients.
2005 Feb
Photoallergic contact dermatitis caused by ultraviolet filters in different sunscreens.
2008 Nov
Determination and validation of six sunscreen agents in suncare products by UPLC and HPLC.
2008 Nov-Dec
Photoallergic contact dermatitis due to isoamyl-p-methoxycinnamate.
2009
Determination of selected UV filters in indoor dust by matrix solid-phase dispersion and gas chromatography-tandem mass spectrometry.
2009 Jul 31
Validation of HPLC method for the simultaneous and quantitative determination of 12 UV-filters in cosmetics.
2010 Feb
Patents

Sample Use Guides

Sunscreen cream
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:56:28 GMT 2023
Edited
by admin
on Fri Dec 15 15:56:28 GMT 2023
Record UNII
376KTP06K8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AMILOXATE
INN   MART.   USAN   USP   USP-RS  
INN   USAN  
Official Name English
AMILOXATE [USP MONOGRAPH]
Common Name English
amiloxate [INN]
Common Name English
Amiloxate [WHO-DD]
Common Name English
AMILOXATE [MART.]
Common Name English
ISOAMYL METHOXYCINNAMATE
Systematic Name English
AMILOXATE [MI]
Common Name English
AMILOXATE [USP-RS]
Common Name English
NSC-408332
Code English
AMILOXATE [USAN]
Common Name English
AMILOXATE [USP IMPURITY]
Common Name English
E-1000
Code English
ISOAMYL P-METHOXYCINNAMATE
INCI  
INCI  
Official Name English
4-METHOXYCINNAMIC ACID, ISOAMYL ESTER
Common Name English
ISOAMYL 4-METHOXYCINNAMATE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C851
Created by admin on Fri Dec 15 15:56:28 GMT 2023 , Edited by admin on Fri Dec 15 15:56:28 GMT 2023
Code System Code Type Description
MERCK INDEX
m11779
Created by admin on Fri Dec 15 15:56:28 GMT 2023 , Edited by admin on Fri Dec 15 15:56:28 GMT 2023
PRIMARY
USAN
LL-21
Created by admin on Fri Dec 15 15:56:28 GMT 2023 , Edited by admin on Fri Dec 15 15:56:28 GMT 2023
PRIMARY
MESH
C077647
Created by admin on Fri Dec 15 15:56:28 GMT 2023 , Edited by admin on Fri Dec 15 15:56:28 GMT 2023
PRIMARY
EPA CompTox
DTXSID1046055
Created by admin on Fri Dec 15 15:56:28 GMT 2023 , Edited by admin on Fri Dec 15 15:56:28 GMT 2023
PRIMARY
DRUG CENTRAL
4500
Created by admin on Fri Dec 15 15:56:28 GMT 2023 , Edited by admin on Fri Dec 15 15:56:28 GMT 2023
PRIMARY
RXCUI
1426854
Created by admin on Fri Dec 15 15:56:28 GMT 2023 , Edited by admin on Fri Dec 15 15:56:28 GMT 2023
PRIMARY RxNorm
ChEMBL
CHEMBL1476782
Created by admin on Fri Dec 15 15:56:28 GMT 2023 , Edited by admin on Fri Dec 15 15:56:28 GMT 2023
PRIMARY
EVMPD
SUB87953
Created by admin on Fri Dec 15 15:56:28 GMT 2023 , Edited by admin on Fri Dec 15 15:56:28 GMT 2023
PRIMARY
WIKIPEDIA
Amiloxate
Created by admin on Fri Dec 15 15:56:28 GMT 2023 , Edited by admin on Fri Dec 15 15:56:28 GMT 2023
PRIMARY
PUBCHEM
1549789
Created by admin on Fri Dec 15 15:56:28 GMT 2023 , Edited by admin on Fri Dec 15 15:56:28 GMT 2023
PRIMARY
RS_ITEM_NUM
1347755
Created by admin on Fri Dec 15 15:56:28 GMT 2023 , Edited by admin on Fri Dec 15 15:56:28 GMT 2023
PRIMARY
SMS_ID
100000139402
Created by admin on Fri Dec 15 15:56:28 GMT 2023 , Edited by admin on Fri Dec 15 15:56:28 GMT 2023
PRIMARY
FDA UNII
376KTP06K8
Created by admin on Fri Dec 15 15:56:28 GMT 2023 , Edited by admin on Fri Dec 15 15:56:28 GMT 2023
PRIMARY
DRUG BANK
DB11207
Created by admin on Fri Dec 15 15:56:28 GMT 2023 , Edited by admin on Fri Dec 15 15:56:28 GMT 2023
PRIMARY
CAS
71617-10-2
Created by admin on Fri Dec 15 15:56:28 GMT 2023 , Edited by admin on Fri Dec 15 15:56:28 GMT 2023
PRIMARY
INN
7938
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PRIMARY
NSC
408332
Created by admin on Fri Dec 15 15:56:28 GMT 2023 , Edited by admin on Fri Dec 15 15:56:28 GMT 2023
PRIMARY
NCI_THESAURUS
C83532
Created by admin on Fri Dec 15 15:56:28 GMT 2023 , Edited by admin on Fri Dec 15 15:56:28 GMT 2023
PRIMARY
ECHA (EC/EINECS)
275-702-5
Created by admin on Fri Dec 15 15:56:28 GMT 2023 , Edited by admin on Fri Dec 15 15:56:28 GMT 2023
PRIMARY
DAILYMED
376KTP06K8
Created by admin on Fri Dec 15 15:56:28 GMT 2023 , Edited by admin on Fri Dec 15 15:56:28 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY