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Details

Stereochemistry ACHIRAL
Molecular Formula C15H20O3
Molecular Weight 248.3175
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of AMILOXATE

SMILES

COC1=CC=C(\C=C\C(=O)OCCC(C)C)C=C1

InChI

InChIKey=UBNYRXMKIIGMKK-RMKNXTFCSA-N
InChI=1S/C15H20O3/c1-12(2)10-11-18-15(16)9-6-13-4-7-14(17-3)8-5-13/h4-9,12H,10-11H2,1-3H3/b9-6+

HIDE SMILES / InChI

Molecular Formula C15H20O3
Molecular Weight 248.3175
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description

Isoamyl p-Methoxycinnamate (Amiloxate) is an organic compound that absorbs ultraviolet (UV) light, which is an important cause of premature aging of the skin and in the development of melanoma and other forms of skin cancer. In Europe, Isoamyl p-Methoxycinnamate is an approved UV filter, which means the ingredient can be added to sunscreen products that are designed to protect the skin from the sun. In Europe, sunscreen products are considered cosmetic products. In the United States, sunscreen products are Over-the-Counter (OTC) drugs and only certain ingredients have been approved by the Food and Drug Administration (FDA) for use in these products. In assessing sunscreen active ingredients, the FDA reviews both safety and efficacy. The safety and efficacy of Isoamyl p-Methoxycinnamate has not yet been reviewed for sunscreen use by the FDA and it cannot be used in sunscreen drug products. For cosmetics in the United States, Isoamyl p-Methoxycinnamate can be used as a UV light absorber. In this case, the ingredient serves to protect the product from deterioration by absorbing, reflecting, or scattering UV light. It is usually combined with other ingredients in sunscreen products. But unless it is combined with ingredients that absorb UVA rays, it cannot provide enough protection on its own.

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Sunscreen cream
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
376KTP06K8
Record Status Validated (UNII)
Record Version