Details
| Stereochemistry | MIXED |
| Molecular Formula | C38H49N3O5 |
| Molecular Weight | 627.8128 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCC(CC)COC1=CC=C(C(O)=C1)C2=NC(=NC(=N2)C3=CC=C(OC)C=C3)C4=C(O)C=C(OCC(CC)CCCC)C=C4
InChI
InChIKey=XVAMCHGMPYWHNL-UHFFFAOYSA-N
InChI=1S/C38H49N3O5/c1-6-10-12-26(8-3)24-45-30-18-20-32(34(42)22-30)37-39-36(28-14-16-29(44-5)17-15-28)40-38(41-37)33-21-19-31(23-35(33)43)46-25-27(9-4)13-11-7-2/h14-23,26-27,42-43H,6-13,24-25H2,1-5H3
| Molecular Formula | C38H49N3O5 |
| Molecular Weight | 627.8128 |
| Charge | 0 |
| Count |
|
| Stereochemistry | MIXED |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: description was created based on several sources, including:
https://en.wikipedia.org/wiki/Bemotrizinol
Curator's Comment: description was created based on several sources, including:
https://en.wikipedia.org/wiki/Bemotrizinol
Bemotrizinol (INN/USAN, INCI bis-ethylhexyloxyphenol methoxyphenyl triazine) is an oil-soluble organic compound that is added to sunscreens to absorb UV rays. It is marketed as Tinosorb S by BASF and as Escalol S by Ashland Inc. Bemotrizinol is a broad-spectrum UV absorber, absorbing UVB as well as UVA rays. It has two absorption peaks at 310 and 340 nm. It is highly photostable. Even after 50 MEDs (minimal erythemal doses) 98.4% remains intact. It helps prevent the photodegradation of other sunscreen actives like avobenzone. Furthermore, its presense can at least partially protect less photostable UV blockers (e.g. UVA-blocker avobenzone) from degradation. It is approved in Europe and Australia but not in the USA. Unlike some other organic sunscreen agents, bemotrizinol has not been shown to have hormone-like (estrogenic) effects in cell cultures. Bemotrizinol appears to be relatively non-toxic and rarely causes skin irritation. However, as with many synthetic chemicals, it is unclear whether bemotrizinol may produce low-level skin damage and/or systemic effects with long-term use.
Approval Year
Doses
| Dose | Population | Adverse events |
|---|---|---|
5 % single, topical Studied dose |
healthy, ADULT Health Status: healthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: |
Disc. AE: Atopic dermatitis... AEs leading to discontinuation/dose reduction: Atopic dermatitis Sources: |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Atopic dermatitis | Disc. AE | 5 % single, topical Studied dose |
healthy, ADULT Health Status: healthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: |
| Substance Class |
Chemical
Created
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admin
on
Edited
Mon Mar 31 18:17:32 GMT 2025
by
admin
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Mon Mar 31 18:17:32 GMT 2025
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PWZ1720CBH
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Validated (UNII)
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C851
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C74398
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DTXSID40896984
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m2300
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CHEMBL2104956
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SUB32134
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BEMOTRIZINOL
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1048572
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759870
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DB11206
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100000124344
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