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Search results for "Pharmacologic Substance[C1909]|Chemopreventive Agent[C1892]|Sunscreen" in comments (approximate match)
Status:
First approved in 1964
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Sulisobenzone (benzophenone-4) is an ingredient for use in sunscreens which protects the skin from damage by UVB and short-wave UVA ultraviolet light. The Food and Drug Administration (FDA) has approved the use of Benzophenone-4 as safe and effective, over-the-counter (OTC) sunscreen ingredient. Sulisobenzone is a subject to the FDA 2011 sunscreen final rule: it can be marketed without approved drug applications (without NDAs or ANDAs), must bear the statement of identity “sunscreen" and contain the information about SPF test. However it is said to be widely used in cosmetic products not labeled as sunscreens such as creams, moisturizers, shampoos and other hair care products, nail polish, lipsticks and lip balms. Sulisobenzone may cause contact dermatitis when used in cosmetics and toiletries. Benzophenone 4 is tested as 10%. It was reported that 10% sulisobenzone enhance skin penetration of the moderately lipophilic herbicide 2,4-D.
Status:
First approved in 1964
Source:
21 CFR 358A
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
Padimate O is an organic compound related to the water-soluble compound PABA (4-aminobenzoic acid) that is used as an ingredient in some sunscreens. this chemical releases free radicals, damages DNA, has estrogenic activity, and causes allergic reactions in some people. Maximum FDA-approved concentration - 8%. Range of protection - UVB.
Status:
US Previously Marketed
First approved in 1961
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Cinoxate, a cinnamate, is a potent ultraviolet absorber at 289 nm. It is approved by FDA as the active ingredient in sunscreen compositions for over-the-counter (OTC) use at concentrations up to 3% and a minimum SPF value of not less than 2 in the finished product but is rarely used It can cause photoallergic contact dermatitis.
Status:
First approved in 1952
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Digalloyl trioleate used in personal care products as an UV absorbing agent, possessed anti-oxidizing, dispersing abilities. It;s no longer available as it apparently exhibits a poor UV absorbtion profile. Researchers from the Institute of Pharmacology and Toxicology at the University of Zurich, Switzerland have found that five out of six commonly used chemical sunscreens dose the body with synthetic estrogens. And harmful chemical sunscreens include digalloyl trioleate is banned by the European Union.
Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(29) sunscreen glyceryl aminobenzoate (lisadimate, glyceryl PABA)
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
Lisadimate (glyceryl PABA), a substituted aminobenzoate, is a sunscreen with actions similar to those of aminobenzoic acid. It is effective against UVB light. Glyceryl PABA (Escalol 106), present in many popular sunscreens, is a common sensitizer which invariably cross-reacts with benzocaine; it is present in over 400 over-the-counter products. Glyceryl PABA does not appear to cross-react with the sunscreening agents amyl (Escalol 506) and octyl (Escalol 507) dimethyl PABA. Glyceryl PABA, may, on occasion, cross-react with para-aminobenzoic acid (PABA), paraphenylenediamine, aniline, and sulfa drugs. Ironically, the sunscreening agent glyceryl PABA may, itself, act as a photosensitizing agent.
Status:
US Previously Marketed
Source:
64 FR 27682 sunscreen 2-ethylhexyl-4-phenylbenzophenone-2-carboxylic acid
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
2-Ethylhexyl-4-phenyl-benzophenone carbonate (Eusolex 3573) is a component of sunscreen and possesses of ultraviolet A (UV-A) absorbing properties.
Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(29) sunscreen ethyl 4-[bis(hydroxypropyl)] aminobenzoate (roxadimate)
Source URL:
Class (Stereo):
CHEMICAL (MIXED)
Conditions:
Roxadimate was used for cracked or chapped lips. Used to reduce skin mutation and DNA damage
Status:
Possibly Marketed Outside US
Source:
71 FR 42405 sunscreen diethylhexyl butamido triazone
Source URL:
First approved in 2022
Source:
M020
Source URL:
Class (Stereo):
CHEMICAL (MIXED)
Iscotrizinol is a triazine-based organic compound that readily absorbs UVA and UVB radiation with a peak protection at 310 nm. Iscotrizinol has an excellent photostability, it preserves 90% of its effectiveness after 63 hours. Iscotrizinol is commonly found in sunscreen and other sun care products in Europe and Japan but is not approved by the FDA for marketing in the US.
Status:
Possibly Marketed Outside US
Source:
21 CFR 352
(2016)
Source URL:
First approved in 2016
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Bisdisulizole disodium (also known as disodium phenyl dibenzimidazole tetrasulfonate) under the brand name Neoheliopan AP is marketed in some Europe countries and in Australia. This compound is a part of sunscreens to absorb UVA rays.
Status:
Possibly Marketed Outside US
Source:
Unknown by Sotiropoulos, J.|El Batouti, N.
Source URL:
First approved in 2010
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
Enzacamene, ( )-[Bicyclo[2.2.1]-heptan-2-one, 1,7,7-trimethyl-3-[(4-methylphenyl)methylene]-, (1R,3E,4S)-] is one of enantiomer of Enzacamene (4-MBC) -- organic sunscreen components, that protects against UV radiation and may therefore help in the prevention of skin cancer. Enzacamene can exist as a cis-(Z)- and trans-(E)-isomer due to the exocyclic carbon-carbon (styrene) double bond. A commercial Enzacamene from a major supplier of UV filters showed the presence of only the (E)-isomer However, it is known that, upon exposure to light, (E)-4-Enzacamene is photochemically isomerized reversably to (Z)-4-Enzacamene. Both (E)- and (Z)-Enzacamene are chiral and thus consist of enantiomers (optical isomers). In a technical material and in a major brand sun lotion, Enzacamene was shown to consist entirely (>99%) of (E)-isomers and to be racemic. Wastewater showed the presence of both (E)- and (Z)-Enzacamene with a clear excess of (E)-isomers (E >Z). Untreated wastewater showed a nearly racemic composition suggesting that most if not all commercial Enzacamene is racemic. Treated wastewater indicated some excess of (R)- or (S)-stereoisomers ikely as a result of some enantioselective (bio)degradation in wastewater treatment plants. Enantiomers may show different biological behavior with respect to uptake, metabolism, and excretion and often differ in toxicity and other biological effects.