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Details

Stereochemistry ACHIRAL
Molecular Formula C13H10N2O3S
Molecular Weight 274.295
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ENSULIZOLE

SMILES

OS(=O)(=O)C1=CC=C2N=C(NC2=C1)C3=CC=CC=C3

InChI

InChIKey=UVCJGUGAGLDPAA-UHFFFAOYSA-N
InChI=1S/C13H10N2O3S/c16-19(17,18)10-6-7-11-12(8-10)15-13(14-11)9-4-2-1-3-5-9/h1-8H,(H,14,15)(H,16,17,18)

HIDE SMILES / InChI

Molecular Formula C13H10N2O3S
Molecular Weight 274.295
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Ensulizole (INN) (phenylbenzimidazole sulfonic acid) is a common sunscreen agent. In 1999, the United States Food and Drug Administration regulated that the name ensulizole be used on sunscreen labels in the United States. It is a selective UVB filter, allowing almost all UVA transmission. The scope of UVB is 290 to 340 nanometers whereas the UVA range is 320 to 400 nanometers. For better UVA protection, it must be paired with avobenzone, titanium dioxide, or zinc oxide; outside of the United States it can also be paired with a UV absorber of the Tinosorb or Mexoryl types. Because is water-soluble, it has the characteristic of feeling lighter on skin. As such, it is often used in sunscreen lotions or moisturizers whose aesthetic goal is a non-greasy finish. The free acid is poorly soluble in water, so it is only used as its soluble salts

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
ALOE SUNSCREEN

PubMed

Sample Use Guides

In Vivo Use Guide
apply liberally 15 minutes before sun exposure
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
9YQ9DI1W42
Record Status Validated (UNII)
Record Version