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Details

Stereochemistry ACHIRAL
Molecular Formula C13H9N2O3S.K
Molecular Weight 312.385
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ENSULIZOLE POTASSIUM

SMILES

[K+].[O-]S(=O)(=O)C1=CC2=C(C=C1)N=C(N2)C3=CC=CC=C3

InChI

InChIKey=YPSWUECEJGNOLY-UHFFFAOYSA-M
InChI=1S/C13H10N2O3S.K/c16-19(17,18)10-6-7-11-12(8-10)15-13(14-11)9-4-2-1-3-5-9;/h1-8H,(H,14,15)(H,16,17,18);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula K
Molecular Weight 39.0983
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C13H9N2O3S
Molecular Weight 273.287
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including: http://www.ncbi.nlm.nih.gov/pubmed/23112351

Ensulizole (INN) (phenylbenzimidazole sulfonic acid) is a common sunscreen agent. In 1999, the United States Food and Drug Administration regulated that the name ensulizole be used on sunscreen labels in the United States. It is a selective UVB filter, allowing almost all UVA transmission. The scope of UVB is 290 to 340 nanometers whereas the UVA range is 320 to 400 nanometers. For better UVA protection, it must be paired with avobenzone, titanium dioxide, or zinc oxide; outside of the United States it can also be paired with a UV absorber of the Tinosorb or Mexoryl types. Because is water-soluble, it has the characteristic of feeling lighter on skin. As such, it is often used in sunscreen lotions or moisturizers whose aesthetic goal is a non-greasy finish. The free acid is poorly soluble in water, so it is only used as its soluble salts

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
ALOE SUNSCREEN

Approved Use

Unknown

Launch Date

2011
PubMed

PubMed

TitleDatePubMed
Comparison of the hanson microette and the Van Kel apparatus for in vitro release testing of topical semisolid formulations.
2001 Oct
Photophysical and photochemical studies of 2-phenylbenzimidazole and UVB sunscreen 2-phenylbenzimidazole-5-sulfonic acid.
2002 Feb
Sensitive sequential-injection system for the determination of 2-phenylbenzimidazole-5-sulphonic acid in human urine samples using on-line solid-phase extraction coupled with fluorimetric detection.
2003 Mar 1
Novel nanotubes from a cationic surfactant and an anionic stiff aromatic counter-ion.
2006 Sep 14
Indirect fluorescent determination of selected nitro-aromatic and pharmaceutical compounds via UV-photolysis of 2-phenylbenzimidazole-5-sulfonate.
2008 Feb 15
Multiclass determination of sunscreen chemicals in water samples by liquid chromatography-tandem mass spectrometry.
2008 Feb 15
Phase behavior of aqueous mixtures of 2-phenylbenzimidazole-5-sulfonic acid and cetyltrimethylammonium bromide: hydrogels, vesicles, tubules, and ribbons.
2008 Mar 13
The sunscreen agent 2-phenylbenzimidazole-5-sulfonic acid photosensitizes the formation of oxidized guanines in cellulo after UV-A or UV-B exposure.
2010 Oct
Quantum chemical investigation and experimental verification on the aquatic photochemistry of the sunscreen 2-phenylbenzimidazole-5-sulfonic acid.
2010 Oct 1
Occurrence of xenobiotics in gray water and removal in three biological treatment systems.
2010 Sep 1
Patents

Sample Use Guides

apply liberally 15 minutes before sun exposure
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 19:57:02 GMT 2023
Edited
by admin
on Sat Dec 16 19:57:02 GMT 2023
Record UNII
058078A0QS
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ENSULIZOLE POTASSIUM
Common Name English
PHENYLBENZIMIDAZOLE SULFONIC ACID POTASSIUM SALT
Brand Name English
2-PHENYLBENZIMIDAZOLE-5-SULFONIC ACID, POTASSIUM SALT
Common Name English
POTASSIUM PHENYLBENZIMIDAZOLE SULFONATE [INCI]
Common Name English
POTASSIUM PHENYLBENZIMIDAZOLE SULFONATE
INCI  
INCI  
Official Name English
POTASSIUM 2-PHENYLBENZIMIDAZOLE-5-SULFONATE
Systematic Name English
1H-BENZIMIDAZOLE-5-SULFONIC ACID, 2-PHENYL-, MONOPOTASSIUM SALT
Common Name English
1H-BENZIMIDAZOLE-6-SULFONIC ACID, 2-PHENYL-, POTASSIUM SALT (1:1)
Common Name English
Code System Code Type Description
CAS
158099-19-5
Created by admin on Sat Dec 16 19:57:02 GMT 2023 , Edited by admin on Sat Dec 16 19:57:02 GMT 2023
PRIMARY
EPA CompTox
DTXSID80166375
Created by admin on Sat Dec 16 19:57:02 GMT 2023 , Edited by admin on Sat Dec 16 19:57:02 GMT 2023
PRIMARY
PUBCHEM
23689668
Created by admin on Sat Dec 16 19:57:02 GMT 2023 , Edited by admin on Sat Dec 16 19:57:02 GMT 2023
PRIMARY
FDA UNII
058078A0QS
Created by admin on Sat Dec 16 19:57:02 GMT 2023 , Edited by admin on Sat Dec 16 19:57:02 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY