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Approval Year

Unknown
139594
Substance Class Protein
Created
by admin
on Sat Dec 16 12:23:00 UTC 2023
Edited
by admin
on Sat Dec 16 12:23:00 UTC 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
7J9Y28299R
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
Common Name English
HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2
Common Name English
CD340
Common Name English
NEU
Common Name English
METASTATIC LYMPH NODE GENE 19 PROTEIN
Common Name English
NGL
Common Name English
TYROSINE KINASE-TYPE CELL SURFACE RECEPTOR HER2
Common Name English
PROTO-ONCOGENE NEU
Common Name English
HER2/NEU
Common Name English
ERBB2
Common Name English
P185ERBB2
Common Name English
HER-2
Common Name English
HER2
Common Name English
PROTO-ONCOGENE C-ERBB-2
Common Name English
MLN19
Common Name English
ERBB-2
Common Name English
Code System Code Type Description
FDA UNII
7J9Y28299R
Created by admin on Sat Dec 16 12:23:02 UTC 2023 , Edited by admin on Sat Dec 16 12:23:02 UTC 2023
PRIMARY
WIKIPEDIA
HER2/neu
Created by admin on Sat Dec 16 12:23:02 UTC 2023 , Edited by admin on Sat Dec 16 12:23:02 UTC 2023
PRIMARY
UNIPROT
P04626
Created by admin on Sat Dec 16 12:23:02 UTC 2023 , Edited by admin on Sat Dec 16 12:23:02 UTC 2023
PRIMARY
From To
1_4 1_31
1_140 1_170
1_173 1_182
1_177 1_190
1_198 1_205
1_202 1_213
1_214 1_222
1_218 1_230
1_233 1_242
1_246 1_273
1_277 1_289
1_293 1_309
1_312 1_316
1_320 1_345
1_453 1_482
1_489 1_498
1_493 1_506
1_509 1_518
1_522 1_538
1_541 1_554
1_545 1_562
1_565 1_574
1_578 1_601
1_604 1_612
1_608 1_620
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_46
N 1_102
N 1_165
N 1_237
N 1_508
N 1_549
N 1_607
Related Record Type Details
Structure of 4,6-QUINAZOLINEDIAMINE, N4-(3-CHLORO-4-((3-FLUOROPHENYL)METHOXY)PHENYL)-
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Structure of 2-PROPENAMIDE, N-(4-((3-CHLORO-4-HYDROXYPHENYL)AMINO)-6-QUINAZOLINYL)-
WEAK INHIBITOR->TARGET
IC50
GP-2 HER2-DERIVED, HLA-A2+ RESTRICTED PEPTIDE
ANTIGEN->TARGET
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INHIBITOR -> TARGET
Structure of PELITINIB
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ZENOCUTUZUMAB
INHIBITOR -> TARGET
IgG1 bispecific antibody with enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) activity targeting HER2 and HER3 receptors.
Trastuzumab brengitecan
INHIBITOR -> TARGET
TEZATABEP MATRAXETAN
LIGAND->TARGET
DHES-0815A
CONJUGATED TOXIN->TARGET
ZANIDATAMAB
INHIBITOR -> TARGET
Structure of POZIOTINIB
INHIBITOR -> TARGET
PERTUZUMAB DEFEROXAMINE ZIRCONIUM ZR-89
RADIOLIGAND->TARGET
MM-111
LIGAND->TARGET
Structure of N-DESMETHYL NERATINIB
INHIBITOR -> TARGET
Structure of AV-412 FREE BASE
INHIBITOR -> TARGET
IRREVERSIBLE INHIBITOR
IC50
Trastuzumab Vedotin
CONJUGATED TOXIN->TARGET
MRG002 potently inhibited proliferation of HER2 expressing cancer cells in vitro with IC50 ranged from 1.8±0.8 to 59.9±8.9 ng/mL,
AV-203
INHIBITOR -> TARGET
Structure of SPH-5030
INHIBITOR -> TARGET
IC50
Structure of N-(4-((3-CHLORO-4-((3-FLUOROPHENYL)METHOXY)PHENYL)AMINO)-6-QUINAZOLINYL)-2,3-DIHYDROXYPROPANAMIDE
WEAK INHIBITOR->TARGET
IC50
Structure of MUBRITINIB
INHIBITOR -> TARGET
Structure of CANERTINIB
INHIBITOR -> TARGET
EP-2101 COMPONENT LYS-VAL-PHE-GLY-SER-LEU-ALA-PHE-VAL
VACCINE ANTIGEN->TARGET
Structure of (3R,4R)-4-AMINO-1-((4-((3-METHOXYPHENYL)AMINO)PYRROLO(2,1-F)(1,2,4)TRIAZIN-5-YL)METHYL)-3-PIPERIDINYL .BETA.-D-GLUCOPYRANOSIDURONIC ACID
INHIBITOR -> TARGET
IC50
Structure of NERATINIB
INHIBITOR -> TARGET
DISITAMAB VEDOTIN
CONJUGATED TOXIN->TARGET
TIMIGUTUZUMAB
INHIBITOR -> TARGET
Fencabtagene Autoleucel
CYTOTOXIC T-CELL->TARGET
Structure of Sacibertinib
INHIBITOR -> TARGET
Anvatabart Pactil
LIGAND->TARGET
EP-2101 COMPONENT LYS-VAL-PHE-GLY-SER-LEU-ALA-PHE-VAL
TARGET->VACCINE ANTIGEN
GBR-1302
LIGAND->TARGET
Structure of BMS-690514
INHIBITOR -> TARGET
IC50
Structure of PYROTINIB
INHIBITOR -> TARGET
IRREVERSIBLE INHIBITOR
IC50
PERTUZUMAB
INHIBITOR -> TARGET
HER dimerization inhibitor
BINDING
ETBX-021
ANTIGEN->TARGET
Identified as a definitive diagnostic marker, key driver and therapeutic target for chordoma, a malignant tumor that arises from remnant notochordal cells lodged in the vertebrae
TRASTUZUMAB DUOCARMAZINE
INHIBITOR -> TARGET
MEDI-4276
CONJUGATED TOXIN->TARGET
Structure of VARLITINIB
INHIBITOR -> TARGET
FIDASIMTAMAB
LIGAND->TARGET
Structure of NERATINIB DIMETHYLAMINE N-OXIDE
INHIBITOR -> TARGET
Structure of AEE-788
INHIBITOR -> TARGET
Structure of ALLITINIB
INHIBITOR -> TARGET
irreversible selective inhibitor
IRREVERSIBLE INHIBITOR
IC50
DISITAMAB
INHIBITOR -> TARGET
TRASTUZUMAB CORIXETAN THORIUM TH-227
RADIOLIGAND->TARGET
CINREBAFUSP ALFA
INHIBITOR -> TARGET
Anvatabart Opadotin
CONJUGATED TOXIN->TARGET
NELIPEPIMUT-S
ANTIGEN->TARGET
Structure of EPERTINIB
INHIBITOR -> TARGET
ZANIDATAMAB ZOVODOTIN
CONJUGATED TOXIN->TARGET
Structure of AFATINIB
INHIBITOR -> TARGET
ZIRCONIUM ZR-89 TRASTUZUMAB
RADIOLIGAND->TARGET
Structure of (3R,4R)-4-AMINO-1-((4-((4-HYDROXY-3-METHOXYPHENYL)AMINO)PYRROLO(2,1-F)(1,2,4)TRIAZIN-5-YL)METHYL)-3-PIPERIDINOL
INHIBITOR -> TARGET
BMS-690514 metabolite M2 showed HER2 inhibition similar to that of BMS-690514.
IC50
Structure of NERATINIB PYRIDINE N-OXIDE
INHIBITOR -> TARGET
FS-102
INHIBITOR -> TARGET
Structure of IBRUTINIB
INHIBITOR->OFF-TARGET
IC50
Structure of TUCATINIB
INHIBITOR -> TARGET
SELECTIVE
Ki
Structure of NEPTINIB
INHIBITOR -> TARGET
TRASTUZUMAB
INHIBITOR -> TARGET
LAPULEUCEL-T
VACCINE ANTIGEN->TARGET
Structure of SAPITINIB
INHIBITOR -> TARGET
COPRELOTAMAB
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL
NIH
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