U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Jun 26 22:44:12 UTC 2021
Edited
by admin
on Sat Jun 26 22:44:12 UTC 2021
Source Materials Class ORGANISM
Source Materials Type VIRUS
Source Materials State LIVE GENETICALLY MODIFIED NON-REPLICATING
Source Materials Parent
Organism Family ADENOVIRIDAE
Organism Genus MASTADENOVIRUS
Organism Species Human mastadenovirus C
Infraspecific Type SEROTYPE
Infraspecific Name TYPE 5
Part WHOLE
Record UNII
S4MK9TOL0D
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ETBX-021
Common Name English
AD5 (E1-, E2B-)-HER2/NEU VACCINE ETBX-021
Common Name English
A HER2 PROTEIN-TARGETING ADENOVIRUS VECTOR BREAST CANCER VACCINE COMPRISED OF THE (AD5 (E1-, E2B-)-HER2/NEU) VECTOR MODIFIED BY REMOVAL OF THE E1, E2B AND E3 GENES AND INSERTION OF A MODIFIED HER2/NEU GENE
Common Name English
Code System Code Type Description
FDA UNII
S4MK9TOL0D
Created by admin on Sat Jun 26 22:44:12 UTC 2021 , Edited by admin on Sat Jun 26 22:44:12 UTC 2021
PRIMARY
CAS
2171509-20-7
Created by admin on Sat Jun 26 22:44:12 UTC 2021 , Edited by admin on Sat Jun 26 22:44:12 UTC 2021
PRIMARY
Related Record Type Details
TARGET->ANTIGEN
Identified as a definitive diagnostic marker, key driver and therapeutic target for chordoma, a malignant tumor that arises from remnant notochordal cells lodged in the vertebrae
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
PROTEIN NOT EXPRESSED (GENE DISRUPTION) viral genes early 1 EARLY E1A PROTEIN (HUMAN ADENOVIRUS 5) MW6YY4WVP4
VECTOR EXPRESSED PROTEIN UNKNOWN RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 7J9Y28299R
PROTEIN NOT EXPRESSED (GENE DISRUPTION) viral genes early 2b DNA POLYMERASE (HUMAN ADENOVIRUS 5) ETQ2WKD05X
PROTEIN NOT EXPRESSED (GENE DISRUPTION) viral genes early 2b PRETERMINAL PROTEIN (HUMAN ADENOVIRUS 5) PL0VT48B2N