Anvatabart Opadotin

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 14:19:50 GMT 2023` Edited by `admin` on `Sat Dec 16 14:19:50 GMT 2023`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	B2KH16FA7H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Anvatabart Opadotin

Official Name

English

ARX 788 [WHO-DD]

Common Name

English

gamma1 heavy chain humanized (1-449) [VH humanized (Homo sapiens IGHV3-66*01 (81.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*01, G1m17,1 (CH1 A1.4>F (pAF) (121), K120 (217) (121- 218), hinge 1-15 (219

Common Name

English

ARX788

Code

English

ARX-788 (ANTI-HER2 MAB PAF- MMAF TOXIN OXIME CONJUGATE)

Common Name

English

ANVATABART OPAFIDOTIN [USAN]

Common Name

English

anvatabart opadotin [INN]

Common Name

English

ARX-788

Code

English

Immunoglobulin G1-kappa, anti-[Homo sapiens ERBB2 (epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)], humanized monoclonal antibody; conjugated at two engineered sites via a stable

Common Name

English

Immunoglobulin G1 [121-(4-acetylphenylalanine),de-450-lysine], anti-(human epidermal growth factor receptor HER2) (human-Mus musculus monoclonal Amab788 γ1-chain), disulfide with human-Mus musculus monoclonal Amab788 κ-chain, dimer, 121,121′-dioxime

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

794820