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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 23:06:22 GMT 2025
Edited
by admin
on Tue Apr 01 23:06:22 GMT 2025
Protein Type MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type IGG1
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
B2KH16FA7H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Anvatabart Opadotin
INN   USAN  
Official Name English
ARX-788
Preferred Name English
ARX 788 [WHO-DD]
Common Name English
gamma1 heavy chain humanized (1-449) [VH humanized (Homo sapiens IGHV3-66*01 (81.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*01, G1m17,1 (CH1 A1.4>F (pAF) (121), K120 (217) (121- 218), hinge 1-15 (219
Common Name English
ARX788
Code English
ARX-788 (ANTI-HER2 MAB PAF- MMAF TOXIN OXIME CONJUGATE)
Common Name English
ANVATABART OPAFIDOTIN [USAN]
Common Name English
anvatabart opadotin [INN]
Common Name English
Immunoglobulin G1-kappa, anti-[Homo sapiens ERBB2 (epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)], humanized monoclonal antibody; conjugated at two engineered sites via a stable
Common Name English
Immunoglobulin G1 [121-(4-acetylphenylalanine),de-450-lysine], anti-(human epidermal growth factor receptor HER2) (human-Mus musculus monoclonal Amab788 ?1-chain), disulfide with human-Mus musculus monoclonal Amab788 ?-chain, dimer, 121,121?-dioxime with
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 794820
Created by admin on Tue Apr 01 23:06:22 GMT 2025 , Edited by admin on Tue Apr 01 23:06:22 GMT 2025
Code System Code Type Description
FDA UNII
B2KH16FA7H
Created by admin on Tue Apr 01 23:06:22 GMT 2025 , Edited by admin on Tue Apr 01 23:06:22 GMT 2025
PRIMARY
USAN
KL-238
Created by admin on Tue Apr 01 23:06:22 GMT 2025 , Edited by admin on Tue Apr 01 23:06:22 GMT 2025
PRIMARY
INN
12272
Created by admin on Tue Apr 01 23:06:22 GMT 2025 , Edited by admin on Tue Apr 01 23:06:22 GMT 2025
PRIMARY
SMS_ID
300000034918
Created by admin on Tue Apr 01 23:06:22 GMT 2025 , Edited by admin on Tue Apr 01 23:06:22 GMT 2025
PRIMARY
NCI_THESAURUS
C123917
Created by admin on Tue Apr 01 23:06:22 GMT 2025 , Edited by admin on Tue Apr 01 23:06:22 GMT 2025
PRIMARY
CAS
2636710-07-9
Created by admin on Tue Apr 01 23:06:22 GMT 2025 , Edited by admin on Tue Apr 01 23:06:22 GMT 2025
PRIMARY
From To
1_22 1_96
2_22 2_96
2_147 2_203
2_223 4_214
2_264 2_324
1_147 1_203
2_370 2_428
3_23 3_88
3_134 3_194
4_23 4_88
4_134 4_194
1_223 3_214
1_229 2_229
1_232 2_232
1_264 1_324
1_370 1_428
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_300
N 2_300
Related Record Type Details
RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
TARGET->CONJUGATED TOXIN
Structure of Opadotin
TOXIN -> CONJUGATE
Related Record Type Details
Anvatabart Opadotin
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_121] [2_121] SITE_SPECIFIC UNSPECIFIED SUBSTANCE
94f851be
(not in database)
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
NCATS
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