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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 20:03:26 GMT 2025
Edited
by admin
on Wed Apr 02 20:03:26 GMT 2025
Protein Type MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type IGG1|KAPPA
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
MNX9BG4BZK
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Caxmotabart Entudotin
Common Name English
H-gamma1 heavy chain humanized (1-450) [VH (Homo sapiens IGHV3-66*01 (81.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (217) (121-218), hinge 1-
Preferred Name English
immunoglobulin G1-kappa, anti-[Homo sapiens ERBB2 (receptor tyrosine-protein kinase erbB-2, epidermal growth factor receptor 2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)], humanized monoclonal antibody, conjugated on an average of two cysteinyl residu
Common Name English
caxmotabart entudotin [INN]
Common Name English
Immunoglobulin G1, anti-(human epidermal growth factor receptor HER2) (human-Mus musculus monoclonal rhuMab HER2 ?1-chain), disulfide with human-Mus musculus monoclonal rhuMab HER2 ?-chain fusion protein with peptide (GGGGGGGC), dimer, 222??,222???-bis(t
Common Name English
Code System Code Type Description
CAS
2930814-97-2
Created by admin on Wed Apr 02 20:03:26 GMT 2025 , Edited by admin on Wed Apr 02 20:03:26 GMT 2025
PRIMARY
INN
13278
Created by admin on Wed Apr 02 20:03:26 GMT 2025 , Edited by admin on Wed Apr 02 20:03:26 GMT 2025
PRIMARY
SMS_ID
300000056825
Created by admin on Wed Apr 02 20:03:26 GMT 2025 , Edited by admin on Wed Apr 02 20:03:26 GMT 2025
PRIMARY
FDA UNII
MNX9BG4BZK
Created by admin on Wed Apr 02 20:03:26 GMT 2025 , Edited by admin on Wed Apr 02 20:03:26 GMT 2025
PRIMARY
NCI_THESAURUS
C172821
Created by admin on Wed Apr 02 20:03:26 GMT 2025 , Edited by admin on Wed Apr 02 20:03:26 GMT 2025
PRIMARY
From To
2_223 4_214
1_223 3_214
4_134 4_194
4_23 4_88
3_134 3_194
3_23 3_88
1_232 2_232
1_229 2_229
2_370 2_428
2_264 2_324
2_147 2_203
2_22 2_96
1_370 1_428
1_264 1_324
1_147 1_203
1_22 1_96
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_300
N 2_300
Related Record Type Details
RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
TARGET->LIGAND
Caxmotabart
PARENT -> CONJUGATE
Related Record Type Details
Caxmotabart Entudotin
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID REMOVAL [1_450] [2_450] C-TERMINUS K LYSINE K3Z4F929H6
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
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