U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 19:56:59 GMT 2023
Edited
by admin
on Sat Dec 16 19:56:59 GMT 2023
Protein Type MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type IGG1
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
5MHN3G4T8J
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Trastuzumab brengitecan
INCI  
Official Name English
immunoglobulin G1-kappa, anti-[Homo sapiens ERBB2 (receptor tyrosine-protein kinase erbB-2, epidermal growth factor receptor 2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)], humanized monoclonal antibody, conjugated to a camptothecin derivative
Common Name English
Immunoglobulin G1 [de-450-lysine], anti-(human epidermal growth factor receptor HER2) (human-Mus musculus monoclonal BL-M07D1 γ1-chain), complex with human-Mus musculus monoclonal BL-M07D1 κ-chain, dimer, 214′′,214′′′,223,223′,229,229′,23
Common Name English
trastuzumab brengitecan [INN]
Common Name English
Code System Code Type Description
INN
12677
Created by admin on Sat Dec 16 19:56:59 GMT 2023 , Edited by admin on Sat Dec 16 19:56:59 GMT 2023
PRIMARY
FDA UNII
5MHN3G4T8J
Created by admin on Sat Dec 16 19:56:59 GMT 2023 , Edited by admin on Sat Dec 16 19:56:59 GMT 2023
PRIMARY
CAS
2761149-81-7
Created by admin on Sat Dec 16 19:56:59 GMT 2023 , Edited by admin on Sat Dec 16 19:56:59 GMT 2023
PRIMARY
From To
1_22 1_96
2_22 2_96
2_147 2_203
2_223 4_214
2_264 2_324
1_147 1_203
2_370 2_428
3_23 3_88
3_134 3_194
4_23 4_88
4_134 4_194
1_223 3_214
1_229 2_229
1_232 2_232
1_264 1_324
1_370 1_428
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_300
N 2_300
Related Record Type Details
TARGET -> INHIBITOR
PARENT -> CONJUGATE
CONJUGATE COMPONENT->CONJUGATE
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL