U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Nelipepimut-S (formerly known as E75) is an immunogenic peptide from the HER2 protein that is highly expressed in breast cancer. The NeuVax™ (Galena, OR, USA) vaccine, nelipepimut-S plus granulocyte-macrophage colony-stimulating factor, is designed for the prevention of clinical recurrences in high risk, disease-free breast cancer patients. Nelipepimut-S is being developed by Sellas Life Sciences Group. When combined with the immunoadjuvant granulocyte-macrophage colony-stimulating factor (GM-CSF), nelipepimut-S has been used as a vaccine that is capable of eliciting a robust anti-HER2 immune response. Early-phase clinical trials that enrolled women with node-positive or high-risk node-negative breast cancer who had been rendered disease free with standard of care therapy but were at risk for recurrence, demonstrated the vaccine to be safe with a suggestion of clinical benefit. Nelipepimut-S is currently being evaluated in a Phase III clinical trial.

Approval Year

PubMed

PubMed

TitleDatePubMed
Efficacy and Safety Analysis of Nelipepimut-S Vaccine to Prevent Breast Cancer Recurrence: A Randomized, Multicenter, Phase III Clinical Trial.
2019 Jul 15

Sample Use Guides

Breast Cancer: Patients received 1,000 ug Nelipepimut-S + 250 ug GM-CSF or placebo + GM-CSF monthly for 6 months, then every 6 months through 36 months.
Route of Administration: Other
Substance Class Protein
Created
by admin
on Sat Jun 26 16:29:48 UTC 2021
Edited
by admin
on Sat Jun 26 16:29:48 UTC 2021
Protein Type PEPTIDE
Protein Sub Type T-CELL ANTIGEN
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
7M0A29CD8B
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NELIPEPIMUT-S
USAN  
USAN  
Official Name English
HUMAN RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 (PROTO-ONCOGENE NEU, TYROSINE KINASE-TYPE CELL SURFACE RECEPTOR HER2, CD340)-(347-355)-PEPTIDE
Common Name English
E75 PEPTIDE
Code English
NELIPEPIMUT S
WHO-DD  
Common Name English
NELIPEPIMUT S [WHO-DD]
Common Name English
NEUVAX
Brand Name English
HER2 369-377
Common Name English
L-LEUCINE, L-LYSYL-L-ISOLEUCYL-L-PHENYLALANYLGLYCYL-L-SERYL-L-LEUCYL-L-ALANYL-L-PHENYLALANYL-
Common Name English
E-75 PEPTIDE
Code English
NELIPEPIMUT-S [USAN]
Common Name English
HER-2/NEU PEPTIDE (369-377)
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C129826
Created by admin on Sat Jun 26 16:29:48 UTC 2021 , Edited by admin on Sat Jun 26 16:29:48 UTC 2021
NCI_THESAURUS C1663
Created by admin on Sat Jun 26 16:29:48 UTC 2021 , Edited by admin on Sat Jun 26 16:29:48 UTC 2021
Code System Code Type Description
NCI_THESAURUS
C117985
Created by admin on Sat Jun 26 16:29:48 UTC 2021 , Edited by admin on Sat Jun 26 16:29:48 UTC 2021
PRIMARY
CAS
160212-35-1
Created by admin on Sat Jun 26 16:29:48 UTC 2021 , Edited by admin on Sat Jun 26 16:29:48 UTC 2021
PRIMARY
EVMPD
SUB185225
Created by admin on Sat Jun 26 16:29:48 UTC 2021 , Edited by admin on Sat Jun 26 16:29:48 UTC 2021
PRIMARY
PUBCHEM
9941306
Created by admin on Sat Jun 26 16:29:48 UTC 2021 , Edited by admin on Sat Jun 26 16:29:48 UTC 2021
PRIMARY
EPA CompTox
160212-35-1
Created by admin on Sat Jun 26 16:29:48 UTC 2021 , Edited by admin on Sat Jun 26 16:29:48 UTC 2021
PRIMARY
FDA UNII
7M0A29CD8B
Created by admin on Sat Jun 26 16:29:48 UTC 2021 , Edited by admin on Sat Jun 26 16:29:48 UTC 2021
PRIMARY
ChEMBL
CHEMBL2108684
Created by admin on Sat Jun 26 16:29:48 UTC 2021 , Edited by admin on Sat Jun 26 16:29:48 UTC 2021
PRIMARY
DRUG BANK
DB06226
Created by admin on Sat Jun 26 16:29:48 UTC 2021 , Edited by admin on Sat Jun 26 16:29:48 UTC 2021
PRIMARY
Related Record Type Details
TARGET->ANTIGEN
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL