U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Approval Year

Substance Class Protein
Created
by admin
on Wed Apr 02 00:05:24 GMT 2025
Edited
by admin
on Wed Apr 02 00:05:24 GMT 2025
Protein Type BISPECIFIC ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
HKH2GV9PVO
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ZANIDATAMAB ZOVODOTIN
INN  
Official Name English
IMMUNOGLOBULIN G1, ANTI-(HUMAN TYROSINE KINASE RECEPTOR HER2) (HUMAN-MUS MUSCULUS BIPARATOPIC MONOCLONAL ZW25 LIGHT CHAIN VARIABLE REGION FRAGMENT) FUSION PROTEIN WITH PEPTIDE (SYNTHETIC 20-AMINO ACID LINKER) FUSION PROTEIN WITH HUMAN-MUS MUSCULUS BIPARA
Preferred Name English
zanidatamab zovodotin [INN]
Common Name English
IMMUNOGLOBULIN HALF-IG G1-KAPPA/SCFV-H-CH2-CH3, ANTI-(HOMO SAPIENS ERBB2 (EPIDERMAL GROWTH FACTOR RECEPTOR 2, RECEPTOR TYROSINE PROTEIN KINASE ERBB-2, EGFR2, HER2, HER-2, P185C-ERBB2, NEU, CD340)), HUMANIZED MONOCLONAL ANTIBODY, BIPARATOPIC (TARGETING TW
Common Name English
ZW 49 [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C28227
Created by admin on Wed Apr 02 00:05:24 GMT 2025 , Edited by admin on Wed Apr 02 00:05:24 GMT 2025
FDA ORPHAN DRUG 522616
Created by admin on Wed Apr 02 00:05:24 GMT 2025 , Edited by admin on Wed Apr 02 00:05:24 GMT 2025
NCI_THESAURUS C155711
Created by admin on Wed Apr 02 00:05:24 GMT 2025 , Edited by admin on Wed Apr 02 00:05:24 GMT 2025
Code System Code Type Description
NCI_THESAURUS
C175879
Created by admin on Wed Apr 02 00:05:24 GMT 2025 , Edited by admin on Wed Apr 02 00:05:24 GMT 2025
PRIMARY
FDA UNII
HKH2GV9PVO
Created by admin on Wed Apr 02 00:05:24 GMT 2025 , Edited by admin on Wed Apr 02 00:05:24 GMT 2025
PRIMARY
SMS_ID
300000032569
Created by admin on Wed Apr 02 00:05:24 GMT 2025 , Edited by admin on Wed Apr 02 00:05:24 GMT 2025
PRIMARY
INN
11433
Created by admin on Wed Apr 02 00:05:24 GMT 2025 , Edited by admin on Wed Apr 02 00:05:24 GMT 2025
PRIMARY
DRUG BANK
DB15472
Created by admin on Wed Apr 02 00:05:24 GMT 2025 , Edited by admin on Wed Apr 02 00:05:24 GMT 2025
PRIMARY
CAS
2329698-82-8
Created by admin on Wed Apr 02 00:05:24 GMT 2025 , Edited by admin on Wed Apr 02 00:05:24 GMT 2025
PRIMARY
From To
1_24 1_89
1_150 1_224
1_261 2_229
1_264 2_232
1_296 1_356
1_402 1_460
2_23 2_97
2_147 2_203
2_223 3_215
2_264 2_324
2_370 2_428
3_24 3_89
3_135 3_195
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_332
N 2_300
Related Record Type Details
TARGET->CONJUGATED TOXIN
PARENT -> CONJUGATE
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
LIGAND_BINDING RESIDUE_SPECIFIC CYSTEIN Amount: Cysteinyl zovodotin JQR5LQL7EM
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL