CINREBAFUSP ALFA

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Sat Jun 26 18:11:29 UTC 2021` Edited by `admin` on `Sat Jun 26 18:11:29 UTC 2021`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	21Z359Z1CV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CINREBAFUSP ALFA

Official Name

English

PRS-343

Preferred Name

English

IMMUNOGLOBULIN G4 (228-PROLINE, 234-ALANINE, 235-ALANINE), ANTI-(HUMAN TYROSINE KINASE RECEPTOR HER2) (HUMAN-MUS MUSCULUS MONOCLONAL PRS-343 .GAMMA.4-CHAIN) FUSION PROTEIN PEPTIDE (SYNTHETIC 15-AMINO ACID LINKER) FUSION PROTEIN WITH LIPOCALIN 2 (HUMAN MU

Common Name

English

FUS: MAB HUMANIZED (IGG4) S228P, F234A, L235A ANTI P04626 (ERBB2_HUMAN)RPROT P80188 (NGAL_HUMAN) ANTI Q07011 (TNR9_HUMAN) (PRS343)

Common Name

English

(S228>P,F234>A,L235>A) IMMUNOGLOBULIN G4-KAPPA (CHIMERIC HUMAN-MUS MUSCULUS, ANTI-(RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2, ERBB2, HER2)) FUSED ON BOTH HEAVY CHAINS (1-447, 1''-447'') VIA A (G4S)3 LINKER (448-462, 448''-462'') TO A CD137 (TUMOR NECROSIS

Common Name

English

CINREBAFUSP ALFA [INN]

Common Name

English

CINREBAFUSP ALFA [USAN]

Common Name

English

PRS 343 [WHO-DD]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C142890

Created by admin on Sat Jun 26 18:11:29 UTC 2021 , Edited by admin on Sat Jun 26 18:11:29 UTC 2021

PRIMARY

FDA UNII

21Z359Z1CV

Created by admin on Sat Jun 26 18:11:29 UTC 2021 , Edited by admin on Sat Jun 26 18:11:29 UTC 2021

PRIMARY

INN

11094

Created by admin on Sat Jun 26 18:11:29 UTC 2021 , Edited by admin on Sat Jun 26 18:11:29 UTC 2021

PRIMARY

CAS

2218515-90-1

Created by admin on Sat Jun 26 18:11:29 UTC 2021 , Edited by admin on Sat Jun 26 18:11:29 UTC 2021

PRIMARY

From	To
1_22	1_96
1_134	3_214
1_147	1_203
1_226	2_226
1_229	2_229
1_261	1_321
1_367	1_425
1_538	1_637
2_22	2_96
2_134	4_214
2_147	2_203
2_261	2_321
2_367	2_425
2_538	2_637
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_297
N	2_297

Related Record Type Details


					7J9Y28299R

RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2

TARGET -> INHIBITOR


					7VWM3OLK0G

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 9

TARGET -> INHIBITOR

Related Record Type Details


					21Z359Z1CV

CINREBAFUSP ALFA

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL