PERTUZUMAB

Approval Year

Substance Class	Protein
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	K16AIQ8CTM
Record Status	`Validated (UNII)`
Record Version

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Related Record

Type

ALTERNATIVE DEFINITION for [PERTUZUMAB]

Alternative Definition

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Name

Type

Language

PERTUZUMAB

Official Name

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN NEU (RECEPTOR)) (HUMAN-MOUSE MONOCLONAL 2C4 HEAVY CHAIN), DISULFIDE WITH HUMAN-MOUSE MONOCLONAL 2C4 .KAPPA.-CHAIN, DIMER

Common Name

English

RHUMAB-2C4

Code

English

PERTUZUMAB [VANDF]

Common Name

English

PERTUZUMAB [JAN]

Common Name

English

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Classification Tree

Code System

Code

Designated

FDA ORPHAN DRUG

284409

Monoclonal antibodies

WHO-VATC

QL01XC13

Monoclonal Antibody

NCI_THESAURUS

C155711

Monoclonal antibodies

WHO-ATC

L01XC13

Established Pharmacologic Class

NDF-RT

N0000175661

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Code System

Code

Type

Description

INN

8380

PRIMARY

LACTMED

Pertuzumab

PRIMARY

DRUG CENTRAL

4957

PRIMARY

JAPANESE REVIEW

PERJETA

PRIMARY

APPROVED JUNE 2013

SMS_ID

100000078567

PRIMARY

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From	To
1_22	1_96
1_146	1_202
1_222	3_214
1_228	2_228
1_231	2_231

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Related Record

Type

Details


					7J9Y28299R

RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2

TARGET -> INHIBITOR

Comments:

HER dimerization inhibitor

Interaction Type:

BINDING

Amount:

PERTUZUMAB-ZZXF

SUB_CONCEPT->SUBSTANCE

Amount:


					H4LR6V1LWG

PERTUZUMAB ZUVOTOLIMOD

DERIVATIVE -> PARENT

Amount:


					KR4D9O3XRG

PERTUZUMAB DEFEROXAMINE ZIRCONIUM ZR-89

LABELED -> NON-LABELED

Amount:


					PQX0D8J21J

CETUXIMAB

INHIBITOR -> TARGET

Amount:

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Related Record

Type

Details


					K16AIQ8CTM

PERTUZUMAB

ACTIVE MOIETY

Amount:

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Name	Property Type	Amount
MOL_WEIGHT:SEQUENCE(CALCULATED)	CHEMICAL	SEQUENCE 145420.54 DA (average)
Volume of Distribution	PHARMACOKINETIC	0.07 Liters/Kilogram (average)

Molecular Formula	CHEMICAL	ESTIMATED C6476H9954N1710O2016S44
Biological Half-life	PHARMACOKINETIC	18 days (average)