MANGANOUS CATION

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	Mn
Molecular Weight	54.938
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	2

SHOW SMILES / InChI

Structure Search

SMILES

[Mn++]

InChI

InChIKey=WAEMQWOKJMHJLA-UHFFFAOYSA-N

InChI=1S/Mn/q+2

HIDE SMILES / InChI

Description
Sources: https://www.alfa.com/en/catalog/032808/https://www.ncbi.nlm.nih.gov/pubmed/6658791https://www.ncbi.nlm.nih.gov/pubmed/3725729 | https://www.ncbi.nlm.nih.gov/pubmed/3989083 | https://www.ncbi.nlm.nih.gov/pubmed/25464291 | https://www.ncbi.nlm.nih.gov/pubmed/20934746https://google.com/patents/CN104529454A?http://pubs.acs.org/doi/pdfplus/10.1021/jo970656jhttps://www.drugs.com/pro/manganese-sulfate-injection.htmlhttp://www.druginfosys.com/drug.aspx?drugcode=2295&type=1https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=184 | https://www.ncbi.nlm.nih.gov/pubmed/24861367
Curator's Comment: description was created based on several sources, including https://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/SCOGS/ucm260883.htm

Manganese citrate is generally recognized as safe direct food additive. Manganese citrate complex has being used in the determination of liver enzyme activities in the aging process and following treatment with aminoethylisothiuronium bromide hydrobromide (AET).

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Arginase-1 25 Target ID: CHEMBL1075097 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19032027	Activator 1430
Arginase-2, mitochondrial 24 Target ID: CHEMBL1795148 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25974698	Activator 1430
Glutamine synthetase 29 Target ID: CHEMBL4612 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25974698	Activator 1430

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2578
Unknown 2578
Unknown 2578
Cancer 592 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20934746	Primary	Basic research	Unknown Approved Use Unknown
Manganese deficiency 27 Sources: http://www.webmd.com/vitamins-supplements/ingredientmono-182-manganese.aspx?activeingredientid=182&	Primary	Approved 8429	Unknown Approved Use Manganese is used for prevention and treatment of manganese deficiency, a condition in which the body doesn’t have enough manganese.
Osteoporosis 97 Sources: http://www.webmd.com/vitamins-supplements/ingredientmono-182-manganese.aspx?activeingredientid=182&	Primary	Approved 8429	Unknown Approved Use Manganese is used for weak bones (osteoporosis).
Premenstrual syndrome 37 Sources: http://www.webmd.com/vitamins-supplements/ingredientmono-182-manganese.aspx?activeingredientid=182&	Palliative	Approved 8429	Unknown Approved Use Early research suggests that taking manganese along with calcium helps improve symptoms of PMS, including pain, crying, loneliness, anxiety, restlessness, irritability, mood swings, depression, and tension.
Manganese deficiency 27 Sources: https://www.drugs.com/pro/manganese-sulfate-injection.html	Curative	Approved 8429	MANGANESE SULFATE Approved Use Manganese Sulfate Injection, USP is indicated for use as a supplement to intravenous solutions given for Total Parenteral Nutrition (TPN). Administration helps to maintain plasma levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
Unknown 2578
Unknown 2578
Gastrointestinal disorders 95 Sources: https://www.drugs.com/cdi/magnesium-sulfate.html	Primary	Approved 8429	MANGANESE SULFATE Approved Use Unknown

PubMed

Title	Date	PubMed
Cytochrome oxidase determination using a manganese citrate complex.	1970	4322423
Dietary calcium and manganese effects on menstrual cycle symptoms.	1993 May	8498421
Manganese citrate chemistry: syntheses, spectroscopic studies, and structural characterizations of novel mononuclear, water-soluble manganese citrate complexes.	2000 Sep 4	11198859
Is the axial zero-field splitting parameter of tetragonally elongated high-spin manganese(III) complexes always negative?	2002 Jul 31	12137507
Manganese distribution across the blood-brain barrier. I. Evidence for carrier-mediated influx of managanese citrate as well as manganese and manganese transferrin.	2003 Jan	12564377
Bi- and poly-metallic cyanide-bridged complexes of the redox-active cyanomanganese nitrosyl unit [Mn(CN)(PR3)(NO)(eta-C5H4Me)].	2004 Feb 21	15252534
Manganese potentiates in vitro production of proinflammatory cytokines and nitric oxide by microglia through a nuclear factor kappa B-dependent mechanism.	2005 Mar	15601679
Persistent alterations in biomarkers of oxidative stress resulting from combined in utero and neonatal manganese inhalation.	2005 May	15894815
CsR(R(6)CoI(12))2 (R = Gd, Er) and (CeI)0.26(Ce(6)MnI(9))2: two new structure types featuring R(6)Z clusters.	2006 Nov 27	17112265
Yolk-Shell MnO@ZnMn(2) O(4) /N-C Nanorods Derived from α-MnO(2) /ZIF-8 as Anode Materials for Lithium Ion Batteries.	2016 Oct	27562457
Intramolecular Aminoalkoxylation of Unfunctionalized Olefins via Intramolecular Iodoamination and Aziridinium Ion Ring-Opening Sequence.	2017 Apr 7	28333470

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Name

Type

Language

MANGANOUS CATION

Common Name

English

MANGANESE, ION (MN2+)

Common Name

English

MANGANESE(II) ION

Common Name

English

MANGANESE(II)

Systematic Name

English

MANGANESE CATION (MN2+)

Common Name

English

MANGANESE ION(2+)

Common Name

English

MANGANESE CATION (2+)

Common Name

English

MANGANESE DICATION

Common Name

English

MANGANESE(2+)

Systematic Name

English

Classification Tree Code System Code

NDF-RT

N0000180184