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Details

Stereochemistry ACHIRAL
Molecular Formula Mn
Molecular Weight 54.938
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 2

SHOW SMILES / InChI
Structure of MANGANESE CATION (2+)

SMILES

[Mn+2]

InChI

InChIKey=WAEMQWOKJMHJLA-UHFFFAOYSA-N
InChI=1S/Mn/q+2

HIDE SMILES / InChI
Manganese Bromide is a highly water soluble crystalline salt composed of manganese and bromine with the formula MnBr2. Manganese Bromide can be used in place of palladium in the Stille reaction, which couples two carbon atoms using an organotin compound

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Manganese is used for prevention and treatment of manganese deficiency, a condition in which the body doesn’t have enough manganese.
Primary
Unknown

Approved Use

Manganese is used for weak bones (osteoporosis).
Palliative
Unknown

Approved Use

Early research suggests that taking manganese along with calcium helps improve symptoms of PMS, including pain, crying, loneliness, anxiety, restlessness, irritability, mood swings, depression, and tension.
Curative
MANGANESE SULFATE

Approved Use

Manganese Sulfate Injection, USP is indicated for use as a supplement to intravenous solutions given for Total Parenteral Nutrition (TPN). Administration helps to maintain plasma levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
Primary
MANGANESE SULFATE

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Cytochrome oxidase determination using a manganese citrate complex.
1970
Effect of fluoride on copper, manganese and zinc in bone and kidney.
1981 Mar
Transformation of BALB/c-3T3 cells: IV. Rank-ordered potency of 24 chemical responses detected in a sensitive new assay procedure.
1993 Jul
Manganese citrate chemistry: syntheses, spectroscopic studies, and structural characterizations of novel mononuclear, water-soluble manganese citrate complexes.
2000 Sep 4
Differential ability of transition metals to induce pulmonary inflammation.
2001 Nov 15
Tetraaqua(1,10-phenanthroline-kappa(2)N,N')manganese(II) sulfate dihydrate.
2002 Jul
Is the axial zero-field splitting parameter of tetragonally elongated high-spin manganese(III) complexes always negative?
2002 Jul 31
Glutamate/aspartate transporter (GLAST), taurine transporter and metallothionein mRNA levels are differentially altered in astrocytes exposed to manganese chloride, manganese phosphate or manganese sulfate.
2002 Sep
Bi- and poly-metallic cyanide-bridged complexes of the redox-active cyanomanganese nitrosyl unit [Mn(CN)(PR3)(NO)(eta-C5H4Me)].
2004 Feb 21
Persistent alterations in biomarkers of oxidative stress resulting from combined in utero and neonatal manganese inhalation.
2005 May
Decreased expression of inflammation-related genes following inhalation exposure to manganese.
2006 May
CsR(R(6)CoI(12))2 (R = Gd, Er) and (CeI)0.26(Ce(6)MnI(9))2: two new structure types featuring R(6)Z clusters.
2006 Nov 27
Alterations of oxidative stress biomarkers due to in utero and neonatal exposures of airborne manganese.
2006 Summer
Effects of chronic manganese exposure on glutamatergic and GABAergic neurotransmitter markers in the nonhuman primate brain.
2009 Sep
Expression profile analysis of antioxidative stress and developmental pathway genes in the manganese-exposed intertidal copepod Tigriopus japonicus with 6K oligochip.
2013 Aug
Controlled Synthesis of Hollow Manganese Oxide Nanocrystals.
2016 Feb
Chronic exposure to manganese sulfate leads to adverse dose-dependent effects on the neurobehavioral ability of rats.
2016 Nov
Intramolecular Aminoalkoxylation of Unfunctionalized Olefins via Intramolecular Iodoamination and Aziridinium Ion Ring-Opening Sequence.
2017 Apr 7
Patents

Sample Use Guides

Pigs: 3.5 g. of manganese citrate daily has been fed to pigs for 9 months
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment:: In vitro cytotoxicity of manganese oxide (MnO) using live/dead cell assay, lactate dehydrogenase assay, and reactive oxygen species detection with variation of the concentration of nanoparticles (5-500 ug/ml), incubation time (18-96 h), and different human cell lines (lung adenocarcinoma, breast cancer cells, and glioblastoma cells) was studied. The cytotoxic effect was negligible for 18 h incubation even at highest concentration of 500 ug/ml MnO nanoparticle.
Unknown
Name Type Language
MANGANESE CATION (2+)
Common Name English
MANGANESE, ION (MN2+)
Common Name English
MANGANESE(II) ION
Common Name English
MANGANESE CATION (MN2+)
Common Name English
MANGANESE ION(2+)
Common Name English
Classification Tree Code System Code
NDF-RT N0000180184
Created by admin on Sat Jun 26 01:08:57 UTC 2021 , Edited by admin on Sat Jun 26 01:08:57 UTC 2021
NDF-RT N0000175862
Created by admin on Sat Jun 26 01:08:57 UTC 2021 , Edited by admin on Sat Jun 26 01:08:57 UTC 2021
Code System Code Type Description
EPA CompTox
16397-91-4
Created by admin on Sat Jun 26 01:08:57 UTC 2021 , Edited by admin on Sat Jun 26 01:08:57 UTC 2021
PRIMARY
RXCUI
1546272
Created by admin on Sat Jun 26 01:08:57 UTC 2021 , Edited by admin on Sat Jun 26 01:08:57 UTC 2021
PRIMARY RxNorm
NCI_THESAURUS
C68267
Created by admin on Sat Jun 26 01:08:57 UTC 2021 , Edited by admin on Sat Jun 26 01:08:57 UTC 2021
PRIMARY
FDA UNII
H6EP7W5457
Created by admin on Sat Jun 26 01:08:57 UTC 2021 , Edited by admin on Sat Jun 26 01:08:57 UTC 2021
PRIMARY
CAS
16397-91-4
Created by admin on Sat Jun 26 01:08:57 UTC 2021 , Edited by admin on Sat Jun 26 01:08:57 UTC 2021
PRIMARY
PUBCHEM
27854
Created by admin on Sat Jun 26 01:08:57 UTC 2021 , Edited by admin on Sat Jun 26 01:08:57 UTC 2021
PRIMARY