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Details

Stereochemistry ABSOLUTE
Molecular Formula C21H35N5.2Cl.Mn
Molecular Weight 483.38
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IMISOPASEM MANGANESE

SMILES

[Cl-].[Cl-].[Mn++].C1CC[C@H]2NCC3=CC=CC(CN[C@@H]4CCCC[C@H]4NCCN[C@@H]2C1)=N3

InChI

InChIKey=WXEMWBBXVXHEPU-XNPJUPKFSA-L
InChI=1S/C21H35N5.2ClH.Mn/c1-3-10-20-18(8-1)22-12-13-23-19-9-2-4-11-21(19)25-15-17-7-5-6-16(26-17)14-24-20;;;/h5-7,18-25H,1-4,8-15H2;2*1H;/q;;;+2/p-2/t18-,19-,20-,21-;;;/m1.../s1

HIDE SMILES / InChI

Molecular Formula C21H35N5
Molecular Weight 357.5361
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula Mn
Molecular Weight 54.938
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Imisopasem Manganese is a manganese-based non-peptidyl mimetic of the human mitochondrial manganese superoxide dismutase (MnSOD), with potential antioxidant and radioprotective activities. Metaphore Pharmaceuticals Inc. is developing Imisopasem Manganese for the potential treatment of pain, dermatological disease and inflammation. Upon administration, imisopasem manganese mimics the activity of MnSOD and scavenges reactive oxygen species (ROS), such as superoxide anion, which prevents oxygen free radical damage to macromolecules such as DNA. This reduces ROS-mediated lipid peroxidation, prevents apoptosis and protects against oxygen free radical-induced toxicity in normal tissues.

Approval Year

PubMed

PubMed

TitleDatePubMed
Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic, M40403.
2001 Feb
Superoxide dismutase mimetic M40403 improves endothelial function in apolipoprotein(E)-deficient mice.
2003 Jul
Patents

Patents

Sample Use Guides

single doses of 0.0625, 0.125, and 0.25 mg/kg
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:51:08 UTC 2023
Edited
by admin
on Sat Dec 16 17:51:08 UTC 2023
Record UNII
2Q6R3259KS
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
IMISOPASEM MANGANESE
INN   MI   USAN   WHO-DD  
INN   USAN  
Official Name English
IMISOPASEM MANGANESE [MI]
Common Name English
SC-72325
Code English
Imisopasem manganese [WHO-DD]
Common Name English
M40403
Code English
IMISOPASEM MANGANESE [USAN]
Common Name English
M-40403
Code English
imisopasem manganese [INN]
Common Name English
IMISOPASEM MANGANESE DICHLORIDE
Common Name English
GC-4403
Code English
Classification Tree Code System Code
NCI_THESAURUS C275
Created by admin on Sat Dec 16 17:51:09 UTC 2023 , Edited by admin on Sat Dec 16 17:51:09 UTC 2023
Code System Code Type Description
DRUG BANK
DB04976
Created by admin on Sat Dec 16 17:51:09 UTC 2023 , Edited by admin on Sat Dec 16 17:51:09 UTC 2023
PRIMARY
NCI_THESAURUS
C111684
Created by admin on Sat Dec 16 17:51:09 UTC 2023 , Edited by admin on Sat Dec 16 17:51:09 UTC 2023
PRIMARY
MESH
C121876
Created by admin on Sat Dec 16 17:51:09 UTC 2023 , Edited by admin on Sat Dec 16 17:51:09 UTC 2023
PRIMARY
INN
8634
Created by admin on Sat Dec 16 17:51:09 UTC 2023 , Edited by admin on Sat Dec 16 17:51:09 UTC 2023
PRIMARY
EVMPD
SUB190201
Created by admin on Sat Dec 16 17:51:09 UTC 2023 , Edited by admin on Sat Dec 16 17:51:09 UTC 2023
PRIMARY
FDA UNII
2Q6R3259KS
Created by admin on Sat Dec 16 17:51:09 UTC 2023 , Edited by admin on Sat Dec 16 17:51:09 UTC 2023
PRIMARY
PUBCHEM
6918487
Created by admin on Sat Dec 16 17:51:09 UTC 2023 , Edited by admin on Sat Dec 16 17:51:09 UTC 2023
PRIMARY
SMS_ID
100000175707
Created by admin on Sat Dec 16 17:51:09 UTC 2023 , Edited by admin on Sat Dec 16 17:51:09 UTC 2023
PRIMARY
MERCK INDEX
m6235
Created by admin on Sat Dec 16 17:51:09 UTC 2023 , Edited by admin on Sat Dec 16 17:51:09 UTC 2023
PRIMARY Merck Index
CAS
218791-21-0
Created by admin on Sat Dec 16 17:51:09 UTC 2023 , Edited by admin on Sat Dec 16 17:51:09 UTC 2023
PRIMARY
EPA CompTox
DTXSID20944477
Created by admin on Sat Dec 16 17:51:09 UTC 2023 , Edited by admin on Sat Dec 16 17:51:09 UTC 2023
PRIMARY
USAN
QQ-97
Created by admin on Sat Dec 16 17:51:09 UTC 2023 , Edited by admin on Sat Dec 16 17:51:09 UTC 2023
PRIMARY
ChEMBL
CHEMBL3544979
Created by admin on Sat Dec 16 17:51:09 UTC 2023 , Edited by admin on Sat Dec 16 17:51:09 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE
TARGET->MIMETIC