IMISOPASEM MANGANESE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H35N5.2Cl.Mn
Molecular Weight	483.38
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Cl-].[Cl-].[Mn++].C1CC[C@H]2NCC3=CC=CC(CN[C@@H]4CCCC[C@H]4NCCN[C@@H]2C1)=N3

InChI

InChIKey=WXEMWBBXVXHEPU-XNPJUPKFSA-L

InChI=1S/C21H35N5.2ClH.Mn/c1-3-10-20-18(8-1)22-12-13-23-19-9-2-4-11-21(19)25-15-17-7-5-6-16(26-17)14-24-20;;;/h5-7,18-25H,1-4,8-15H2;2*1H;/q;;;+2/p-2/t18-,19-,20-,21-;;;/m1.../s1

HIDE SMILES / InChI

Molecular Formula	C21H35N5
Molecular Weight	357.5361
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	Mn
Molecular Weight	54.938
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15650944 | https://www.ncbi.nlm.nih.gov/pubmed/12406666

Imisopasem Manganese is a manganese-based non-peptidyl mimetic of the human mitochondrial manganese superoxide dismutase (MnSOD), with potential antioxidant and radioprotective activities. Metaphore Pharmaceuticals Inc. is developing Imisopasem Manganese for the potential treatment of pain, dermatological disease and inflammation. Upon administration, imisopasem manganese mimics the activity of MnSOD and scavenges reactive oxygen species (ROS), such as superoxide anion, which prevents oxygen free radical damage to macromolecules such as DNA. This reduces ROS-mediated lipid peroxidation, prevents apoptosis and protects against oxygen free radical-induced toxicity in normal tissues.

Originator

Approval Year

PubMed

Title	Date	PubMed
Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic, M40403.	2001 Feb	11181422
A role for superoxide in gentamicin-mediated nephropathy in rats.	2002 Aug 16	12176111
Superoxide dismutase mimetic M40403 improves endothelial function in apolipoprotein(E)-deficient mice.	2003 Jul	12871831

Patents

Sample Use Guides

In Vivo Use Guide

single doses of 0.0625, 0.125, and 0.25 mg/kg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:51:08 GMT 2023` Edited by `admin` on `Sat Dec 16 17:51:08 GMT 2023`
Record UNII	2Q6R3259KS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IMISOPASEM MANGANESE

Official Name

English

IMISOPASEM MANGANESE [MI]

Common Name

English

SC-72325

Code

English

Imisopasem manganese [WHO-DD]

Common Name

English

M40403

Code

English

IMISOPASEM MANGANESE [USAN]

Common Name

English

M-40403

Code

English

imisopasem manganese [INN]

Common Name

English

IMISOPASEM MANGANESE DICHLORIDE

Common Name

English

GC-4403

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C275