Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C4H6N2S4.Mn |
| Molecular Weight | 265.302 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Mn++].[S-]C(=S)NCCNC([S-])=S
InChI
InChIKey=YKSNLCVSTHTHJA-UHFFFAOYSA-L
InChI=1S/C4H8N2S4.Mn/c7-3(8)5-1-2-6-4(9)10;/h1-2H2,(H2,5,7,8)(H2,6,9,10);/q;+2/p-2
| Molecular Formula | Mn |
| Molecular Weight | 54.938 |
| Charge | 2 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C4H8N2S4 |
| Molecular Weight | 212.38 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Studies of teratogenic effects of the dithiocarbamates maneb, mancozeb, and propineb. | 1976 Oct |
|
| Dithiocarbamate fungicides decrease histochemical reactivity of cholinesterases in the gut wall of the rat. | 1985 |
|
| [Contact eczema caused by pesticides in East Germany]. | 1989 |
|
| Acute exposure to maneb alters some behavioral functions in the mouse. | 1989 Sep-Oct |
|
| Occupational allergic contact dermatitis and airborne contact dermatitis from 5 fungicides in a vineyard worker. Cross-reactions between fungicides of the dithiocarbamate group? | 1996 May |
|
| The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease. | 2000 Dec 15 |
|
| Genotoxic and mono-oxygenase system effects of the fungicide maneb. | 2000 Sep |
|
| Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype. | 2003 Aug |
|
| Proteasomal inhibition induced by manganese ethylene-bis-dithiocarbamate: relevance to Parkinson's disease. | 2004 |
|
| Pesticide use and menstrual cycle characteristics among premenopausal women in the Agricultural Health Study. | 2004 Dec 15 |
|
| Modulation of antioxidant defense systems by the environmental pesticide maneb in dopaminergic cells. | 2005 Jan |
|
| Retinal degeneration and other eye disorders in wives of farmer pesticide applicators enrolled in the agricultural health study. | 2005 Jun 1 |
|
| [WITHDRAWN] Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype. | 2005 Jun 10 |
|
| Early environmental origins of neurodegenerative disease in later life. | 2005 Sep |
|
| Chemical stress sensitive luminescent human cells: molecular biology approach using inducible Drosophila melanogaster hsp22 promoter. | 2005 Sep 23 |
|
| Status of antioxidant defense system and expression of toxicant responsive genes in striatum of maneb- and paraquat-induced Parkinson's disease phenotype in mouse: mechanism of neurodegeneration. | 2006 Apr 7 |
|
| Temporal effects of paraquat/maneb on microglial activation and dopamine neuronal loss in older rats. | 2006 Aug |
|
| Inhibition of aldehyde detoxification in CNS mitochondria by fungicides. | 2007 Jan |
|
| Identification of differentially expressed proteins in striatum of maneb-and paraquat-induced Parkinson's disease phenotype in mouse. | 2007 Sep-Oct |
|
| Gene expression profiles of mouse striatum in control and maneb + paraquat-induced Parkinson's disease phenotype: validation of differentially expressed energy metabolizing transcripts. | 2008 Sep |
|
| Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California. | 2009 Apr 15 |
|
| Dopamine transporter genetic variants and pesticides in Parkinson's disease. | 2009 Jun |
|
| Involvement of nitric oxide in maneb- and paraquat-induced Parkinson's disease phenotype in mouse: is there any link with lipid peroxidation? | 2010 Aug |
|
| Maneb and paraquat-induced modulation of toxicant responsive genes in the rat liver: comparison with polymorphonuclear leukocytes. | 2010 Dec 5 |
|
| Pesticide use and thyroid disease among women in the Agricultural Health Study. | 2010 Feb 15 |
|
| Gender-linked haematopoietic and metabolic disturbances induced by a pesticide mixture administered at low dose to mice. | 2010 Jan 12 |
|
| Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural heath study. | 2010 Jun |
|
| Parkinson's disease risk from ambient exposure to pesticides. | 2011 Jul |
|
| Maneb and paraquat-mediated neurotoxicity: involvement of peroxiredoxin/thioredoxin system. | 2011 Jun |
|
| Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse. | 2011 Mar |
|
| Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets. | 2011 Mar 28 |
|
| Environmental impact on vascular development predicted by high-throughput screening. | 2011 Nov |
|
| Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease. | 2012 |
|
| Paraquat, but not maneb, induces synucleinopathy and tauopathy in striata of mice through inhibition of proteasomal and autophagic pathways. | 2012 |
|
| Resveratrol potentiates cytochrome P450 2 d22-mediated neuroprotection in maneb- and paraquat-induced parkinsonism in the mouse. | 2012 Apr 15 |
|
| Species-specific differences in the inhibition of human and zebrafish 11β-hydroxysteroid dehydrogenase 2 by thiram and organotins. | 2012 Nov 15 |
|
| Ethylene bisdithiocarbamate pesticides cause cytotoxicity in transformed and normal human colon cells. | 2012 Sep |
|
| Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease. | 2012 Sep 28 |
|
| Minocycline, levodopa and MnTMPyP induced changes in the mitochondrial proteome profile of MPTP and maneb and paraquat mice models of Parkinson's disease. | 2013 Aug |
|
| S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease. | 2013 Aug 28 |
|
| Silymarin- and melatonin-mediated changes in the expression of selected genes in pesticides-induced Parkinsonism. | 2013 Dec |
|
| Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription. | 2013 Dec 5 |
|
| Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb- and paraquat-induced hepatotoxicity in rats. | 2013 Jan 25 |
|
| Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays. | 2013 Jun 17 |
|
| Maneb causes pro-oxidant effects in the hippocampus of Nrf2 knockout mice. | 2013 Sep |
|
| Immunohistochemical and histopathological changes in the skin of rats after maneb application. | 2014 Dec |
|
| RTP801 regulates maneb- and mancozeb-induced cytotoxicity via NF-κB. | 2014 Jul |
|
| Consequences of developmental exposure to concentrated ambient ultrafine particle air pollution combined with the adult paraquat and maneb model of the Parkinson's disease phenotype in male mice. | 2014 Mar |
|
| Ziram and sodium N,N-dimethyldithiocarbamate inhibit ubiquitin activation through intracellular metal transport and increased oxidative stress in HEK293 cells. | 2015 Apr 20 |
|
| Combined exposure to agriculture pesticides, paraquat and maneb, induces alterations in the N/OFQ-NOPr and PDYN/KOPr systems in rats: Relevance to sporadic Parkinson's disease. | 2015 May-Jun |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:33:43 GMT 2023
by
admin
on
Sat Dec 16 05:33:43 GMT 2023
|
| Record UNII |
K221E12G7T
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
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| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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EPA PESTICIDE CODE |
14505
Created by
admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
301-03-1
Created by
admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
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ALTERNATIVE | |||
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MANEB
Created by
admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
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PRIMARY | |||
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3032581
Created by
admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
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PRIMARY | |||
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m7056
Created by
admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
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PRIMARY | Merck Index | ||
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12427-38-2
Created by
admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
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PRIMARY | |||
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maneb
Created by
admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
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PRIMARY | |||
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K221E12G7T
Created by
admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
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PRIMARY | |||
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D008344
Created by
admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
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PRIMARY | |||
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235-654-8
Created by
admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
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PRIMARY | |||
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4063
Created by
admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE | |||
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PARENT -> SALT/SOLVATE |
