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Details

Stereochemistry ACHIRAL
Molecular Formula C4H6N2S4.Mn
Molecular Weight 265.302
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MANEB

SMILES

[Mn++].[S-]C(=S)NCCNC([S-])=S

InChI

InChIKey=YKSNLCVSTHTHJA-UHFFFAOYSA-L
InChI=1S/C4H8N2S4.Mn/c7-3(8)5-1-2-6-4(9)10;/h1-2H2,(H2,5,7,8)(H2,6,9,10);/q;+2/p-2

HIDE SMILES / InChI

Molecular Formula Mn
Molecular Weight 54.938
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C4H8N2S4
Molecular Weight 212.38
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Studies of teratogenic effects of the dithiocarbamates maneb, mancozeb, and propineb.
1976 Oct
Dithiocarbamate fungicides decrease histochemical reactivity of cholinesterases in the gut wall of the rat.
1985
[Contact eczema caused by pesticides in East Germany].
1989
Acute exposure to maneb alters some behavioral functions in the mouse.
1989 Sep-Oct
Occupational allergic contact dermatitis and airborne contact dermatitis from 5 fungicides in a vineyard worker. Cross-reactions between fungicides of the dithiocarbamate group?
1996 May
The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease.
2000 Dec 15
Genotoxic and mono-oxygenase system effects of the fungicide maneb.
2000 Sep
Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype.
2003 Aug
Proteasomal inhibition induced by manganese ethylene-bis-dithiocarbamate: relevance to Parkinson's disease.
2004
Pesticide use and menstrual cycle characteristics among premenopausal women in the Agricultural Health Study.
2004 Dec 15
Modulation of antioxidant defense systems by the environmental pesticide maneb in dopaminergic cells.
2005 Jan
Retinal degeneration and other eye disorders in wives of farmer pesticide applicators enrolled in the agricultural health study.
2005 Jun 1
[WITHDRAWN] Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype.
2005 Jun 10
Early environmental origins of neurodegenerative disease in later life.
2005 Sep
Chemical stress sensitive luminescent human cells: molecular biology approach using inducible Drosophila melanogaster hsp22 promoter.
2005 Sep 23
Status of antioxidant defense system and expression of toxicant responsive genes in striatum of maneb- and paraquat-induced Parkinson's disease phenotype in mouse: mechanism of neurodegeneration.
2006 Apr 7
Temporal effects of paraquat/maneb on microglial activation and dopamine neuronal loss in older rats.
2006 Aug
Inhibition of aldehyde detoxification in CNS mitochondria by fungicides.
2007 Jan
Identification of differentially expressed proteins in striatum of maneb-and paraquat-induced Parkinson's disease phenotype in mouse.
2007 Sep-Oct
Gene expression profiles of mouse striatum in control and maneb + paraquat-induced Parkinson's disease phenotype: validation of differentially expressed energy metabolizing transcripts.
2008 Sep
Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California.
2009 Apr 15
Dopamine transporter genetic variants and pesticides in Parkinson's disease.
2009 Jun
Involvement of nitric oxide in maneb- and paraquat-induced Parkinson's disease phenotype in mouse: is there any link with lipid peroxidation?
2010 Aug
Maneb and paraquat-induced modulation of toxicant responsive genes in the rat liver: comparison with polymorphonuclear leukocytes.
2010 Dec 5
Pesticide use and thyroid disease among women in the Agricultural Health Study.
2010 Feb 15
Gender-linked haematopoietic and metabolic disturbances induced by a pesticide mixture administered at low dose to mice.
2010 Jan 12
Pesticide use and cutaneous melanoma in pesticide applicators in the agricultural heath study.
2010 Jun
Parkinson's disease risk from ambient exposure to pesticides.
2011 Jul
Maneb and paraquat-mediated neurotoxicity: involvement of peroxiredoxin/thioredoxin system.
2011 Jun
Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse.
2011 Mar
Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets.
2011 Mar 28
Environmental impact on vascular development predicted by high-throughput screening.
2011 Nov
Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease.
2012
Paraquat, but not maneb, induces synucleinopathy and tauopathy in striata of mice through inhibition of proteasomal and autophagic pathways.
2012
Resveratrol potentiates cytochrome P450 2 d22-mediated neuroprotection in maneb- and paraquat-induced parkinsonism in the mouse.
2012 Apr 15
Species-specific differences in the inhibition of human and zebrafish 11β-hydroxysteroid dehydrogenase 2 by thiram and organotins.
2012 Nov 15
Ethylene bisdithiocarbamate pesticides cause cytotoxicity in transformed and normal human colon cells.
2012 Sep
Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease.
2012 Sep 28
Minocycline, levodopa and MnTMPyP induced changes in the mitochondrial proteome profile of MPTP and maneb and paraquat mice models of Parkinson's disease.
2013 Aug
S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease.
2013 Aug 28
Silymarin- and melatonin-mediated changes in the expression of selected genes in pesticides-induced Parkinsonism.
2013 Dec
Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.
2013 Dec 5
Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb- and paraquat-induced hepatotoxicity in rats.
2013 Jan 25
Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays.
2013 Jun 17
Maneb causes pro-oxidant effects in the hippocampus of Nrf2 knockout mice.
2013 Sep
Immunohistochemical and histopathological changes in the skin of rats after maneb application.
2014 Dec
RTP801 regulates maneb- and mancozeb-induced cytotoxicity via NF-κB.
2014 Jul
Consequences of developmental exposure to concentrated ambient ultrafine particle air pollution combined with the adult paraquat and maneb model of the Parkinson's disease phenotype in male mice.
2014 Mar
Ziram and sodium N,N-dimethyldithiocarbamate inhibit ubiquitin activation through intracellular metal transport and increased oxidative stress in HEK293 cells.
2015 Apr 20
Combined exposure to agriculture pesticides, paraquat and maneb, induces alterations in the N/OFQ-NOPr and PDYN/KOPr systems in rats: Relevance to sporadic Parkinson's disease.
2015 May-Jun
Substance Class Chemical
Created
by admin
on Sat Dec 16 05:33:43 GMT 2023
Edited
by admin
on Sat Dec 16 05:33:43 GMT 2023
Record UNII
K221E12G7T
Record Status Validated (UNII)
Record Version
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Name Type Language
MANEB
ISO   MI  
Common Name English
1,2-ETHYLENEDIYLBIS(CARBAMODITHIOATO)MANGANESE
Common Name English
ETHYLENEBIS(DITHIOCARBAMIC ACID) MANGANOUS SALT
Common Name English
MANEB 80
Common Name English
MANEBGAN
Common Name English
MANEB [IARC]
Common Name English
MANEB [ISO]
Common Name English
CARBAMODITHIOIC ACID, 1,2-ETHANEDIYLBIS-, MANGANESE COMPLEX
Common Name English
MANEB [MI]
Common Name English
MANGANESE, (N-(2-((DITHIOCARBOXY)AMINO)ETHYL)CARBAMODITHIOATO(2-)-.KAPPA.S,.KAPPA.S')-
Common Name English
MANGANESE, ((1,2-ETHANEDIYLBIS(CARBAMODITHIOATO))(2-))-
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 14505
Created by admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
Code System Code Type Description
CAS
301-03-1
Created by admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
ALTERNATIVE
WIKIPEDIA
MANEB
Created by admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
PRIMARY
PUBCHEM
3032581
Created by admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
PRIMARY
MERCK INDEX
m7056
Created by admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
PRIMARY Merck Index
CAS
12427-38-2
Created by admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
PRIMARY
ALANWOOD
maneb
Created by admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
PRIMARY
FDA UNII
K221E12G7T
Created by admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
PRIMARY
MESH
D008344
Created by admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
PRIMARY
ECHA (EC/EINECS)
235-654-8
Created by admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
PRIMARY
HSDB
4063
Created by admin on Sat Dec 16 05:33:43 GMT 2023 , Edited by admin on Sat Dec 16 05:33:43 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE