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Details

Stereochemistry ACHIRAL
Molecular Formula Mn.O4S.4H2O
Molecular Weight 223.062
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MANGANOUS SULFATE TETRAHYDRATE

SMILES

O.O.O.O.[Mn++].[O-]S([O-])(=O)=O

InChI

InChIKey=CDUFCUKTJFSWPL-UHFFFAOYSA-L
InChI=1S/Mn.H2O4S.4H2O/c;1-5(2,3)4;;;;/h;(H2,1,2,3,4);4*1H2/q+2;;;;;/p-2

HIDE SMILES / InChI

Molecular Formula O4S
Molecular Weight 96.063
Charge -2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Mn
Molecular Weight 54.938
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Manganese citrate is generally recognized as safe direct food additive. Manganese citrate complex has being used in the determination of liver enzyme activities in the aging process and following treatment with aminoethylisothiuronium bromide hydrobromide (AET).

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Manganese is used for prevention and treatment of manganese deficiency, a condition in which the body doesn’t have enough manganese.
Primary
Unknown

Approved Use

Manganese is used for weak bones (osteoporosis).
Palliative
Unknown

Approved Use

Early research suggests that taking manganese along with calcium helps improve symptoms of PMS, including pain, crying, loneliness, anxiety, restlessness, irritability, mood swings, depression, and tension.
Curative
MANGANESE SULFATE

Approved Use

Manganese Sulfate Injection, USP is indicated for use as a supplement to intravenous solutions given for Total Parenteral Nutrition (TPN). Administration helps to maintain plasma levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
Primary
MANGANESE SULFATE

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Cytochrome oxidase determination using a manganese citrate complex.
1970
Metabolism of l-Tyrosine to 4-Hydroxybenzaldehyde and 3-Bromo-4-Hydroxybenzaldehyde by Chloroplast-containing Fractions of Odonthalia floccosa (Esp.) Falk.
1979 Dec
Effect of fluoride on copper, manganese and zinc in bone and kidney.
1981 Mar
Manganese citrate improves base-calling accuracy in DNA sequencing reactions using rhodamine-based fluorescent dye-terminators.
1999 Mar 1
Manganese: brain transport and emerging research needs.
2000 Jun
Persistent alterations in biomarkers of oxidative stress resulting from combined in utero and neonatal manganese inhalation.
2005 May
Alterations of oxidative stress biomarkers due to in utero and neonatal exposures of airborne manganese.
2006 Summer
Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity.
2007 Jun
Expression profile analysis of antioxidative stress and developmental pathway genes in the manganese-exposed intertidal copepod Tigriopus japonicus with 6K oligochip.
2013 Aug
Chronic exposure to manganese sulfate leads to adverse dose-dependent effects on the neurobehavioral ability of rats.
2016 Nov
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Curator's Comment: In vitro cytotoxicity of manganese oxide (MnO) using live/dead cell assay, lactate dehydrogenase assay, and reactive oxygen species detection with variation of the concentration of nanoparticles (5-500 ug/ml), incubation time (18-96 h), and different human cell lines (lung adenocarcinoma, breast cancer cells, and glioblastoma cells) was studied. The cytotoxic effect was negligible for 18 h incubation even at highest concentration of 500 ug/ml MnO nanoparticle.
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 01:47:30 UTC 2023
Edited
by admin
on Sat Dec 16 01:47:30 UTC 2023
Record UNII
F46LH60L4M
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MANGANOUS SULFATE TETRAHYDRATE
Common Name English
SULFURIC ACID, MANGANESE(2+) SALT, HYDRATE (1:1:4)
Common Name English
MANGANESE SULFATE (MNSO4) TETRAHYDRATE
Common Name English
MANGANESE SULPHATE TETRAHYDRATE
Systematic Name English
C.I. 77752
Common Name English
MANGANESE(2+) SULFATE TETRAHYDRATE
Systematic Name English
Manganese sulfate tetrahydrate [WHO-DD]
Common Name English
MANGANESE SULFATE TETRAHYDRATE
WHO-DD  
Systematic Name English
SULFURIC ACID, MANGANESE(2+) SALT (1:1), TETRAHYDRATE
Common Name English
Code System Code Type Description
MESH
C039798
Created by admin on Sat Dec 16 01:47:30 UTC 2023 , Edited by admin on Sat Dec 16 01:47:30 UTC 2023
PRIMARY
SMS_ID
100000092428
Created by admin on Sat Dec 16 01:47:30 UTC 2023 , Edited by admin on Sat Dec 16 01:47:30 UTC 2023
PRIMARY
PUBCHEM
22572548
Created by admin on Sat Dec 16 01:47:30 UTC 2023 , Edited by admin on Sat Dec 16 01:47:30 UTC 2023
PRIMARY
EPA CompTox
DTXSID001015565
Created by admin on Sat Dec 16 01:47:30 UTC 2023 , Edited by admin on Sat Dec 16 01:47:30 UTC 2023
PRIMARY
CHEBI
86358
Created by admin on Sat Dec 16 01:47:30 UTC 2023 , Edited by admin on Sat Dec 16 01:47:30 UTC 2023
PRIMARY
CAS
10101-68-5
Created by admin on Sat Dec 16 01:47:30 UTC 2023 , Edited by admin on Sat Dec 16 01:47:30 UTC 2023
PRIMARY
EVMPD
SUB22643
Created by admin on Sat Dec 16 01:47:30 UTC 2023 , Edited by admin on Sat Dec 16 01:47:30 UTC 2023
PRIMARY
FDA UNII
F46LH60L4M
Created by admin on Sat Dec 16 01:47:30 UTC 2023 , Edited by admin on Sat Dec 16 01:47:30 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
ANHYDROUS->SOLVATE