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Details

Stereochemistry ACHIRAL
Molecular Formula Mn.O4S.H2O
Molecular Weight 169.016
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MANGANESE SULFATE

SMILES

O.[Mn++].[O-]S([O-])(=O)=O

InChI

InChIKey=ISPYRSDWRDQNSW-UHFFFAOYSA-L
InChI=1S/Mn.H2O4S.H2O/c;1-5(2,3)4;/h;(H2,1,2,3,4);1H2/q+2;;/p-2

HIDE SMILES / InChI
Molecular Formula Mn
Molecular Weight 54.938
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula HO4S
Molecular Weight 97.071
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula HO
Molecular Weight 17.0073
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/SCOGS/ucm260883.htm

Manganese citrate is generally recognized as safe direct food additive. Manganese citrate complex has being used in the determination of liver enzyme activities in the aging process and following treatment with aminoethylisothiuronium bromide hydrobromide (AET).

CNS Activity

Originator

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Activator
1430
Activator
1430
Activator
1430
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Basic research
Unknown

Approved Use

Unknown
Primary
Approved
8429
Unknown

Approved Use

Manganese is used for prevention and treatment of manganese deficiency, a condition in which the body doesn’t have enough manganese.
Primary
Approved
8429
Unknown

Approved Use

Manganese is used for weak bones (osteoporosis).
Palliative
Approved
8429
Unknown

Approved Use

Early research suggests that taking manganese along with calcium helps improve symptoms of PMS, including pain, crying, loneliness, anxiety, restlessness, irritability, mood swings, depression, and tension.
Curative
Approved
8429
MANGANESE SULFATE

Approved Use

Manganese Sulfate Injection, USP is indicated for use as a supplement to intravenous solutions given for Total Parenteral Nutrition (TPN). Administration helps to maintain plasma levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
Primary
Approved
8429
MANGANESE SULFATE

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Cytochrome oxidase determination using a manganese citrate complex.
1970
Manganese citrate improves base-calling accuracy in DNA sequencing reactions using rhodamine-based fluorescent dye-terminators.
1999 Mar 1
Equilibrium and kinetics studies of reactions of manganese acetate, cobalt acetate, and bromide salts in acetic acid solutions.
2001 Jun 18
Differential ability of transition metals to induce pulmonary inflammation.
2001 Nov 15
Is the axial zero-field splitting parameter of tetragonally elongated high-spin manganese(III) complexes always negative?
2002 Jul 31
Manganese potentiates in vitro production of proinflammatory cytokines and nitric oxide by microglia through a nuclear factor kappa B-dependent mechanism.
2005 Mar
Decreased expression of inflammation-related genes following inhalation exposure to manganese.
2006 May
Controlled Synthesis of Hollow Manganese Oxide Nanocrystals.
2016 Feb
Yolk-Shell MnO@ZnMn(2) O(4) /N-C Nanorods Derived from α-MnO(2) /ZIF-8 as Anode Materials for Lithium Ion Batteries.
2016 Oct
Top-Down Strategy to Synthesize Mesoporous Dual Carbon Armored MnO Nanoparticles for Lithium-Ion Battery Anodes.
2017 Apr 12
Patents

Patents

04048185
23
05089050
24
05261953
23
05629274
23
05700944
23
06136455
24
06548713
23
07091342
25
07384965
26
07544707
26
07598266
24
07615520
24
08460631
23
20020169331
23
20050222440
23
20060205615
24
20060205744
23
20090196809
23
20110203659
23
6589693
23
6627256
23
7435361
26
7687047
23
CA2165259A1
23
CA2517370C
23
DE102016209961
23
EP1627663A3
23
JP 2001058829 A
23
US 3585022 A
23
US20150218342
23
US2825631
23
US2916504
23
US2952519
26

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Curator's Comment: In vitro cytotoxicity of manganese oxide (MnO) using live/dead cell assay, lactate dehydrogenase assay, and reactive oxygen species detection with variation of the concentration of nanoparticles (5-500 ug/ml), incubation time (18-96 h), and different human cell lines (lung adenocarcinoma, breast cancer cells, and glioblastoma cells) was studied. The cytotoxic effect was negligible for 18 h incubation even at highest concentration of 500 ug/ml MnO nanoparticle.
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:28:26 UTC 2023
Edited
by admin
on Fri Dec 15 15:28:26 UTC 2023
Record UNII
W00LYS4T26
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MANGANESE SULFATE
FCC   INCI   MART.   ORANGE BOOK   USP   USP-RS   VANDF  
INCI  
Official Name English
Manganese sulfate monohydrate [WHO-DD]
Common Name English
Manganese(2+) sulfate (1:1) monohydrate
Common Name English
MANGANESE SULFATE [ORANGE BOOK]
Common Name English
MANGANUM SULPHURICUM [HPUS]
Common Name English
MANGANESE SULFATE [VANDF]
Common Name English
MANGANESE(2+) SULPHATE (1:1) MONOHYDRATE
Common Name English
MANGANESE SULPHATE
Systematic Name English
MANGANESE SULPHATE MONOHYDRATE
Systematic Name English
SULFURIC ACID, MANGANESE(2+) SALT (1:1) MONOHYDRATE
Common Name English
MANGANUM SULPHURICUM
HPUS  
Common Name English
MANGANESE SULFATE MONOHYDRATE [EP MONOGRAPH]
Common Name English
MANGANESE SULFATE [USP IMPURITY]
Common Name English
MANGANESE SULFATE [INCI]
Common Name English
MANGANESE SULFATE MONOHYDRATE [MI]
Common Name English
MANGANESE SULFATE [MART.]
Common Name English
MANGANESE SULFATE MONOHYDRATE
EP   MI   WHO-DD  
Systematic Name English
MANGANESE SULFATE [USP MONOGRAPH]
Common Name English
MANGANESE SULFATE [FCC]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 184.1461
Created by admin on Fri Dec 15 15:28:26 UTC 2023 , Edited by admin on Fri Dec 15 15:28:26 UTC 2023
DSLD 3137 (Number of products:2)
Created by admin on Fri Dec 15 15:28:26 UTC 2023 , Edited by admin on Fri Dec 15 15:28:26 UTC 2023
NCI_THESAURUS C29730
Created by admin on Fri Dec 15 15:28:26 UTC 2023 , Edited by admin on Fri Dec 15 15:28:26 UTC 2023
Code System Code Type Description
EVMPD
SUB14476MIG
Created by admin on Fri Dec 15 15:28:26 UTC 2023 , Edited by admin on Fri Dec 15 15:28:26 UTC 2023
PRIMARY
MERCK INDEX
m7074
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PRIMARY Merck Index
CHEBI
86360
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PRIMARY
DRUG CENTRAL
4461
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PRIMARY
WIKIPEDIA
Manganese sulphate
Created by admin on Fri Dec 15 15:28:26 UTC 2023 , Edited by admin on Fri Dec 15 15:28:26 UTC 2023
PRIMARY
EPA CompTox
DTXSID4020795
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PRIMARY
EVMPD
SUB12138MIG
Created by admin on Fri Dec 15 15:28:26 UTC 2023 , Edited by admin on Fri Dec 15 15:28:26 UTC 2023
PRIMARY
CHEBI
86364
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PRIMARY
RXCUI
29268
Created by admin on Fri Dec 15 15:28:26 UTC 2023 , Edited by admin on Fri Dec 15 15:28:26 UTC 2023
PRIMARY RxNorm
DRUG BANK
DBSALT001360
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PRIMARY
RS_ITEM_NUM
1375149
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PRIMARY
PUBCHEM
177577
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PRIMARY
DAILYMED
W00LYS4T26
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PRIMARY
ChEMBL
CHEMBL1200557
Created by admin on Fri Dec 15 15:28:26 UTC 2023 , Edited by admin on Fri Dec 15 15:28:26 UTC 2023
PRIMARY
CAS
10034-96-5
Created by admin on Fri Dec 15 15:28:26 UTC 2023 , Edited by admin on Fri Dec 15 15:28:26 UTC 2023
PRIMARY
SMS_ID
100000080143
Created by admin on Fri Dec 15 15:28:26 UTC 2023 , Edited by admin on Fri Dec 15 15:28:26 UTC 2023
PRIMARY
FDA UNII
W00LYS4T26
Created by admin on Fri Dec 15 15:28:26 UTC 2023 , Edited by admin on Fri Dec 15 15:28:26 UTC 2023
PRIMARY
NCI_THESAURUS
C66054
Created by admin on Fri Dec 15 15:28:26 UTC 2023 , Edited by admin on Fri Dec 15 15:28:26 UTC 2023
PRIMARY
Related Record Type Details
Structure of MANGANOUS CATION
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of MANGANOUS CATION
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