| Stereochemistry | ACHIRAL |
| Molecular Formula | C22H26N4O14P2.Mn.4H |
| Molecular Weight | 691.3776 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H+].[H+].[H+].[H+].[Mn++].CC1=NC=C(COP([O-])([O-])=O)C(CN(CCN(CC([O-])=O)CC2=C(COP([O-])([O-])=O)C=NC(C)=C2O)CC([O-])=O)=C1O
InChI
InChIKey=QDQFSBKXQQZVTB-UHFFFAOYSA-L
InChI=1S/C22H32N4O14P2.Mn/c1-13-21(31)17(15(5-23-13)11-39-41(33,34)35)7-25(9-19(27)28)3-4-26(10-20(29)30)8-18-16(12-40-42(36,37)38)6-24-14(2)22(18)32;/h5-6,31-32H,3-4,7-12H2,1-2H3,(H,27,28)(H,29,30)(H2,33,34,35)(H2,36,37,38);/q;+2/p-2
| Molecular Formula | C22H30N4O14P2 |
| Molecular Weight | 636.4395 |
| Charge | -2 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | Mn |
| Molecular Weight | 54.938045 |
| Charge | 2 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Mangafodipir (sold under the brand name Teslascan as mangafodipir trisodium) is a contrast agent delivered intravenously to enhance contrast in magnetic resonance imaging (MRI) of the liver. Mangafodipir is a manganese (Mn2+) chelate with the ligand fodipir (dipyridoxyl diphosphate or DPDP). Mangafodipir trisodium is metabolised (dephosphorylated) and partially transmetallated (manganese exchanged for zinc) after intravenous administration. Manganese that is released from mangafodipir is taken up by hepatocytes thereby increasing the SI of normal liver tissue. This may result in an improvement of the detection of liver metastases, which usually have no hepatocytes. The metabolites of fodipir are renally excreted, whilst the biliary route mainly excretes manganese. Mangafodipir was withdrawn from the US market in 2003 and the European market in 2012.
CNS Activity
Originator
Approval Year
Cmax
AUC
T1/2
Doses
AEs
Sourcing
PubMed
Patents
Sample Use Guides
MnDPDP (Mangafodipir) relax phenylephrine precontracted bovine mesenteric artery strips in a concentration- dependent manner. Bovine arteries from the branch of the superior mesenteric artery were obtained from a local slaughter-house within 30 mm of slaughter. Specimens were immersed in a Krebs’ buffer solution, dissected free from surrounding tissues, opened longitudinally and cut into strips approximately 5 mm wide. In some arterial strips the endothelial cells were removed by gently rubbing the intimal surface with a wooden stick for 30 to 60 sec. When the arterial strips had reached a steady state of contraction, MnDPDP (Mangafodipir) were added to the organ baths, at concentrations of 0.1 to 1000 ı.tM. ACh was used as a positive control. EDRF-independent effects were examined by using arterial strips minus endothelium.
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