FODIPIR

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H32N4O14P2
Molecular Weight	638.4554
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(O)C(CN(CCN(CC(O)=O)CC2=C(COP(O)(O)=O)C=NC(C)=C2O)CC(O)=O)=C(COP(O)(O)=O)C=N1

InChI

InChIKey=SQKUFYLUXROIFM-UHFFFAOYSA-N

InChI=1S/C22H32N4O14P2/c1-13-21(31)17(15(5-23-13)11-39-41(33,34)35)7-25(9-19(27)28)3-4-26(10-20(29)30)8-18-16(12-40-42(36,37)38)6-24-14(2)22(18)32/h5-6,31-32H,3-4,7-12H2,1-2H3,(H,27,28)(H,29,30)(H2,33,34,35)(H2,36,37,38)

HIDE SMILES / InChI

Molecular Formula	C22H32N4O14P2
Molecular Weight	638.4554
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Prevention of 7β-hydroxycholesterol-induced cell death by mangafodipir is mediated through lysosomal and mitochondrial pathways.	2010-08-25	20452343
Pharmacokinetic-pharmacodynamic modeling of manganese after a single intravenous infusion of mangafodipir in patients with acute alcoholic hepatitis.	2009-10	19834427
Mangafodipir as a cytoprotective adjunct to chemotherapy--a case report.	2009	19169914
Value of manganese-enhanced T1- and T2-weighted MR cholangiography for differentiating cystic parenchymal lesions from cystic abnormalities which communicate with bile ducts.	2007-12-31	18159606
[Contrast-enhanced magnetic resonance cholangiography using gadolinium-EOB-DTPA. Preliminary experience and clinical applications].	2007-06	17965849
MR contrast agents for liver imaging: what, when, how.	2006-11-15	17102040
Characterization of focal liver lesions: use of mangafodipir trisodium (MnDPDP)-enhanced MR images.	2006-09	16941248
Ultrasound of living donor liver transplantation.	2006-04	21614227
Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir.	2006-02-15	16478742
The magnetic resonance imaging contrast agent mangafodipir exerts antitumor activity via a previously described superoxide dismutase mimetic activity.	2006-01-01	16397277
Characterization of hepatocellular tumors: value of mangafodipir-enhanced magnetic resonance imaging.	2005-03-18	15772534
Detection and characterization of focal hepatic lesions: mangafodipir vs. superparamagnetic iron oxide-enhanced magnetic resonance imaging.	2004-10	15390224
Magnetic resonance with manganese-DPDP (mangafodipir) of focal solid pancreatic lesions.	2004-09	15343134
Contrast-enhanced magnetic resonance cholangiography using mangafodipir compared with standard T2W MRC sequences: a pictorial essay.	2004-08	15269951
Antioxidant activity of mangafodipir is not a new finding.	2004-05	15094242
Mangafodipir prevents liver injury induced by acetaminophen in the mouse.	2003-11	14568259
Improved image contrast with mangafodipir trisodium (MnDPDP) during MR-guided percutaneous cryosurgery of the liver.	2003-07	12915191
Contrast-enhanced MRI of the liver with mangafodipir trisodium: imaging technique and results.	2002-03-09	11884777
Detection of malignant primary hepatic neoplasms with gadobenate dimeglumine (Gd-BOPTA) enhanced T1-weighted hepatocyte phase MR imaging: results of off-site blinded review in a phase-II multicenter trial.	2002-01-05	11754328
[Organ specific MRI contrast media in general practice].	2002	12621828
Volumetric MR imaging of the liver and applications.	2001-11	11694434
Contrast-enhanced magnetic resonance cholangiography versus heavily T2-weighted magnetic resonance cholangiography.	2001-11	11606846

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:58:26 GMT 2025` Edited by `admin` on `Mon Mar 31 17:58:26 GMT 2025`
Record UNII	P28BIW0UTB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FODIPIR

Official Name

English

DPDP

Preferred Name

English

FODIPIR [USAN]

Common Name

English

fodipir [INN]

Common Name

English

GLYCINE, N,N'-1,2-ETHANEDIYLBIS(N-((3-HYDROXY-2-METHYL-5-((PHOSPHONOOXY)METHYL)-4-PYRIDINYL)METHYL)-

Systematic Name

English

N,N'-1,2-ETHANEDIYLBIS(N-((3-HYDROXY-2-METHYL-5-((PHOSPHONOOXY)METHYL)-4-PYRIDINYL)METHYL)GLYCINE)

Systematic Name

English

Code System Code Type Description

EVMPD

SUB07772MIG