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Status:
US Previously Marketed
Source:
Solution of Formaldehyde U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Solution of Formaldehyde U.S.P.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Formaldehyde is a naturally occurring organic compound, and an important industrial precursor to many other materials and organic compounds. Formaldehyde solution (formalin) is used as a disinfectant. Formaldehyde vapors are toxic, upon entry formaldehyde reacts readily with macromolecules, including DNA to form DNA-protein and DNA-DNA cross-links.
Status:
US Previously Marketed
Source:
DL-alpha tocopheryl acetate
(1921)
Source URL:
First marketed in 1921
Class (Stereo):
CHEMICAL (MIXED)
Conditions:
dl-α-tocopheryl phosphate has a growth acceleration effect on domestic fowl. Also was confirmed, that in all investigated animals dl-α-tocopheryl phosphate has an ability to being converted into vitamin E.
Status:
US Previously Marketed
First marketed in 1921
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Aluminium silicate is a compound made from aluminum, oxygen and silicate that can take the form of a mineral as well as combine with water to make a clay. Aluminum silicate comes in three mineral forms: andalusite, kyanite and sillimanite, all of which have the chemical formula Al2SiO5 but have distinct crystal structures. When magnesium aluminum silicate is hydrated it becomes a clay known as kaolin, which is used for treating ailments such as diarrhea and to combat diaper rash as well as rashes from poison oak and poison ivy. When combined with magnesium and hydrated, the result is a clay mixture that sees common use in antacids as well as a thickener for cosmetics and other beauty products. It also appears as an inactive ingredient for deodorants. The kyanite form of aluminium silicate is used to create mullite for industrial use, and this compound is used by the ceramics industry as a refractory, as well as to manufacture electrical insulating materials and heating elements. Aluminium silicate (aluminum oxide silicate), under the brand name Adsorbin among others, is used as antidiarrheal agent and intestinal adsorbent. Kaolin (hydrated aluminum silicate) has traditionally been used internally to control diarrhea. Kaolin has also been used topically as an emollient and drying agent. Specifically, it has been used to dry oozing and weeping poison ivy, poison oak, and poison sumac rashes. It has also been used as a protectant for the temporary relief of anorectal itching and diaper rash.
Status:
US Previously Marketed
Source:
THEOMINAL RS THEOBROMINE by WINTHROP
(1961)
Source URL:
First marketed in 1921
Source:
Theobromine Sodio-Salicylate U.S.P.
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Theobromine is the primary alkaloid present in the cocoa and chocolate. Theobromine is found in the shells and beans of the cacao plant and it is extracted from the husks of the bean and used for the synthesis of caffeine. Theobromine is an adenosine A1 and A2a receptor antagonist. Thesodate is used as a vasodilator, a diuretic, and heart stimulant. And similar to caffeine, it may be useful in management of fatigue and orthostatic hypotension. The symptomatic adverse reactions produced by theobromine are more or less tolerable and if they become severe, they can be treated symptomatically, these include anxiety, restlessness, tremors, sleeplessness, nausea and vomiting, loss of appetite. Theobromine is currently not in use as a medicinal drug.
Status:
US Previously Marketed
Source:
Benzaldehyde U.S.P.
(1921)
Source URL:
First marketed in 1921
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Benzaldehyde is the simplest and possibly the most industrially useful member of the family of aromatic aldehydes. Benzaldehyde exists in nature, primarily in combined forms such as a glycoside in almond, apricot, cherry, and peach seeds. The characteristic benzaldehyde odor of oil of bitter almond occurs because of trace amounts of free benzaldehyde formed by hydrolysis of the glycoside amygdalin. Benzaldehyde is a versatile intermediate because of its reactive aldehyde hydrogen, its carbonyl group, and the benzene ring. Benzaldehyde is formed from phenylpyruvic acid, derived by the aminotransferase activity on phenylalanine, in the presence of high levels of Mn2+, and contributes to the generation of flavor compound during cheese ripening. Benzaldehyde is a synthetic flavoring substance, sanctioned by the U.S. Food and Drug Administration (FDA) to be generally recognized as safe (GRAS) for foods. Benzaldehyde is also recognized as safe for use as a bee repellant in the harvesting of honey. Benzaldehyde's most important use is in organic synthesis, where it is the raw material utilized to produce various aldehydes. Because Benzaldehyde rapidly metabolizes to Benzoic Acid in the skin, the available dermal irritation and sensitization data demonstrating no adverse reactions to Benzoic Acid were considered supportive of the safety of Benzaldehyde.
Status:
US Previously Marketed
Source:
Chrysarobin U.S.P.
(1921)
Source URL:
First marketed in 1921
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Chrysarobin was originally extracted from Goa powder, a substance deposited in the wood of Andira Araroba, Aguiar (Nat. Ord.—Leguminosae). Chrysarobin (1,8-dihydroxy-3-methyl-9-anthrone) has enol tautomer of 1,8,9-trihydroxy-3-methyl-anthracene. Chrysarobin exerts antipsoriatic action. The use of chrysarobin has a number of quite serious disadvantages, not the least of which is that it can result in severe staining and irritation of the skin. Chrysarobin is an anthrone skin tumor promoter.
Status:
US Previously Marketed
Source:
Ammoniated Glycyrrhizin U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Ammoniated Glycyrrhizin U.S.P.
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Glycyrrhizic Acid is specific compound isolated from licorice plants. Ammonium Glycyrrhizate (also known as GLYCYRRHIZIN, AMMONIATED) is a salt, was investigated to be a safe and is used as ingredient in the formulation of makeup, fragrance, hair care, skin care, shaving, personal hygiene and suntan products.
Status:
US Previously Marketed
Source:
Formic Acid N.F.
(1921)
Source URL:
First marketed in 1921
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Formic acid is the simplest carboxylic acid. In nature, formic acid is found in the stings and bites of many insects of the order Hymenoptera, including bees and ants. The principal use of formic acid is as a preservative and antibacterial agent in livestock feed. When sprayed on fresh hay or other silage, it arrests certain decay processes and causes the feed to retain its nutritive value longer. In medicine 85% formic acid application is a safe, economical, and effective alternative in the treatment of common warts with few side-effects and good compliance.
Status:
US Previously Marketed
Source:
Merphenyl Acetate by Hamilton
(1937)
Source URL:
First marketed in 1921
Class (Stereo):
CHEMICAL (ACHIRAL)
Phenylmercuric ammonium acetate is a fungicide and bactericide. It is used for the seed treatment.
Status:
US Previously Marketed
Source:
Zinc Stearate U.S.P.
(1921)
Source URL:
First marketed in 1921
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Zinc stearate is a mild antiseptic and astringent, and it has been used as a local soothing application for inflammatory and irritating skin diseases. Zinc stearate is primarily used in pharmacuetical formulations as a lubricant in tablet and capsule manufacture at concentrations up to 1.5% w/w. It is a protective agent used in powders and ointments in the treatment of eczema, acne, and other skin diseases. GRAS - Zinc stearate complies with FDA Standard CFR 21 sections 177.2600, 182.8994 and 178.2010.