U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula CH2O2
Molecular Weight 46.0254
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FORMIC ACID

SMILES

C(=O)O

InChI

InChIKey=BDAGIHXWWSANSR-UHFFFAOYSA-N
InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)

HIDE SMILES / InChI
Formic acid is the simplest carboxylic acid. In nature, formic acid is found in the stings and bites of many insects of the order Hymenoptera, including bees and ants. The principal use of formic acid is as a preservative and antibacterial agent in livestock feed. When sprayed on fresh hay or other silage, it arrests certain decay processes and causes the feed to retain its nutritive value longer. In medicine 85% formic acid application is a safe, economical, and effective alternative in the treatment of common warts with few side-effects and good compliance.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
EndWarts PEN

Approved Use

EndWarts PEN is a unique and effective wart treatment
PubMed

PubMed

TitleDatePubMed
Folding units in calcium vector protein of amphioxus: Structural and functional properties of its amino- and carboxy-terminal halves.
2001 Apr
Co-oximetry interference by hemoglobin-based blood substitutes.
2001 Apr
Ryanodine receptors/calcium release channels in heart failure and sudden cardiac death.
2001 Apr
Growth kinetics, diffraction properties and effect of agarose on the stability of a novel crystal form of Thermus thermophilus aspartyl-tRNA synthetase-1.
2001 Apr
Bicarbonate/lactate-based peritoneal dialysis solution increases cancer antigen 125 and decreases hyaluronic acid levels.
2001 Apr
Influence of particle size in the effect of polyethylene on human osteoblastic cells.
2001 Apr
Long-lived glycosyl-enzyme intermediate mimic produced by formate re-activation of a mutant endoglucanase lacking its catalytic nucleophile.
2001 Apr 1
Targeting of calsequestrin to the sarcoplasmic reticulum of skeletal muscle upon deletion of its glycosylation site.
2001 Apr 15
Functional proteins from a random-sequence library.
2001 Apr 5
A comparison of salts for the crystallization of macromolecules.
2001 Feb
Nonaqueous capillary electrophoresis-mass spectrometry for separation of venlafaxine and its phase I metabolites.
2001 Feb
Synthesis and biological evaluation of 2-(3'-(1H-tetrazol-5-yl) bicyclo[1.1.1]pent-1-yl)glycine (S-TBPG), a novel mGlu1 receptor antagonist.
2001 Feb
Conformational preferences of heterochiral peptides. Crystal structures of heterochiral peptides Boc-(D) Val-(D) Ala-Leu-Ala-OMe and Boc-Val-Ala-Leu-(D) Ala-OMe--enhanced stability of beta-sheet through C-H...O hydrogen bonds.
2001 Feb
Papain does not cleave operator-bound lambda repressor: structural characterization of the carboxy terminal domain and the hinge.
2001 Feb
[Radiolytic oxidation of tamoxifen with the free radicals OH- and/or HO2-].
2001 Feb
Alternative splicing and sequence diversity of transcripts from the oncosphere stage of Taenia solium with homology to the 45W antigen of Taenia ovis.
2001 Feb
Characterization of the product ions from the collision-induced dissociation of argentinated peptides.
2001 Feb
Fully automated 96-well liquid-liquid extraction for analysis of biological samples by liquid chromatography with tandem mass spectrometry.
2001 Feb 1
Exchange coupling in carboxylato-bridged dinuclear copper(II) compounds: a density functional study.
2001 Feb 2
Synthesis, crystal structure, spectral studies, and catechol oxidase activity of trigonal bipyramidal Cu(II) complexes derived from a tetradentate diamide bisbenzimidazole ligand.
2001 Feb 26
Laboratory study on the high-temperature capture of HCl gas by dry-injection of calcium-based sorbents.
2001 Feb-Mar
Formate species in the low-temperature oxidation of dimethyl ether.
2001 Feb-Mar
Solution structure and backbone dynamics of the DNA-binding domain of mouse Sox-5.
2001 Jan
Biodegradation of ethyl t-butyl ether (ETBE), methyl t-butyl ether (MTBE) and t-amyl methyl ether (TAME) by Gordonia terrae.
2001 Jan
The Streptomyces venezuelae pikAV gene contains a transcription unit essential for expression of enzymes involved in glycosylation of narbonolide and 10-deoxymethynolide.
2001 Jan 24
Controlled proteolysis of amelogenins reveals exposure of both carboxy- and amino-terminal regions.
2001 Jun
Serum crosslaps correlations with serum ICTP and urine DPD in hemodialyzed and peritoneally dialyzed patients.
2001 Mar
A novel type II cytokeratin, mK6irs, is expressed in the Huxley and Henle layers of the mouse inner root sheath.
2001 Mar
Ultrasonic irradiation of dichlorvos: decomposition mechanism.
2001 Mar
Molecular comparison of the dense granule proteins GRA6 and GRA7 of Neospora hughesi and Neospora caninum.
2001 Mar
Crystallization and preliminary X-ray crystallographic analysis of RNase HIII from Bacillus subtilis.
2001 Mar
Purification and crystallization of the human RXRalpha ligand-binding domain-9-cisRA complex.
2001 Mar
Structure of the M148Q mutant of rusticyanin at 1.5 A: a model for the copper site of stellacyanin.
2001 Mar
Three-dimensional structure of human follicle-stimulating hormone.
2001 Mar
Differential recovery of retinal function after mitochondrial inhibition by methanol intoxication.
2001 Mar
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
2001 Mar 1
SCO-spondin, a glycoprotein of the subcommissural organ/Reissner's fiber complex: evidence of a potent activity on neuronal development in primary cell cultures.
2001 Mar 1
Extracellular carbonic anhydrase activity facilitates lactic acid transport in rat skeletal muscle fibres.
2001 Mar 15
The hydH/G Genes from Escherichia coli code for a zinc and lead responsive two-component regulatory system.
2001 Mar 16
Conserved amino acids near the carboxy terminus of bacterial tyrosyl-tRNA synthetase are involved in tRNA and Tyr-AMP binding.
2001 Mar 2
Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemia.
2001 Mar 23
Expression of monocarboxylate transporter MCT1 in normal and neoplastic human CNS tissues.
2001 Mar 26
SuperStar: improved knowledge-based interaction fields for protein binding sites.
2001 Mar 30
Quantitation of itraconazole in rat heparinized plasma by liquid chromatography-mass spectrometry.
2001 Mar 5
Unusually short distances between the carbonyl oxygen and the tin atom in RCOSMR'3 (M = Ge, Sn, Pb): the importance of intramolecular n(O) --> sigma*(MS) orbital interactions.
2001 Mar 8
NAD/NADH models with axial/central chiralities: superiority of the quinoline ring system.
2001 Mar 9
Topology of the Na(+)/dicarboxylate cotransporter: the N-terminus and hydrophilic loop 4 are located intracellularly.
2001 Mar 9
Mouse MCT3 gene is expressed preferentially in retinal pigment and choroid plexus epithelia.
2001 May
Diet-induced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain.
2001 May
Crystal structure of activated CheY. Comparison with other activated receiver domains.
2001 May 11
Patents

Sample Use Guides

Fifty patients received 85% formic acid application using a topical application/needle puncture technique every other day.
Route of Administration: Topical
The adapted Aureobasidium pullulans strain could grow under the stress of 0.5 g/L furfural, 3 g/L HMF, 2g/L acetic acid, and 0.5 g/L formic acid, whereas the wild type did not.
Name Type Language
FORMIC ACID
FCC   FHFI   HSDB   INCI   MART.   MI   USP-RS   VANDF   WHO-DD  
INCI  
Official Name English
VARROMED COMPONENT FORMIC ACID
Brand Name English
FORMIC ACID [MART.]
Common Name English
FORMIC ACID [EP MONOGRAPH]
Common Name English
FORMICUM ACIDUM [HPUS]
Common Name English
FORMIC ACID [FHFI]
Common Name English
FORMIC ACID [MI]
Common Name English
FEMA NO. 2487
Code English
FORMIC ACID COMPONENT OF VARROMED
Brand Name English
METHANOIC ACID
Systematic Name English
FORMIC ACID [FCC]
Common Name English
FORMIC ACID [INCI]
Common Name English
FORMICUM ACIDUM
HPUS  
Common Name English
FORMIC ACID [EMA EPAR VETERINARY]
Common Name English
FORMIC ACID [VANDF]
Common Name English
FORMIC ACID [WHO-DD]
Common Name English
FORMIC ACID [HSDB]
Common Name English
FORMIC ACID [USP-RS]
Common Name English
Classification Tree Code System Code
JECFA EVALUATION FORMIC ACID
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
EMA VETERINARY ASSESSMENT REPORTS VARROMED [AUTHORIZED]
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
DSLD 4255 (Number of products:2)
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
WHO-VATC QP53AG01
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
EPA PESTICIDE CODE 214900
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
CFR 21 CFR 186.1316
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
CFR 21 CFR 172.515
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
Code System Code Type Description
DRUG BANK
DB01942
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
PRIMARY
HSDB
1646
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
PRIMARY
USP_CATALOG
1283200
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
PRIMARY USP-RS
NCI_THESAURUS
C45678
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
CONCEPT Industrial Aid
EVMPD
SUB13916MIG
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
PRIMARY
FDA UNII
0YIW783RG1
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
PRIMARY
EPA CompTox
64-18-6
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
PRIMARY
NCI_THESAURUS
C83719
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
PRIMARY
PUBCHEM
284
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
PRIMARY
MERCK INDEX
M5539
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
PRIMARY Merck Index
MESH
C030544
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
PRIMARY
WIKIPEDIA
FORMIC ACID
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
PRIMARY
CAS
64-18-6
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
PRIMARY
RXCUI
4537
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
PRIMARY RxNorm
ECHA (EC/EINECS)
200-579-1
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
PRIMARY
RXCUI
1362748
Created by admin on Fri Jun 25 21:08:30 UTC 2021 , Edited by admin on Fri Jun 25 21:08:30 UTC 2021
PRIMARY