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Details

Stereochemistry ACHIRAL
Molecular Formula CH2O
Molecular Weight 30.026
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FORMALDEHYDE

SMILES

C=O

InChI

InChIKey=WSFSSNUMVMOOMR-UHFFFAOYSA-N
InChI=1S/CH2O/c1-2/h1H2

HIDE SMILES / InChI

Molecular Formula CH2O
Molecular Weight 30.026
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment:: https://www.drugs.com/pro/formaldehyde-liquid.html

Formaldehyde is a naturally occurring organic compound, and an important industrial precursor to many other materials and organic compounds. Formaldehyde solution (formalin) is used as a disinfectant. Formaldehyde vapors are toxic, upon entry formaldehyde reacts readily with macromolecules, including DNA to form DNA-protein and DNA-DNA cross-links.

Originator

Curator's Comment:: Formaldehyde was first reported in 1859 by the Russian chemist Aleksandr Butlerov

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: CHEMBL2311221
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
FORMALDEHYDE 10%

Approved Use

Drying agent for pre and post surgical removal of warts, or for non-surgical laser treatment of warts where dryness is required. Safeguards against offensive odor and dries excessive moisture of feet. Not to be used in patients known to be sensitive to any of the ingredients in this product.
PubMed

PubMed

TitleDatePubMed
NAD-linked, factor-dependent formaldehyde dehydrogenase or trimeric, zinc-containing, long-chain alcohol dehydrogenase from Amycolatopsis methanolica.
1992 Jun 1
Crystal structure of an electron-transfer complex between methylamine dehydrogenase and amicyanin.
1992 Jun 2
The L-arginine/nitric oxide/cyclic-GMP pathway apparently mediates the peripheral antihyperalgesic action of fentanyl in rats.
2003 Dec
Potentiation of allergic bronchoconstriction by repeated exposure to formaldehyde in guinea-pigs in vivo.
2003 Dec
[Scleroderma and occupational risk factors: a case-control study].
2003 Jul-Sep
Systemic contact dermatitis of the eyelids caused by formaldehyde derived from aspartame?
2003 Nov
[Effects of formaldehyde on germ cells of male mice].
2003 Nov
Inhalation of low-level formaldehyde enhances nerve growth factor production in the hippocampus of mice.
2004
Multiple formaldehyde oxidation/detoxification pathways in Burkholderia fungorum LB400.
2004 Apr
Differential immunogenic and neurogenic inflammatory responses in an allergic mouse model exposed to low levels of formaldehyde.
2004 Apr 1
Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor.
2004 Apr 26
Diagnosis and treatment of dermatitis due to formaldehyde resins in clothing.
2004 Dec
A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1.
2004 Dec
GABAA receptor partially mediated propofol-induced hyperalgesia at superspinal level and analgesia at spinal cord level in rats.
2004 Dec
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.
2004 Dec 29
Protein associated with Myc (PAM) is involved in spinal nociceptive processing.
2004 Feb
Reproducibility of patch tests: comparison of identical test allergens from different commercial sources.
2004 Jan
Effect of prolonged exposure to low concentrations of formaldehyde on the corticotropin releasing hormone neurons in the hypothalamus and adrenocorticotropic hormone cells in the pituitary gland in female mice.
2004 Jul 2
Allergic contact sensitivity in elderly patients.
2004 Jun
Hepatocyte proliferation in chronic hepatitis C: correlation with degree of liver disease and serum alpha-fetoprotein.
2004 Jun
Biodegradation of alachlor by soil streptomycetes.
2004 Jun
Mortality from solid cancers among workers in formaldehyde industries.
2004 Jun 15
Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdeydes unsaturated sesquiterpenes polygodial and drimanial in rats.
2004 Mar
[Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations].
2004 May
Investigations into the antinociceptive activity of Sapindus trifoliatus in various pain models.
2004 May
Long-term exposure to low levels of formaldehyde increases the number of tyrosine hydroxylase-immunopositive periglomerular cells in mouse main olfactory bulb.
2004 May 8
The implausibility of leukemia induction by formaldehyde: a critical review of the biological evidence on distant-site toxicity.
2004 Oct
[Allergy to formaldehyde].
2004 Sep
Protein cross-linkage induced by formaldehyde derived from semicarbazide-sensitive amine oxidase-mediated deamination of methylamine.
2004 Sep
Use of the platelet reactivity index by Grotemeyer, platelet function analyzer, and retention test Homburg to monitor therapy with antiplatelet drugs.
2005
Transcriptomic analysis of F344 rat nasal epithelium suggests that the lack of carcinogenic response to glutaraldehyde is due to its greater toxicity compared to formaldehyde.
2005
Effect of formaldehyde gas exposure in a murine allergic contact hypersensitivity model.
2005
Supratentorial primitive neuroectodermal tumours of the brain: multidirectional differentiation does not influence prognosis. A clinicopathological report of 18 patients.
2005 Apr
Antinociceptive properties of mixture of alpha-amyrin and beta-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways.
2005 Apr
Protective effect of NAC on formaldehyde-containing-ZOE-based root-canal-sealers-induced cyclooxygenase-2 expression and cytotoxicity in human osteoblastic cells.
2005 Aug
Methanol, formaldehyde, and sodium formate exposure in rat and mouse conceptuses: a potential role of the visceral yolk sac in embryotoxicity.
2005 Feb
The role of intracellularly released formaldehyde and butyric acid in the anticancer activity of acyloxyalkyl esters.
2005 Feb 24
An ecological study of the association of environmental chemicals on breast cancer incidence in Texas.
2005 Jul
p53 protein expression in chronic hepatitis C; effect of interferon alpha 2b therapy.
2005 Jul-Aug
Contact sensitivity to preservatives in Turkey.
2005 Jun
Hypothalamo-pituitary-adrenal gland axis in mice inhaling toluene prior to low-level long-term exposure to formaldehyde.
2005 Mar
Redox imbalance induced by contact sensitizers triggers the maturation of dendritic cells.
2005 Mar
[Study on differential display genes of tolerant-damage of MRC-5 induced by formaldehyde of low dose].
2005 May
Vitamin E against oxidative damage caused by formaldehyde in frontal cortex and hippocampus: biochemical and histological studies.
2005 May
The interaction of trimethylamine dehydrogenase and electron-transferring flavoprotein.
2005 May 27
Postmortem distribution of sildenafil in histological material.
2005 May-Jun
Thrombotic thrombocytopenic purpura causing rapid unexpected death: value of CD61 immunohistochemical staining in diagnosis.
2005 May-Jun
Detection of chlamydial bodies and antigens in the central nervous system of patients with multiple sclerosis.
2005 Oct 1
Identification of N,N-dimethylamphetamine formed by methylation of methamphetamine in formalin-fixed liver tissue by multistage mass spectrometry.
2006 Mar 10
Protective effects of omega-3 essential fatty acids against formaldehyde-induced neuronal damage in prefrontal cortex of rats.
2006 May-Jun
Patents

Sample Use Guides

Formaldehyde 10% solution is applied topically once a day to affected areas.
Route of Administration: Topical
In Vitro Use Guide
Human lymphoblasts were exposed in vitro to various concentrations of formaldehyde (HCHO) in single and multiple treatment regimens to determine relative mutagenic efficiency. HCHO treatment resulted in a significant nonlinear increase in DNA-protein crosslinks at concentrations greater than 50 uM X 2 h, which correlated with the onset of significant toxicity in this cell line.
Substance Class Chemical
Created
by admin
on Sat Jun 26 00:37:44 UTC 2021
Edited
by admin
on Sat Jun 26 00:37:44 UTC 2021
Record UNII
1HG84L3525
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FORMALDEHYDE
II   INCI   MI   VANDF  
INCI  
Official Name English
OXOMETHANE
Systematic Name English
SUPERLYSOFORM
Common Name English
FORMALDEHYDE [VANDF]
Common Name English
PARAFORM
Common Name English
FORMALDEHYDE [IARC]
Common Name English
FORMALDEHYDE [MI]
Common Name English
NSC-298885
Code English
FORMALDEHYDE [II]
Common Name English
METHANAL
Systematic Name English
LYSOFORM
Common Name English
FORMIC ALDEHYDE
Common Name English
OXYMETHYLENE
Common Name English
FORMALDEHYDE [INCI]
Common Name English
METHYLENE OXIDE
Systematic Name English
Classification Tree Code System Code
WHO-VATC QP53AX19
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
NCI_THESAURUS C45175
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
NDF-RT N0000185508
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
CFR 21 CFR 176.170
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
IARC Formaldehyde
NCI_THESAURUS C94714
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
CFR 21 CFR 173.340
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
CFR 21 CFR 175.210
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
Code System Code Type Description
NDF-RT
N0000171131
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
PRIMARY Allergens [Chemical/Ingredient]
CAS
50-00-0
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
PRIMARY
FDA UNII
1HG84L3525
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
PRIMARY
DRUG CENTRAL
3244
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
PRIMARY
RXCUI
314636
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
ALTERNATIVE
WIKIPEDIA
FORMALDEHYDE
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
PRIMARY
NCI_THESAURUS
C29744
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
PRIMARY
IARC
Formaldehyde
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
PRIMARY
MERCK INDEX
M5533
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
PRIMARY Merck Index
NDF-RT
N0000184306
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
PRIMARY Cell-mediated Immunity [PE]
PUBCHEM
712
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
PRIMARY
NDF-RT
N0000175629
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
PRIMARY Increased Histamine Release [PE]
ChEMBL
CHEMBL1255
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
PRIMARY
DRUG BANK
DB03843
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
PRIMARY
MESH
D005557
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
PRIMARY
EVMPD
SUB12505MIG
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
PRIMARY
RXCUI
4530
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
PRIMARY
ECHA (EC/EINECS)
200-001-8
Created by admin on Sat Jun 26 00:37:44 UTC 2021 , Edited by admin on Sat Jun 26 00:37:44 UTC 2021
PRIMARY
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PARENT -> METABOLITE
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ACTIVE MOIETY