Details
Stereochemistry | ACHIRAL |
Molecular Formula | CH2O |
Molecular Weight | 30.026 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C=O
InChI
InChIKey=WSFSSNUMVMOOMR-UHFFFAOYSA-N
InChI=1S/CH2O/c1-2/h1H2
Molecular Formula | CH2O |
Molecular Weight | 30.026 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.drugbank.ca/drugs/DB03843Curator's Comment: description was created based on several sources, including
https://www.nap.edu/read/13142/chapter/6 |
https://www.drugs.com/pro/formaldehyde-liquid.html
Sources: https://www.drugbank.ca/drugs/DB03843
Curator's Comment: description was created based on several sources, including
https://www.nap.edu/read/13142/chapter/6 |
https://www.drugs.com/pro/formaldehyde-liquid.html
Formaldehyde is a naturally occurring organic compound, and an important industrial precursor to many other materials and organic compounds. Formaldehyde solution (formalin) is used as a disinfectant. Formaldehyde vapors are toxic, upon entry formaldehyde reacts readily with macromolecules, including DNA to form DNA-protein and DNA-DNA cross-links.
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2311221 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3796657 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Curative | FORMALDEHYDE 10% Approved UseDrying agent for pre and post surgical removal of warts, or for non-surgical laser treatment of warts where dryness is required. Safeguards against offensive odor and dries excessive moisture of feet. Not to be used in patients known to be sensitive to any of the ingredients in this product. |
PubMed
Title | Date | PubMed |
---|---|---|
NAD-linked, factor-dependent formaldehyde dehydrogenase or trimeric, zinc-containing, long-chain alcohol dehydrogenase from Amycolatopsis methanolica. | 1992 Jun 1 |
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[The enhancement of formalin induced agitation behavior by intrathecal administration of prostaglandin E1]. | 1999 Aug |
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The involvement of K+ channels and Gi/o protein in the antinociceptive action of the gallic acid ethyl ester. | 1999 Aug 20 |
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Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice. | 1999 Dec |
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Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist. | 1999 Sep |
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Characterization of metabolites during biodegradation of hexahydro-1, 3,5-trinitro-1,3,5-triazine (RDX) with municipal anaerobic sludge. | 2000 Jun |
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Occupational asthma due to formaldehyde. | 2001 Aug |
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Sensitizing capacity of two monomeric aldehyde components in p-tert-butylphenol-formaldehyde resin. | 2002 |
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IgE-mediated urticaria from formaldehyde in a dental root canal compound. | 2002 |
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Antiprotozoals effective in vitro against the scuticociliate fish pathogen Philasterides dicentrarchi. | 2002 Jun 3 |
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Expression of cytokine mRNAs in mice cutaneously exposed to formaldehyde. | 2002 Oct 21 |
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Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain. | 2003 Apr |
|
Extended follow-up of a cohort of british chemical workers exposed to formaldehyde. | 2003 Nov 5 |
|
Antinociceptive profile of (-)-spectaline: a piperidine alkaloid from Cassia leptophylla. | 2003 Sep |
|
Inhalation of low-level formaldehyde enhances nerve growth factor production in the hippocampus of mice. | 2004 |
|
A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1. | 2004 Dec |
|
GABAA receptor partially mediated propofol-induced hyperalgesia at superspinal level and analgesia at spinal cord level in rats. | 2004 Dec |
|
Hepatocyte proliferation in chronic hepatitis C: correlation with degree of liver disease and serum alpha-fetoprotein. | 2004 Jun |
|
Biodegradation of alachlor by soil streptomycetes. | 2004 Jun |
|
Mortality from solid cancers among workers in formaldehyde industries. | 2004 Jun 15 |
|
Long-term exposure to low levels of formaldehyde increases the number of tyrosine hydroxylase-immunopositive periglomerular cells in mouse main olfactory bulb. | 2004 May 8 |
|
Protective effect of NAC on formaldehyde-containing-ZOE-based root-canal-sealers-induced cyclooxygenase-2 expression and cytotoxicity in human osteoblastic cells. | 2005 Aug |
|
Methanol, formaldehyde, and sodium formate exposure in rat and mouse conceptuses: a potential role of the visceral yolk sac in embryotoxicity. | 2005 Feb |
|
Redox imbalance induced by contact sensitizers triggers the maturation of dendritic cells. | 2005 Mar |
|
The interaction of trimethylamine dehydrogenase and electron-transferring flavoprotein. | 2005 May 27 |
|
Postmortem distribution of sildenafil in histological material. | 2005 May-Jun |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.drugs.com/pro/formaldehyde-liquid.html
Formaldehyde 10% solution is applied topically once a day to affected areas.
Route of Administration:
Topical
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3796657
Human lymphoblasts were exposed in vitro to various concentrations of formaldehyde (HCHO) in single and multiple treatment regimens to determine relative mutagenic efficiency. HCHO treatment resulted in a significant nonlinear increase in DNA-protein crosslinks at concentrations greater than 50 uM X 2 h, which correlated with the onset of significant toxicity in this cell line.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 16 19:02:00 UTC 2022
by
admin
on
Fri Dec 16 19:02:00 UTC 2022
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Record UNII |
1HG84L3525
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Record Status |
Validated (UNII)
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Record Version |
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-
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Classification Tree | Code System | Code | ||
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WHO-VATC |
QP53AX19
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NCI_THESAURUS |
C45175
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NDF-RT |
N0000185508
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CFR |
21 CFR 176.170
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IARC | Formaldehyde | ||
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NCI_THESAURUS |
C94714
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CFR |
21 CFR 173.340
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CFR |
21 CFR 175.210
Created by
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Code System | Code | Type | Description | ||
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formaldehyde
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PRIMARY | |||
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N0000171131
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PRIMARY | Allergens [Chemical/Ingredient] | ||
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50-00-0
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PRIMARY | |||
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1HG84L3525
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PRIMARY | |||
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3244
Created by
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PRIMARY | |||
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314636
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ALTERNATIVE | |||
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FORMALDEHYDE
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PRIMARY | |||
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C29744
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PRIMARY | |||
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Formaldehyde
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M5533
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PRIMARY | Merck Index | ||
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16842
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PRIMARY | |||
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61538
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PRIMARY | |||
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N0000184306
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PRIMARY | Cell-mediated Immunity [PE] | ||
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712
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PRIMARY | |||
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31962
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PRIMARY | |||
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298885
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N0000175629
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PRIMARY | Increased Histamine Release [PE] | ||
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CHEMBL1255
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PRIMARY | |||
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1HG84L3525
Created by
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DB03843
Created by
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D005557
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SUB12505MIG
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4530
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PRIMARY | |||
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200-001-8
Created by
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PRIMARY |
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