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Details

Stereochemistry ACHIRAL
Molecular Formula CH2O
Molecular Weight 30.026
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Formaldehyde

SMILES

C=O

InChI

InChIKey=WSFSSNUMVMOOMR-UHFFFAOYSA-N
InChI=1S/CH2O/c1-2/h1H2

HIDE SMILES / InChI

Molecular Formula CH2O
Molecular Weight 30.026
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.nap.edu/read/13142/chapter/6 | https://www.drugs.com/pro/formaldehyde-liquid.html

Formaldehyde is a naturally occurring organic compound, and an important industrial precursor to many other materials and organic compounds. Formaldehyde solution (formalin) is used as a disinfectant. Formaldehyde vapors are toxic, upon entry formaldehyde reacts readily with macromolecules, including DNA to form DNA-protein and DNA-DNA cross-links.

Originator

Curator's Comment: Formaldehyde was first reported in 1859 by the Russian chemist Aleksandr Butlerov

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: CHEMBL2311221
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
FORMALDEHYDE 10%

Approved Use

Drying agent for pre and post surgical removal of warts, or for non-surgical laser treatment of warts where dryness is required. Safeguards against offensive odor and dries excessive moisture of feet. Not to be used in patients known to be sensitive to any of the ingredients in this product.
PubMed

PubMed

TitleDatePubMed
Intravesical formalin for the control of intractable bladder hemorrhage secondary to cystitis or cancer.
1975 Oct
Endodontic treatment of permanent teeth in children with a new calcium-carbamide-formaldehyde paste.
2002
Sensitizing capacity of two monomeric aldehyde components in p-tert-butylphenol-formaldehyde resin.
2002
Formaldehyde enhances mite allergen-induced eosinophilic inflammation in the murine airway.
2002
IgE-mediated urticaria from formaldehyde in a dental root canal compound.
2002
Domestic exposure to formaldehyde significantly increases the risk of asthma in young children.
2002 Aug
Contact dermatitis to phenol-formaldehyde resin in two plywood factory workers.
2002 Aug
Morphine microinjections into the rat nucleus submedius depress nociceptive behavior in the formalin test.
2002 Aug 9
Results of long-term experimental studies on the carcinogenicity of formaldehyde and acetaldehyde in rats.
2002 Dec
Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival.
2002 Nov
Expression of cytokine mRNAs in mice cutaneously exposed to formaldehyde.
2002 Oct 21
A role for peripheral somatostatin receptors in counter-irritation-induced analgesia.
2003
Glutaraldehyde-induced and formaldehyde-induced allergic contact dermatitis among dental hygienists and assistants.
2003 Aug
The L-arginine/nitric oxide/cyclic-GMP pathway apparently mediates the peripheral antihyperalgesic action of fentanyl in rats.
2003 Dec
Potentiation of allergic bronchoconstriction by repeated exposure to formaldehyde in guinea-pigs in vivo.
2003 Dec
Contact dermatitis from electrocardiograph-monitoring electrodes: role of p-tert-butylphenol-formaldehyde resin.
2003 Feb
Structure-function relationships in human Class III alcohol dehydrogenase (formaldehyde dehydrogenase).
2003 Feb 1
Formaldehyde application for haemorrhagic radiation-induced proctitis: a clinical and histological study.
2003 Jan
[Formaldehyde exposure levels and exposure control measures during an anatomy dissecting course].
2003 Jun
Formaldehyde-induced gene expression in F344 rat nasal respiratory epithelium.
2003 May 1
[Effects of formaldehyde on germ cells of male mice].
2003 Nov
Extended follow-up of a cohort of british chemical workers exposed to formaldehyde.
2003 Nov 5
Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat.
2003 Oct
Combined effects of tumor promoters and serum on proliferin mRNA induction: a biomarker sensitive to saccharin, 2,3,7,8-TCDD, and other compounds at minimal concentrations promoting C3H/10T1/2 cell transformation.
2003 Oct 24
Pathological effects of formalin (37% formaldehyde) mixed in feed or administered into the crops of White Leghorn cockerels.
2003 Sep
Antinociceptive profile of (-)-spectaline: a piperidine alkaloid from Cassia leptophylla.
2003 Sep
Inhalation of low-level formaldehyde enhances nerve growth factor production in the hippocampus of mice.
2004
Multiple formaldehyde oxidation/detoxification pathways in Burkholderia fungorum LB400.
2004 Apr
Differential immunogenic and neurogenic inflammatory responses in an allergic mouse model exposed to low levels of formaldehyde.
2004 Apr 1
Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor.
2004 Apr 26
Protein associated with Myc (PAM) is involved in spinal nociceptive processing.
2004 Feb
Reproducibility of patch tests: comparison of identical test allergens from different commercial sources.
2004 Jan
Effect of prolonged exposure to low concentrations of formaldehyde on the corticotropin releasing hormone neurons in the hypothalamus and adrenocorticotropic hormone cells in the pituitary gland in female mice.
2004 Jul 2
Allergic contact sensitivity in elderly patients.
2004 Jun
Hepatocyte proliferation in chronic hepatitis C: correlation with degree of liver disease and serum alpha-fetoprotein.
2004 Jun
Biodegradation of alachlor by soil streptomycetes.
2004 Jun
Mortality from solid cancers among workers in formaldehyde industries.
2004 Jun 15
Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdeydes unsaturated sesquiterpenes polygodial and drimanial in rats.
2004 Mar
Investigations into the antinociceptive activity of Sapindus trifoliatus in various pain models.
2004 May
The implausibility of leukemia induction by formaldehyde: a critical review of the biological evidence on distant-site toxicity.
2004 Oct
Use of the platelet reactivity index by Grotemeyer, platelet function analyzer, and retention test Homburg to monitor therapy with antiplatelet drugs.
2005
Transcriptomic analysis of F344 rat nasal epithelium suggests that the lack of carcinogenic response to glutaraldehyde is due to its greater toxicity compared to formaldehyde.
2005
Protective effect of NAC on formaldehyde-containing-ZOE-based root-canal-sealers-induced cyclooxygenase-2 expression and cytotoxicity in human osteoblastic cells.
2005 Aug
Methanol, formaldehyde, and sodium formate exposure in rat and mouse conceptuses: a potential role of the visceral yolk sac in embryotoxicity.
2005 Feb
An ecological study of the association of environmental chemicals on breast cancer incidence in Texas.
2005 Jul
Contact sensitivity to preservatives in Turkey.
2005 Jun
[Study on differential display genes of tolerant-damage of MRC-5 induced by formaldehyde of low dose].
2005 May
Thrombotic thrombocytopenic purpura causing rapid unexpected death: value of CD61 immunohistochemical staining in diagnosis.
2005 May-Jun
Detection of chlamydial bodies and antigens in the central nervous system of patients with multiple sclerosis.
2005 Oct 1
Identification of N,N-dimethylamphetamine formed by methylation of methamphetamine in formalin-fixed liver tissue by multistage mass spectrometry.
2006 Mar 10
Patents

Sample Use Guides

Formaldehyde 10% solution is applied topically once a day to affected areas.
Route of Administration: Topical
In Vitro Use Guide
Human lymphoblasts were exposed in vitro to various concentrations of formaldehyde (HCHO) in single and multiple treatment regimens to determine relative mutagenic efficiency. HCHO treatment resulted in a significant nonlinear increase in DNA-protein crosslinks at concentrations greater than 50 uM X 2 h, which correlated with the onset of significant toxicity in this cell line.
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:16:56 GMT 2025
Edited
by admin
on Mon Mar 31 18:16:56 GMT 2025
Record UNII
1HG84L3525
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Formaldehyde
II   INCI   MI   VANDF  
INCI  
Official Name English
NSC-298885
Preferred Name English
Oxomethane
Systematic Name English
Superlysoform
Common Name English
Formaldehyde [VANDF]
Common Name English
Paraform
Common Name English
Formaldehyde [IARC]
Common Name English
Formaldehyde [MI]
Common Name English
Formaldehyde [II]
Common Name English
Methanal
Systematic Name English
Lysoform
Common Name English
Formic aldehyde
Common Name English
Oxymethylene
Common Name English
Methylene oxide
Systematic Name English
Classification Tree Code System Code
WHO-VATC QP53AX19
Created by admin on Mon Mar 31 18:16:56 GMT 2025 , Edited by admin on Mon Mar 31 18:16:56 GMT 2025
NCI_THESAURUS C45175
Created by admin on Mon Mar 31 18:16:57 GMT 2025 , Edited by admin on Mon Mar 31 18:16:57 GMT 2025
NDF-RT N0000185508
Created by admin on Mon Mar 31 18:16:56 GMT 2025 , Edited by admin on Mon Mar 31 18:16:56 GMT 2025
CFR 21 CFR 176.170
Created by admin on Mon Mar 31 18:16:56 GMT 2025 , Edited by admin on Mon Mar 31 18:16:56 GMT 2025
IARC Formaldehyde
NCI_THESAURUS C94714
Created by admin on Mon Mar 31 18:16:57 GMT 2025 , Edited by admin on Mon Mar 31 18:16:57 GMT 2025
CFR 21 CFR 173.340
Created by admin on Mon Mar 31 18:16:56 GMT 2025 , Edited by admin on Mon Mar 31 18:16:56 GMT 2025
CFR 21 CFR 175.210
Created by admin on Mon Mar 31 18:16:56 GMT 2025 , Edited by admin on Mon Mar 31 18:16:56 GMT 2025
Code System Code Type Description
ALANWOOD
formaldehyde
Created by admin on Mon Mar 31 18:16:57 GMT 2025 , Edited by admin on Mon Mar 31 18:16:57 GMT 2025
PRIMARY
NDF-RT
N0000171131
Created by admin on Mon Mar 31 18:16:56 GMT 2025 , Edited by admin on Mon Mar 31 18:16:56 GMT 2025
PRIMARY Allergens [Chemical/Ingredient]
CAS
50-00-0
Created by admin on Mon Mar 31 18:16:56 GMT 2025 , Edited by admin on Mon Mar 31 18:16:56 GMT 2025
PRIMARY
FDA UNII
1HG84L3525
Created by admin on Mon Mar 31 18:16:57 GMT 2025 , Edited by admin on Mon Mar 31 18:16:57 GMT 2025
PRIMARY
DRUG CENTRAL
3244
Created by admin on Mon Mar 31 18:16:57 GMT 2025 , Edited by admin on Mon Mar 31 18:16:57 GMT 2025
PRIMARY
RXCUI
314636
Created by admin on Mon Mar 31 18:16:56 GMT 2025 , Edited by admin on Mon Mar 31 18:16:56 GMT 2025
ALTERNATIVE
WIKIPEDIA
FORMALDEHYDE
Created by admin on Mon Mar 31 18:16:56 GMT 2025 , Edited by admin on Mon Mar 31 18:16:56 GMT 2025
PRIMARY
NCI_THESAURUS
C29744
Created by admin on Mon Mar 31 18:16:56 GMT 2025 , Edited by admin on Mon Mar 31 18:16:56 GMT 2025
PRIMARY
IARC
Formaldehyde
Created by admin on Mon Mar 31 18:16:57 GMT 2025 , Edited by admin on Mon Mar 31 18:16:57 GMT 2025
PRIMARY
SMS_ID
100000092801
Created by admin on Mon Mar 31 18:16:57 GMT 2025 , Edited by admin on Mon Mar 31 18:16:57 GMT 2025
PRIMARY
EPA CompTox
DTXSID7020637
Created by admin on Mon Mar 31 18:16:57 GMT 2025 , Edited by admin on Mon Mar 31 18:16:57 GMT 2025
PRIMARY
MERCK INDEX
m5533
Created by admin on Mon Mar 31 18:16:56 GMT 2025 , Edited by admin on Mon Mar 31 18:16:56 GMT 2025
PRIMARY Merck Index
CHEBI
16842
Created by admin on Mon Mar 31 18:16:57 GMT 2025 , Edited by admin on Mon Mar 31 18:16:57 GMT 2025
PRIMARY
CHEBI
61538
Created by admin on Mon Mar 31 18:16:57 GMT 2025 , Edited by admin on Mon Mar 31 18:16:57 GMT 2025
PRIMARY
NDF-RT
N0000184306
Created by admin on Mon Mar 31 18:16:56 GMT 2025 , Edited by admin on Mon Mar 31 18:16:56 GMT 2025
PRIMARY Cell-mediated Immunity [PE]
PUBCHEM
712
Created by admin on Mon Mar 31 18:16:56 GMT 2025 , Edited by admin on Mon Mar 31 18:16:56 GMT 2025
PRIMARY
CHEBI
31962
Created by admin on Mon Mar 31 18:16:57 GMT 2025 , Edited by admin on Mon Mar 31 18:16:57 GMT 2025
PRIMARY
NSC
298885
Created by admin on Mon Mar 31 18:16:57 GMT 2025 , Edited by admin on Mon Mar 31 18:16:57 GMT 2025
PRIMARY
NDF-RT
N0000175629
Created by admin on Mon Mar 31 18:16:56 GMT 2025 , Edited by admin on Mon Mar 31 18:16:56 GMT 2025
PRIMARY Increased Histamine Release [PE]
ChEMBL
CHEMBL1255
Created by admin on Mon Mar 31 18:16:56 GMT 2025 , Edited by admin on Mon Mar 31 18:16:56 GMT 2025
PRIMARY
DAILYMED
1HG84L3525
Created by admin on Mon Mar 31 18:16:57 GMT 2025 , Edited by admin on Mon Mar 31 18:16:57 GMT 2025
PRIMARY
DRUG BANK
DB03843
Created by admin on Mon Mar 31 18:16:56 GMT 2025 , Edited by admin on Mon Mar 31 18:16:56 GMT 2025
PRIMARY
MESH
D005557
Created by admin on Mon Mar 31 18:16:56 GMT 2025 , Edited by admin on Mon Mar 31 18:16:56 GMT 2025
PRIMARY
EVMPD
SUB12505MIG
Created by admin on Mon Mar 31 18:16:56 GMT 2025 , Edited by admin on Mon Mar 31 18:16:56 GMT 2025
PRIMARY
RXCUI
4530
Created by admin on Mon Mar 31 18:16:56 GMT 2025 , Edited by admin on Mon Mar 31 18:16:56 GMT 2025
PRIMARY
ECHA (EC/EINECS)
200-001-8
Created by admin on Mon Mar 31 18:16:56 GMT 2025 , Edited by admin on Mon Mar 31 18:16:56 GMT 2025
PRIMARY
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