Formaldehyde

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	CH2O
Molecular Weight	30.026
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C=O

InChI

InChIKey=WSFSSNUMVMOOMR-UHFFFAOYSA-N

InChI=1S/CH2O/c1-2/h1H2

HIDE SMILES / InChI

Molecular Formula	CH2O
Molecular Weight	30.026
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugbank.ca/drugs/DB03843
Curator's Comment: description was created based on several sources, including https://www.nap.edu/read/13142/chapter/6 | https://www.drugs.com/pro/formaldehyde-liquid.html

Formaldehyde is a naturally occurring organic compound, and an important industrial precursor to many other materials and organic compounds. Formaldehyde solution (formalin) is used as a disinfectant. Formaldehyde vapors are toxic, upon entry formaldehyde reacts readily with macromolecules, including DNA to form DNA-protein and DNA-DNA cross-links.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
DNA 278 Target ID: CHEMBL2311221 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3796657	Crosslinking Agent 81

Conditions

Condition	Modality	Targets	Highest Phase	Product
Warts 9 Sources: https://www.drugs.com/pro/formaldehyde-liquid.html	Curative		Approved 8429	FORMALDEHYDE 10% Approved Use Drying agent for pre and post surgical removal of warts, or for non-surgical laser treatment of warts where dryness is required. Safeguards against offensive odor and dries excessive moisture of feet. Not to be used in patients known to be sensitive to any of the ingredients in this product.

PubMed

Title	Date	PubMed
Crystal structure of an electron-transfer complex between methylamine dehydrogenase and amicyanin.	1992 Jun 2	1599920
Endodontic treatment of permanent teeth in children with a new calcium-carbamide-formaldehyde paste.	2002	12751685
Sensitizing capacity of two monomeric aldehyde components in p-tert-butylphenol-formaldehyde resin.	2002	12575846
IgE-mediated urticaria from formaldehyde in a dental root canal compound.	2002	12371530
Results of long-term experimental studies on the carcinogenicity of formaldehyde and acetaldehyde in rats.	2002 Dec	12562630
A role for peripheral somatostatin receptors in counter-irritation-induced analgesia.	2003	12890519
Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain.	2003 Apr	12595749
Glutaraldehyde-induced and formaldehyde-induced allergic contact dermatitis among dental hygienists and assistants.	2003 Aug	12956347
Potentiation of allergic bronchoconstriction by repeated exposure to formaldehyde in guinea-pigs in vivo.	2003 Dec	14656365
Formaldehyde application for haemorrhagic radiation-induced proctitis: a clinical and histological study.	2003 Jan	12780922
[Formaldehyde exposure levels and exposure control measures during an anatomy dissecting course].	2003 Jun	12833854
Extended follow-up of a cohort of british chemical workers exposed to formaldehyde.	2003 Nov 5	14600093
Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat.	2003 Oct	12857938
Combined effects of tumor promoters and serum on proliferin mRNA induction: a biomarker sensitive to saccharin, 2,3,7,8-TCDD, and other compounds at minimal concentrations promoting C3H/10T1/2 cell transformation.	2003 Oct 24	14514435
Pathological effects of formalin (37% formaldehyde) mixed in feed or administered into the crops of White Leghorn cockerels.	2003 Sep	14633228
Antinociceptive profile of (-)-spectaline: a piperidine alkaloid from Cassia leptophylla.	2003 Sep	14598202
Inhalation of low-level formaldehyde enhances nerve growth factor production in the hippocampus of mice.	2004	15467352
Multiple formaldehyde oxidation/detoxification pathways in Burkholderia fungorum LB400.	2004 Apr	15028703
Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor.	2004 Apr 26	15102535
Diagnosis and treatment of dermatitis due to formaldehyde resins in clothing.	2004 Dec	15842060
A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1.	2004 Dec	15606755
GABAA receptor partially mediated propofol-induced hyperalgesia at superspinal level and analgesia at spinal cord level in rats.	2004 Dec	15569406
Protein associated with Myc (PAM) is involved in spinal nociceptive processing.	2004 Feb	14756816
Reproducibility of patch tests: comparison of identical test allergens from different commercial sources.	2004 Jan	15059100
Effect of prolonged exposure to low concentrations of formaldehyde on the corticotropin releasing hormone neurons in the hypothalamus and adrenocorticotropic hormone cells in the pituitary gland in female mice.	2004 Jul 2	15196973
Allergic contact sensitivity in elderly patients.	2004 Jun	15462465
Hepatocyte proliferation in chronic hepatitis C: correlation with degree of liver disease and serum alpha-fetoprotein.	2004 Jun	15189269
Mortality from solid cancers among workers in formaldehyde industries.	2004 Jun 15	15191929
[Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations].	2004 May	15218738
Investigations into the antinociceptive activity of Sapindus trifoliatus in various pain models.	2004 May	15142344
Long-term exposure to low levels of formaldehyde increases the number of tyrosine hydroxylase-immunopositive periglomerular cells in mouse main olfactory bulb.	2004 May 8	15064152
The implausibility of leukemia induction by formaldehyde: a critical review of the biological evidence on distant-site toxicity.	2004 Oct	15450713
Protein cross-linkage induced by formaldehyde derived from semicarbazide-sensitive amine oxidase-mediated deamination of methylamine.	2004 Sep	15128865
Use of the platelet reactivity index by Grotemeyer, platelet function analyzer, and retention test Homburg to monitor therapy with antiplatelet drugs.	2005	16149025
Transcriptomic analysis of F344 rat nasal epithelium suggests that the lack of carcinogenic response to glutaraldehyde is due to its greater toxicity compared to formaldehyde.	2005	16036858
Effect of formaldehyde gas exposure in a murine allergic contact hypersensitivity model.	2005	15803868
Supratentorial primitive neuroectodermal tumours of the brain: multidirectional differentiation does not influence prognosis. A clinicopathological report of 18 patients.	2005 Apr	15810952
Protective effect of NAC on formaldehyde-containing-ZOE-based root-canal-sealers-induced cyclooxygenase-2 expression and cytotoxicity in human osteoblastic cells.	2005 Aug	15934011
Methanol, formaldehyde, and sodium formate exposure in rat and mouse conceptuses: a potential role of the visceral yolk sac in embryotoxicity.	2005 Feb	15578646
The role of intracellularly released formaldehyde and butyric acid in the anticancer activity of acyloxyalkyl esters.	2005 Feb 24	15715472
An ecological study of the association of environmental chemicals on breast cancer incidence in Texas.	2005 Jul	15986119
p53 protein expression in chronic hepatitis C; effect of interferon alpha 2b therapy.	2005 Jul-Aug	16001656
Hypothalamo-pituitary-adrenal gland axis in mice inhaling toluene prior to low-level long-term exposure to formaldehyde.	2005 Mar	15805735
Redox imbalance induced by contact sensitizers triggers the maturation of dendritic cells.	2005 Mar	15737199
[Study on differential display genes of tolerant-damage of MRC-5 induced by formaldehyde of low dose].	2005 May	16111024
Vitamin E against oxidative damage caused by formaldehyde in frontal cortex and hippocampus: biochemical and histological studies.	2005 May	15820619
The interaction of trimethylamine dehydrogenase and electron-transferring flavoprotein.	2005 May 27	15760891
Detection of chlamydial bodies and antigens in the central nervous system of patients with multiple sclerosis.	2005 Oct 1	16136465
Identification of N,N-dimethylamphetamine formed by methylation of methamphetamine in formalin-fixed liver tissue by multistage mass spectrometry.	2006 Mar 10	15893897
Protective effects of omega-3 essential fatty acids against formaldehyde-induced neuronal damage in prefrontal cortex of rats.	2006 May-Jun	15648056

Patents

Sample Use Guides

In Vivo Use Guide

Formaldehyde 10% solution is applied topically once a day to affected areas.

Route of Administration: Topical

In Vitro Use Guide

Human lymphoblasts were exposed in vitro to various concentrations of formaldehyde (HCHO) in single and multiple treatment regimens to determine relative mutagenic efficiency. HCHO treatment resulted in a significant nonlinear increase in DNA-protein crosslinks at concentrations greater than 50 uM X 2 h, which correlated with the onset of significant toxicity in this cell line.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:02:24 GMT 2023` Edited by `admin` on `Fri Dec 15 16:02:24 GMT 2023`
Record UNII	1HG84L3525
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Formaldehyde

Official Name

English

OXOMETHANE

Systematic Name

English

SUPERLYSOFORM

Common Name

English

FORMALDEHYDE [VANDF]

Common Name

English

PARAFORM

Common Name

English

FORMALDEHYDE [IARC]

Common Name

English

FORMALDEHYDE [MI]

Common Name

English

NSC-298885

Code

English

FORMALDEHYDE [II]

Common Name

English

METHANAL

Systematic Name

English

LYSOFORM

Common Name

English

FORMIC ALDEHYDE

Common Name

English

OXYMETHYLENE

Common Name

English

FORMALDEHYDE [INCI]

Common Name

English

METHYLENE OXIDE

Systematic Name

English

Classification Tree Code System Code

WHO-VATC

QP53AX19