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Details

Stereochemistry ACHIRAL
Molecular Formula CH2O
Molecular Weight 30.026
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Formaldehyde

SMILES

C=O

InChI

InChIKey=WSFSSNUMVMOOMR-UHFFFAOYSA-N
InChI=1S/CH2O/c1-2/h1H2

HIDE SMILES / InChI
Molecular Formula CH2O
Molecular Weight 30.026
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.nap.edu/read/13142/chapter/6 | https://www.drugs.com/pro/formaldehyde-liquid.html

Formaldehyde is a naturally occurring organic compound, and an important industrial precursor to many other materials and organic compounds. Formaldehyde solution (formalin) is used as a disinfectant. Formaldehyde vapors are toxic, upon entry formaldehyde reacts readily with macromolecules, including DNA to form DNA-protein and DNA-DNA cross-links.

CNS Activity

Originator

Butlerov, A.
15
Curator's Comment: Formaldehyde was first reported in 1859 by the Russian chemist Aleksandr Butlerov

Approval Year

1921
1447
Targets

Targets

Primary TargetPharmacologyConditionPotency
DNA
241
Target ID: CHEMBL2311221
Crosslinking Agent
77
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8307
FORMALDEHYDE 10%

Approved Use

Drying agent for pre and post surgical removal of warts, or for non-surgical laser treatment of warts where dryness is required. Safeguards against offensive odor and dries excessive moisture of feet. Not to be used in patients known to be sensitive to any of the ingredients in this product.
PubMed

PubMed

TitleDatePubMed
NAD-linked, factor-dependent formaldehyde dehydrogenase or trimeric, zinc-containing, long-chain alcohol dehydrogenase from Amycolatopsis methanolica.
1992 Jun 1
[The enhancement of formalin induced agitation behavior by intrathecal administration of prostaglandin E1].
1999 Aug
The involvement of K+ channels and Gi/o protein in the antinociceptive action of the gallic acid ethyl ester.
1999 Aug 20
Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice.
1999 Dec
Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist.
1999 Sep
Characterization of metabolites during biodegradation of hexahydro-1, 3,5-trinitro-1,3,5-triazine (RDX) with municipal anaerobic sludge.
2000 Jun
Occupational asthma due to formaldehyde.
2001 Aug
Sensitizing capacity of two monomeric aldehyde components in p-tert-butylphenol-formaldehyde resin.
2002
IgE-mediated urticaria from formaldehyde in a dental root canal compound.
2002
Antiprotozoals effective in vitro against the scuticociliate fish pathogen Philasterides dicentrarchi.
2002 Jun 3
Expression of cytokine mRNAs in mice cutaneously exposed to formaldehyde.
2002 Oct 21
Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain.
2003 Apr
Extended follow-up of a cohort of british chemical workers exposed to formaldehyde.
2003 Nov 5
Antinociceptive profile of (-)-spectaline: a piperidine alkaloid from Cassia leptophylla.
2003 Sep
Inhalation of low-level formaldehyde enhances nerve growth factor production in the hippocampus of mice.
2004
A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1.
2004 Dec
GABAA receptor partially mediated propofol-induced hyperalgesia at superspinal level and analgesia at spinal cord level in rats.
2004 Dec
Hepatocyte proliferation in chronic hepatitis C: correlation with degree of liver disease and serum alpha-fetoprotein.
2004 Jun
Biodegradation of alachlor by soil streptomycetes.
2004 Jun
Mortality from solid cancers among workers in formaldehyde industries.
2004 Jun 15
Long-term exposure to low levels of formaldehyde increases the number of tyrosine hydroxylase-immunopositive periglomerular cells in mouse main olfactory bulb.
2004 May 8
Protective effect of NAC on formaldehyde-containing-ZOE-based root-canal-sealers-induced cyclooxygenase-2 expression and cytotoxicity in human osteoblastic cells.
2005 Aug
Methanol, formaldehyde, and sodium formate exposure in rat and mouse conceptuses: a potential role of the visceral yolk sac in embryotoxicity.
2005 Feb
Redox imbalance induced by contact sensitizers triggers the maturation of dendritic cells.
2005 Mar
The interaction of trimethylamine dehydrogenase and electron-transferring flavoprotein.
2005 May 27
Postmortem distribution of sildenafil in histological material.
2005 May-Jun
Patents

Patents

03944600
5
03954756
5
03969409
5
03976653
4
03992389
5
03994941
6
03996278
7
03997527
3
04002746
11
04005140
7
04009160
3
04009274
3
04016281
4
04024186
3
04031093
4

Sample Use Guides

In Vivo Use Guide
Formaldehyde 10% solution is applied topically once a day to affected areas.
Route of Administration: Topical
In Vitro Use Guide
Human lymphoblasts were exposed in vitro to various concentrations of formaldehyde (HCHO) in single and multiple treatment regimens to determine relative mutagenic efficiency. HCHO treatment resulted in a significant nonlinear increase in DNA-protein crosslinks at concentrations greater than 50 uM X 2 h, which correlated with the onset of significant toxicity in this cell line.
Substance Class Chemical
Created
by admin
on Fri Dec 16 19:02:00 UTC 2022
Edited
by admin
on Fri Dec 16 19:02:00 UTC 2022
Record UNII
1HG84L3525
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Formaldehyde
II   INCI   MI   VANDF  
INCI  
Official Name English
OXOMETHANE
Systematic Name English
SUPERLYSOFORM
Common Name English
FORMALDEHYDE [VANDF]
Common Name English
PARAFORM
Common Name English
FORMALDEHYDE [IARC]
Common Name English
FORMALDEHYDE [MI]
Common Name English
NSC-298885
Code English
FORMALDEHYDE [II]
Common Name English
METHANAL
Systematic Name English
LYSOFORM
Common Name English
FORMIC ALDEHYDE
Common Name English
OXYMETHYLENE
Common Name English
FORMALDEHYDE [INCI]
Common Name English
METHYLENE OXIDE
Systematic Name English
Classification Tree Code System Code
WHO-VATC QP53AX19
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
NCI_THESAURUS C45175
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
NDF-RT N0000185508
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
CFR 21 CFR 176.170
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
IARC Formaldehyde
NCI_THESAURUS C94714
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
CFR 21 CFR 173.340
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
CFR 21 CFR 175.210
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
Code System Code Type Description
ALANWOOD
formaldehyde
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY
NDF-RT
N0000171131
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY Allergens [Chemical/Ingredient]
CAS
50-00-0
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY
FDA UNII
1HG84L3525
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY
DRUG CENTRAL
3244
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY
RXCUI
314636
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
ALTERNATIVE
WIKIPEDIA
FORMALDEHYDE
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY
NCI_THESAURUS
C29744
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY
IARC
Formaldehyde
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY
MERCK INDEX
M5533
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY Merck Index
CHEBI
16842
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY
CHEBI
61538
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY
NDF-RT
N0000184306
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY Cell-mediated Immunity [PE]
PUBCHEM
712
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY
CHEBI
31962
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY
NSC
298885
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY
NDF-RT
N0000175629
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY Increased Histamine Release [PE]
ChEMBL
CHEMBL1255
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY
DAILYMED
1HG84L3525
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY
DRUG BANK
DB03843
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY
MESH
D005557
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY
EVMPD
SUB12505MIG
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY
RXCUI
4530
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY
ECHA (EC/EINECS)
200-001-8
Created by admin on Fri Dec 16 19:02:00 UTC 2022 , Edited by admin on Fri Dec 16 19:02:00 UTC 2022
PRIMARY
Related Record Type Details
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Related Record Type Details
Structure of Formaldehyde
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