U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C2H6N2O
Molecular Weight 74.0819
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of N-NITROSODIMETHYLAMINE

SMILES

CN(C)N=O

InChI

InChIKey=UMFJAHHVKNCGLG-UHFFFAOYSA-N
InChI=1S/C2H6N2O/c1-4(2)3-5/h1-2H3

HIDE SMILES / InChI

Molecular Formula C2H6N2O
Molecular Weight 74.0819
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Meat consumption and risk of stomach cancer in Uruguay: a case-control study.
2001
[Clinico-experimental basis for regional and systemic administration of thiopoietins in liver cirrhosis. Report I].
2001
O6-alkylguanines, dietary N-nitroso compounds, and their precursors in gastric cancer.
2001
The influence of very low doses of N-nitrosodimethylamine (NDMA) on the apoptosis of rat neutrophils in vivo. The role of reactive oxygen species.
2001 Aug 13
Mixture of N-carbamoyl-L-glutamate plus L-arginine can protect rats with liver cirrhosis from acute ammonia intoxication.
2001 Dec
Cytochrome b(5) coexpression increases the CYP2E1-dependent mutagenicity of dialkylnitrosamines in methyltransferase-deficient strains of Salmonella typhimurium.
2001 Dec 12
Carbon tetrachloride changes the activity of cytochrome P450 system in the liver of male rats: role of antioxidants.
2001 Dec 14
Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis.
2001 Feb
Effects of octreotide on intestinal transit and bacterial translocation in conscious rats with portal hypertension and liver fibrosis.
2001 Nov
Rat oesophageal cytochrome P450 (CYP) monooxygenase system: comparison to the liver and relevance in N-nitrosodiethylamine carcinogenesis.
2001 Nov
S9 induction by the combined treatment with cyclohexanol and albendazole.
2001 Nov
Dimethyl sulfoxide inhibits dimethylnitrosamine-induced hepatic fibrosis in rats.
2001 Nov
Role of human cytochrome P450 (CYP) in the metabolic activation of N-alkylnitrosamines: application of genetically engineered Salmonella typhimurium YG7108 expressing each form of CYP together with human NADPH-cytochrome P450 reductase.
2001 Nov 1
[The role of xanthine oxidase in the cytotoxic action of nitrates and nitrites].
2001 Nov-Dec
TAC-101, a novel retinobenzoic-acid derivative, enhances gap junctional intercellular communication among renal epithelial cells treated with renal carcinogens.
2001 Nov-Dec
Assessment of chronic toxicity and carcinogenicity in an accelerated cancer bioassay in rats of moxifloxacin, a quinolone antibiotic.
2001 Oct
Cell type-specific induction of O6-alkylguanine-DNA alkyltransferase mRNA expression in rat liver during regeneration, inflammation and preneoplasia.
2001 Oct
Lack of effect of furfural on unscheduled DNA synthesis in the in vivo rat and mouse hepatocyte DNA repair assays and in precision-cut human liver slices.
2001 Oct
Esophageal cancer prevention in zinc-deficient rats: rapid induction of apoptosis by replenishing zinc.
2001 Oct 17
Incidence and effects of Ha-ras codon 12 G-->A transition mutations in preneoplastic lesions induced by N-nitrosomethylbenzylamine in the rat esophagus.
2001 Sep
Intragastric volatile N-nitrosamines, nitrite, pH, and Helicobacter pylori during long-term treatment with omeprazole.
2001 Sep
Increased oxidative stress in dimethylnitrosamine-induced liver fibrosis in the rat: effect of N-acetylcysteine and interferon-alpha.
2001 Sep 1
N-nitrososdimethylamine is activated in microsomes from hepatocytes to reactive metabolites which damage DNA of non-parenchymal cells in rat liver.
2001 Sep 15
Determination of N-nitrosodimethylamine in environmental aqueous samples by isotope-dilution GC/MS-SIM.
2001 Sep-Oct
A kinetic model of N-nitrosodimethylamine (NDMA) formation during water chlorination/chloramination.
2002
Preliminary evaluation of the cytotoxic and genotoxic potential of D-003: Mixture of very long chain fatty acids.
2002
Alcohol induction of liver nuclear ethanol and N-nitrosodimethylamine metabolism to reactive metabolites.
2002
Mechanistic studies of N-nitrosodimethylamine (NDMA) formation in chlorinated drinking water.
2002 Apr
CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.
2002 Apr
Microsome-mediated oxidation of N-nitrosodiethanolamine (NDELA), a bident carcinogen.
2002 Apr
Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer.
2002 Aug
Effects of extract derived from Eriobotrya japonica on liver function improvement in rats.
2002 Aug
Functional role of cytochrome p-450 2a3 in N-nitrosomethylbenzylamine metabolism in rat esophagus.
2002 Aug 9
Formation of N-nitrosodimethylamine (NDMA) from reaction of monochloramine: a new disinfection by-product.
2002 Feb
Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
2002 Feb 15
Formation of N-nitrosodimethylamine (NDMA) from dimethylamine during chlorination.
2002 Feb 15
Structure-activity relationships of several anisidine and dibenzanthracene isomers in the w/w+ somatic assay of Drosophila melanogaster.
2002 Feb 15
Fast microwave-assisted dansylation of N-nitrosamines. Analysis by high-performance liquid chromatography with fluorescence detection.
2002 Feb 8
Antimutagenic and anticarcinogenic effects of Phyllanthus amarus.
2002 Jan
Susceptibility of liver proliferative lesions in heterozygous p53 deficient CBA mice to various carcinogens.
2002 Jul
Transgenic rats carrying human c-Ha-ras proto-oncogene are highly susceptible to N-nitrosomethylbenzylamine induction of esophageal tumorigenesis.
2002 Jul
Impairment of activation of hepatocyte growth factor precursor into its mature form in rats with liver cirrhosis.
2002 Jul
Volatile N-nitrosamine inhibition after intake Korean green tea and Maesil (Prunus mume SIEB. et ZACC.) extracts with an amine-rich diet in subjects ingesting nitrate.
2002 Jul
Rapid in vivo assay for topical oral cancer chemopreventive agents.
2002 Jul
DNA adducts and liver DNA replication in rats during chronic exposure to N-nitrosodimethylamine (NDMA) and their relationships to the dose-dependence of NDMA hepatocarcinogenesis.
2002 Mar 20
Effect of ethanol treatment on metabolic activation and detoxification of esophagus carcinogenic N-nitrosamines in rat liver.
2002 May
Effect of some hypoglycemic herbs on the activity of phase I and II drug-metabolizing enzymes in alloxan-induced diabetic rats.
2002 May 24
Cytochrome P450 2E1 dependent catalytic activity and lipid peroxidation in rat blood lymphocytes.
2002 Oct 11
Monitoring of nitrite and N-nitrosamine levels in irradiated pork sausage.
2002 Sep
Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol.
2002 Sep
Patents

Patents

Substance Class Chemical
Created
by admin
on Sat Jun 26 02:21:39 UTC 2021
Edited
by admin
on Sat Jun 26 02:21:39 UTC 2021
Record UNII
M43H21IO8R
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
N-NITROSODIMETHYLAMINE
HSDB   MI  
Systematic Name English
DIMETHYLNITROSAMINE
Common Name English
N-NITROSODIMETHYLAMINE [HSDB]
Common Name English
N-NITROSODIMETHYLAMINE [USP-RS]
Common Name English
DMN
Common Name English
N-NITROSODIMETHYLAMINE [IARC]
Common Name English
NDMA
Common Name English
DMNA
Common Name English
METHANAMINE, N-METHYL-N-NITROSO-
Systematic Name English
NSC-23226
Code English
NMDA (GENOTOXIC)
Common Name English
N-NITROSODIMETHYLAMINE [MI]
Common Name English
N-METHYL-N-NITROSOMETHANAMINE
Systematic Name English
Classification Tree Code System Code
IARC <i>N</i>-Nitrosodimethylamine
NCI_THESAURUS C45398
Created by admin on Sat Jun 26 02:21:40 UTC 2021 , Edited by admin on Sat Jun 26 02:21:40 UTC 2021
Code System Code Type Description
MERCK INDEX
M7994
Created by admin on Sat Jun 26 02:21:40 UTC 2021 , Edited by admin on Sat Jun 26 02:21:40 UTC 2021
PRIMARY Merck Index
WIKIPEDIA
N-NITROSODIMETHYLAMINE
Created by admin on Sat Jun 26 02:21:40 UTC 2021 , Edited by admin on Sat Jun 26 02:21:40 UTC 2021
PRIMARY
HSDB
1667
Created by admin on Sat Jun 26 02:21:40 UTC 2021 , Edited by admin on Sat Jun 26 02:21:40 UTC 2021
PRIMARY
EPA CompTox
62-75-9
Created by admin on Sat Jun 26 02:21:40 UTC 2021 , Edited by admin on Sat Jun 26 02:21:40 UTC 2021
PRIMARY
MESH
D004128
Created by admin on Sat Jun 26 02:21:40 UTC 2021 , Edited by admin on Sat Jun 26 02:21:40 UTC 2021
PRIMARY
PUBCHEM
6124
Created by admin on Sat Jun 26 02:21:40 UTC 2021 , Edited by admin on Sat Jun 26 02:21:40 UTC 2021
PRIMARY
FDA UNII
M43H21IO8R
Created by admin on Sat Jun 26 02:21:40 UTC 2021 , Edited by admin on Sat Jun 26 02:21:40 UTC 2021
PRIMARY
ECHA (EC/EINECS)
200-549-8
Created by admin on Sat Jun 26 02:21:40 UTC 2021 , Edited by admin on Sat Jun 26 02:21:40 UTC 2021
PRIMARY
USP_CATALOG
1466674
Created by admin on Sat Jun 26 02:21:40 UTC 2021 , Edited by admin on Sat Jun 26 02:21:40 UTC 2021
PRIMARY USP-RS
NCI_THESAURUS
C44417
Created by admin on Sat Jun 26 02:21:40 UTC 2021 , Edited by admin on Sat Jun 26 02:21:40 UTC 2021
PRIMARY
CAS
62-75-9
Created by admin on Sat Jun 26 02:21:40 UTC 2021 , Edited by admin on Sat Jun 26 02:21:40 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> IMPURITY
NDMA is an organic chemical that is in a family of potent carcinogens.
PARENT->IMPURITY GENOTOXIC
NDMA is an organic chemical that is in a family of potent carcinogens.
PARENT->IMPURITY GENOTOXIC
NDMA is an organic chemical that is in a family of potent carcinogens.
PARENT->IMPURITY GENOTOXIC
NDMA is an organic chemical that is in a family of potent carcinogens.
PARENT->IMPURITY GENOTOXIC
NDMA is an organic chemical that is in a family of potent carcinogens.
PARENT -> IMPURITY
NDMA is an organic chemical that is in a family of potent carcinogens.
PARENT->IMPURITY GENOTOXIC
NDMA is an organic chemical that is part of a family of potent carcinogens.
PARENT->IMPURITY GENOTOXIC
NDMA is an organic chemical that is in a family of potent carcinogens.
PARENT->IMPURITY GENOTOXIC
NDMA is an organic chemical that is in a family of potent carcinogens.