N-NITROSODIMETHYLAMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H6N2O
Molecular Weight	74.0818
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)N=O

InChI

InChIKey=UMFJAHHVKNCGLG-UHFFFAOYSA-N

InChI=1S/C2H6N2O/c1-4(2)3-5/h1-2H3

HIDE SMILES / InChI

Molecular Formula	C2H6N2O
Molecular Weight	74.0818
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Promotion of chemically induced rat esophageal tumorigenesis with post-initiation ethanol modification.	2001	11406835
[Morphologic study of renal carcinogenesis in rats induced by dimethylnitrosamine].	2001	11317540
A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in rats.	2001 Apr	11394652
Changes in the expression of cytochrome P450 2E1 and the activity of carcinogen-metabolizing enzymes in Schistosoma haematobium-infected human bladder tissues.	2001 Apr 12	11311457
Attempt to adsorb N-nitrosamines in solution by use of zeolites.	2001 Aug	11513428
Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.	2001 Aug 1	11479212
The influence of very low doses of N-nitrosodimethylamine (NDMA) on the apoptosis of rat neutrophils in vivo. The role of reactive oxygen species.	2001 Aug 13	11551432
Mixture of N-carbamoyl-L-glutamate plus L-arginine can protect rats with liver cirrhosis from acute ammonia intoxication.	2001 Dec	11738098
Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells.	2001 Feb	11169066
Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen.	2001 Jan 2	11164615
2-(Allylthio)pyrazine, a cancer chemopreventive agent, inhibits liver fibrosis induced by dimethylnitrosamine in rats: role of inhibition of transforming growth factor-beta1 expression.	2001 Jul	11484906
Pirfenidone inhibits dimethylnitrosamine-induced hepatic fibrosis in rats.	2001 Jul	11422218
Effects of dietary N-(4-hydroxyphenyl)retinamide on N-nitrosomethylbenzylamine metabolism and esophageal tumorigenesis in the Fischer 344 rat.	2001 Jul 4	11438564
Importance of DNA repair in carcinogenesis: evidence from transgenic and gene targeting studies.	2001 Jun 2	11376685
Reporter gene transgenic mice as a tool for analyzing the molecular mechanisms underlying experimental carcinogenesis.	2001 Mar	11370817
Alpha-difluoromethylornithine induction of apoptosis: a mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats.	2001 Mar	11303587
Heterogeneity and plasticity of hepatocyte lineage cells.	2001 Mar	11230756
The preparation of anthraquinone used in the National Toxicology Program cancer bioassay was contaminated with the mutagen 9-nitroanthracene.	2001 Mar	11230561
Involvement of CYP2E1 and carboxylesterase enzymes in vinyl carbamate metabolism in human lung microsomes.	2001 Mar	11181492
Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population.	2001 Mar 20	11241319
Gas chromatographic-mass spectrometric determination of hydrophilic compounds in environmental water by solid-phase extraction with activated carbon fiber felt.	2001 Mar 9	11269598
Effect of cadmium and zinc-metallothionein on methemoglobin and nitric oxide in dimethylnitrosamine treated rats.	2001 May	11510137
DNA damage induced by red food dyes orally administered to pregnant and male mice.	2001 May	11294979
Induction of cytochrome P450-dependent monooxygenase in mouse liver and kidney by rutaecarpine, an alkaloid of the herbal drug Evodia rutaecarpa.	2001 Nov 30	11787945
TAC-101, a novel retinobenzoic-acid derivative, enhances gap junctional intercellular communication among renal epithelial cells treated with renal carcinogens.	2001 Nov-Dec	11911287
Esophageal cancer prevention in zinc-deficient rats: rapid induction of apoptosis by replenishing zinc.	2001 Oct 17	11604475
N-nitrososdimethylamine is activated in microsomes from hepatocytes to reactive metabolites which damage DNA of non-parenchymal cells in rat liver.	2001 Sep 15	11641050
Determination of N-nitrosodimethylamine in environmental aqueous samples by isotope-dilution GC/MS-SIM.	2001 Sep-Oct	11601460
Fast microwave-assisted dansylation of N-nitrosamines. Analysis by high-performance liquid chromatography with fluorescence detection.	2002 Feb 8	11873962
Effects of Wu-chu-yu-tang and its component herbs on drug-metabolizing enzymes.	2002 Jul	12184732
Transgenic rats carrying human c-Ha-ras proto-oncogene are highly susceptible to N-nitrosomethylbenzylamine induction of esophageal tumorigenesis.	2002 Jul	12149139
Volatile N-nitrosamine inhibition after intake Korean green tea and Maesil (Prunus mume SIEB. et ZACC.) extracts with an amine-rich diet in subjects ingesting nitrate.	2002 Jul	12065217
Rapid in vivo assay for topical oral cancer chemopreventive agents.	2002 Jul	12063563
Evidence for the presence of active cytochrome P450 systems in Schistosoma mansoni and Schistosoma haematobium adult worms.	2002 May 22	12023046
Cytochrome P450 2E1 dependent catalytic activity and lipid peroxidation in rat blood lymphocytes.	2002 Oct 11	12270756
Weak enhancing effects of simultaneous ethanol administration on chemically induced rat esophageal tumorigenesis.	2002 Sep-Oct	12168075

Patents

Substance Class	Chemical Created by `admin` on `Wed Jul 05 22:33:42 UTC 2023` Edited by `admin` on `Wed Jul 05 22:33:42 UTC 2023`
Record UNII	M43H21IO8R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

N-NITROSODIMETHYLAMINE

Systematic Name

English

DIMETHYLNITROSAMINE

Common Name

English

N-NITROSODIMETHYLAMINE [HSDB]

Common Name

English

N-NITROSODIMETHYLAMINE [USP-RS]

Common Name

English

DMN

Common Name

English

N-NITROSODIMETHYLAMINE [IARC]

Common Name

English

NDMA

Common Name

English

DMNA

Common Name

English

METHANAMINE, N-METHYL-N-NITROSO-

Systematic Name

English

NSC-23226

Code

English

NMDA (GENOTOXIC)

Common Name

English

N-NITROSODIMETHYLAMINE [MI]

Common Name

English

N-METHYL-N-NITROSOMETHANAMINE

Systematic Name

English

Classification Tree Code System Code

IARC

<i>N</i>-Nitrosodimethylamine

NCI_THESAURUS

C45398