N-NITROSODIMETHYLAMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H6N2O
Molecular Weight	74.0819
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)N=O

InChI

InChIKey=UMFJAHHVKNCGLG-UHFFFAOYSA-N

InChI=1S/C2H6N2O/c1-4(2)3-5/h1-2H3

HIDE SMILES / InChI

Molecular Formula	C2H6N2O
Molecular Weight	74.0819
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Meat consumption and risk of stomach cancer in Uruguay: a case-control study.	2001	11962244
[Clinico-experimental basis for regional and systemic administration of thiopoietins in liver cirrhosis. Report I].	2001	11837162
O6-alkylguanines, dietary N-nitroso compounds, and their precursors in gastric cancer.	2001	11588901
The influence of very low doses of N-nitrosodimethylamine (NDMA) on the apoptosis of rat neutrophils in vivo. The role of reactive oxygen species.	2001 Aug 13	11551432
Mixture of N-carbamoyl-L-glutamate plus L-arginine can protect rats with liver cirrhosis from acute ammonia intoxication.	2001 Dec	11738098
Cytochrome b(5) coexpression increases the CYP2E1-dependent mutagenicity of dialkylnitrosamines in methyltransferase-deficient strains of Salmonella typhimurium.	2001 Dec 12	11733072
Carbon tetrachloride changes the activity of cytochrome P450 system in the liver of male rats: role of antioxidants.	2001 Dec 14	11718950
Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis.	2001 Feb	11819731
Effects of octreotide on intestinal transit and bacterial translocation in conscious rats with portal hypertension and liver fibrosis.	2001 Nov	11713937
Rat oesophageal cytochrome P450 (CYP) monooxygenase system: comparison to the liver and relevance in N-nitrosodiethylamine carcinogenesis.	2001 Nov	11698352
S9 induction by the combined treatment with cyclohexanol and albendazole.	2001 Nov	11682644
Dimethyl sulfoxide inhibits dimethylnitrosamine-induced hepatic fibrosis in rats.	2001 Nov	11605027
Role of human cytochrome P450 (CYP) in the metabolic activation of N-alkylnitrosamines: application of genetically engineered Salmonella typhimurium YG7108 expressing each form of CYP together with human NADPH-cytochrome P450 reductase.	2001 Nov 1	11600130
[The role of xanthine oxidase in the cytotoxic action of nitrates and nitrites].	2001 Nov-Dec	12199068
TAC-101, a novel retinobenzoic-acid derivative, enhances gap junctional intercellular communication among renal epithelial cells treated with renal carcinogens.	2001 Nov-Dec	11911287
Assessment of chronic toxicity and carcinogenicity in an accelerated cancer bioassay in rats of moxifloxacin, a quinolone antibiotic.	2001 Oct	11817103
Cell type-specific induction of O6-alkylguanine-DNA alkyltransferase mRNA expression in rat liver during regeneration, inflammation and preneoplasia.	2001 Oct	11599795
Lack of effect of furfural on unscheduled DNA synthesis in the in vivo rat and mouse hepatocyte DNA repair assays and in precision-cut human liver slices.	2001 Oct	11524138
Esophageal cancer prevention in zinc-deficient rats: rapid induction of apoptosis by replenishing zinc.	2001 Oct 17	11604475
Incidence and effects of Ha-ras codon 12 G-->A transition mutations in preneoplastic lesions induced by N-nitrosomethylbenzylamine in the rat esophagus.	2001 Sep	11568970
Intragastric volatile N-nitrosamines, nitrite, pH, and Helicobacter pylori during long-term treatment with omeprazole.	2001 Sep	11522734
Increased oxidative stress in dimethylnitrosamine-induced liver fibrosis in the rat: effect of N-acetylcysteine and interferon-alpha.	2001 Sep 1	11543645
N-nitrososdimethylamine is activated in microsomes from hepatocytes to reactive metabolites which damage DNA of non-parenchymal cells in rat liver.	2001 Sep 15	11641050
Determination of N-nitrosodimethylamine in environmental aqueous samples by isotope-dilution GC/MS-SIM.	2001 Sep-Oct	11601460
A kinetic model of N-nitrosodimethylamine (NDMA) formation during water chlorination/chloramination.	2002	12227605
Preliminary evaluation of the cytotoxic and genotoxic potential of D-003: Mixture of very long chain fatty acids.	2002	11948628
Alcohol induction of liver nuclear ethanol and N-nitrosodimethylamine metabolism to reactive metabolites.	2002	11835291
Mechanistic studies of N-nitrosodimethylamine (NDMA) formation in chlorinated drinking water.	2002 Apr	11993764
CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.	2002 Apr	11960914
Microsome-mediated oxidation of N-nitrosodiethanolamine (NDELA), a bident carcinogen.	2002 Apr	11952331
Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer.	2002 Aug	12198369
Effects of extract derived from Eriobotrya japonica on liver function improvement in rats.	2002 Aug	12186409
Functional role of cytochrome p-450 2a3 in N-nitrosomethylbenzylamine metabolism in rat esophagus.	2002 Aug 9	12167220
Formation of N-nitrosodimethylamine (NDMA) from reaction of monochloramine: a new disinfection by-product.	2002 Feb	11848351
Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin.	2002 Feb 15	11884234
Formation of N-nitrosodimethylamine (NDMA) from dimethylamine during chlorination.	2002 Feb 15	11878371
Structure-activity relationships of several anisidine and dibenzanthracene isomers in the w/w+ somatic assay of Drosophila melanogaster.	2002 Feb 15	11815257
Fast microwave-assisted dansylation of N-nitrosamines. Analysis by high-performance liquid chromatography with fluorescence detection.	2002 Feb 8	11873962
Antimutagenic and anticarcinogenic effects of Phyllanthus amarus.	2002 Jan	11924760
Susceptibility of liver proliferative lesions in heterozygous p53 deficient CBA mice to various carcinogens.	2002 Jul	12185306
Transgenic rats carrying human c-Ha-ras proto-oncogene are highly susceptible to N-nitrosomethylbenzylamine induction of esophageal tumorigenesis.	2002 Jul	12149139
Impairment of activation of hepatocyte growth factor precursor into its mature form in rats with liver cirrhosis.	2002 Jul	12127815
Volatile N-nitrosamine inhibition after intake Korean green tea and Maesil (Prunus mume SIEB. et ZACC.) extracts with an amine-rich diet in subjects ingesting nitrate.	2002 Jul	12065217
Rapid in vivo assay for topical oral cancer chemopreventive agents.	2002 Jul	12063563
DNA adducts and liver DNA replication in rats during chronic exposure to N-nitrosodimethylamine (NDMA) and their relationships to the dose-dependence of NDMA hepatocarcinogenesis.	2002 Mar 20	11890936
Effect of ethanol treatment on metabolic activation and detoxification of esophagus carcinogenic N-nitrosamines in rat liver.	2002 May	11971997
Effect of some hypoglycemic herbs on the activity of phase I and II drug-metabolizing enzymes in alloxan-induced diabetic rats.	2002 May 24	11985890
Cytochrome P450 2E1 dependent catalytic activity and lipid peroxidation in rat blood lymphocytes.	2002 Oct 11	12270756
Monitoring of nitrite and N-nitrosamine levels in irradiated pork sausage.	2002 Sep	12233865
Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol.	2002 Sep	12189197

Patents

Substance Class	Chemical Created by `admin` on `Sat Jun 26 02:21:39 UTC 2021` Edited by `admin` on `Sat Jun 26 02:21:39 UTC 2021`
Record UNII	M43H21IO8R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

N-NITROSODIMETHYLAMINE

Systematic Name

English

DIMETHYLNITROSAMINE

Common Name

English

N-NITROSODIMETHYLAMINE [HSDB]

Common Name

English

N-NITROSODIMETHYLAMINE [USP-RS]

Common Name

English

DMN

Common Name

English

N-NITROSODIMETHYLAMINE [IARC]

Common Name

English

NDMA

Common Name

English

DMNA

Common Name

English

METHANAMINE, N-METHYL-N-NITROSO-

Systematic Name

English

NSC-23226

Code

English

NMDA (GENOTOXIC)

Common Name

English

N-NITROSODIMETHYLAMINE [MI]

Common Name

English

N-METHYL-N-NITROSOMETHANAMINE

Systematic Name

English

Classification Tree Code System Code

IARC

<i>N</i>-Nitrosodimethylamine

NCI_THESAURUS

C45398