U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C2H6N2O
Molecular Weight 74.0818
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of N-NITROSODIMETHYLAMINE

SMILES

CN(C)N=O

InChI

InChIKey=UMFJAHHVKNCGLG-UHFFFAOYSA-N
InChI=1S/C2H6N2O/c1-4(2)3-5/h1-2H3

HIDE SMILES / InChI

Molecular Formula C2H6N2O
Molecular Weight 74.0818
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Promotion of chemically induced rat esophageal tumorigenesis with post-initiation ethanol modification.
2001
[Morphologic study of renal carcinogenesis in rats induced by dimethylnitrosamine].
2001
A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in rats.
2001 Apr
Changes in the expression of cytochrome P450 2E1 and the activity of carcinogen-metabolizing enzymes in Schistosoma haematobium-infected human bladder tissues.
2001 Apr 12
Attempt to adsorb N-nitrosamines in solution by use of zeolites.
2001 Aug
Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis.
2001 Aug 1
The influence of very low doses of N-nitrosodimethylamine (NDMA) on the apoptosis of rat neutrophils in vivo. The role of reactive oxygen species.
2001 Aug 13
Mixture of N-carbamoyl-L-glutamate plus L-arginine can protect rats with liver cirrhosis from acute ammonia intoxication.
2001 Dec
Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells.
2001 Feb
Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen.
2001 Jan 2
2-(Allylthio)pyrazine, a cancer chemopreventive agent, inhibits liver fibrosis induced by dimethylnitrosamine in rats: role of inhibition of transforming growth factor-beta1 expression.
2001 Jul
Pirfenidone inhibits dimethylnitrosamine-induced hepatic fibrosis in rats.
2001 Jul
Effects of dietary N-(4-hydroxyphenyl)retinamide on N-nitrosomethylbenzylamine metabolism and esophageal tumorigenesis in the Fischer 344 rat.
2001 Jul 4
Importance of DNA repair in carcinogenesis: evidence from transgenic and gene targeting studies.
2001 Jun 2
Reporter gene transgenic mice as a tool for analyzing the molecular mechanisms underlying experimental carcinogenesis.
2001 Mar
Alpha-difluoromethylornithine induction of apoptosis: a mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats.
2001 Mar
Heterogeneity and plasticity of hepatocyte lineage cells.
2001 Mar
The preparation of anthraquinone used in the National Toxicology Program cancer bioassay was contaminated with the mutagen 9-nitroanthracene.
2001 Mar
Involvement of CYP2E1 and carboxylesterase enzymes in vinyl carbamate metabolism in human lung microsomes.
2001 Mar
Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population.
2001 Mar 20
Gas chromatographic-mass spectrometric determination of hydrophilic compounds in environmental water by solid-phase extraction with activated carbon fiber felt.
2001 Mar 9
Effect of cadmium and zinc-metallothionein on methemoglobin and nitric oxide in dimethylnitrosamine treated rats.
2001 May
DNA damage induced by red food dyes orally administered to pregnant and male mice.
2001 May
Induction of cytochrome P450-dependent monooxygenase in mouse liver and kidney by rutaecarpine, an alkaloid of the herbal drug Evodia rutaecarpa.
2001 Nov 30
TAC-101, a novel retinobenzoic-acid derivative, enhances gap junctional intercellular communication among renal epithelial cells treated with renal carcinogens.
2001 Nov-Dec
Esophageal cancer prevention in zinc-deficient rats: rapid induction of apoptosis by replenishing zinc.
2001 Oct 17
N-nitrososdimethylamine is activated in microsomes from hepatocytes to reactive metabolites which damage DNA of non-parenchymal cells in rat liver.
2001 Sep 15
Determination of N-nitrosodimethylamine in environmental aqueous samples by isotope-dilution GC/MS-SIM.
2001 Sep-Oct
Fast microwave-assisted dansylation of N-nitrosamines. Analysis by high-performance liquid chromatography with fluorescence detection.
2002 Feb 8
Effects of Wu-chu-yu-tang and its component herbs on drug-metabolizing enzymes.
2002 Jul
Transgenic rats carrying human c-Ha-ras proto-oncogene are highly susceptible to N-nitrosomethylbenzylamine induction of esophageal tumorigenesis.
2002 Jul
Volatile N-nitrosamine inhibition after intake Korean green tea and Maesil (Prunus mume SIEB. et ZACC.) extracts with an amine-rich diet in subjects ingesting nitrate.
2002 Jul
Rapid in vivo assay for topical oral cancer chemopreventive agents.
2002 Jul
Evidence for the presence of active cytochrome P450 systems in Schistosoma mansoni and Schistosoma haematobium adult worms.
2002 May 22
Cytochrome P450 2E1 dependent catalytic activity and lipid peroxidation in rat blood lymphocytes.
2002 Oct 11
Weak enhancing effects of simultaneous ethanol administration on chemically induced rat esophageal tumorigenesis.
2002 Sep-Oct
Patents

Patents

Substance Class Chemical
Created
by admin
on Wed Jul 05 22:33:42 UTC 2023
Edited
by admin
on Wed Jul 05 22:33:42 UTC 2023
Record UNII
M43H21IO8R
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
N-NITROSODIMETHYLAMINE
HSDB   MI  
Systematic Name English
DIMETHYLNITROSAMINE
Common Name English
N-NITROSODIMETHYLAMINE [HSDB]
Common Name English
N-NITROSODIMETHYLAMINE [USP-RS]
Common Name English
DMN
Common Name English
N-NITROSODIMETHYLAMINE [IARC]
Common Name English
NDMA
Common Name English
DMNA
Common Name English
METHANAMINE, N-METHYL-N-NITROSO-
Systematic Name English
NSC-23226
Code English
NMDA (GENOTOXIC)
Common Name English
N-NITROSODIMETHYLAMINE [MI]
Common Name English
N-METHYL-N-NITROSOMETHANAMINE
Systematic Name English
Classification Tree Code System Code
IARC <i>N</i>-Nitrosodimethylamine
NCI_THESAURUS C45398
Created by admin on Wed Jul 05 22:33:42 UTC 2023 , Edited by admin on Wed Jul 05 22:33:42 UTC 2023
Code System Code Type Description
MERCK INDEX
M7994
Created by admin on Wed Jul 05 22:33:42 UTC 2023 , Edited by admin on Wed Jul 05 22:33:42 UTC 2023
PRIMARY Merck Index
CHEBI
59990
Created by admin on Wed Jul 05 22:33:42 UTC 2023 , Edited by admin on Wed Jul 05 22:33:42 UTC 2023
PRIMARY
WIKIPEDIA
N-NITROSODIMETHYLAMINE
Created by admin on Wed Jul 05 22:33:42 UTC 2023 , Edited by admin on Wed Jul 05 22:33:42 UTC 2023
PRIMARY
RS_ITEM_NUM
1466674
Created by admin on Wed Jul 05 22:33:42 UTC 2023 , Edited by admin on Wed Jul 05 22:33:42 UTC 2023
PRIMARY
HSDB
1667
Created by admin on Wed Jul 05 22:33:42 UTC 2023 , Edited by admin on Wed Jul 05 22:33:42 UTC 2023
PRIMARY
EPA CompTox
DTXSID7021029
Created by admin on Wed Jul 05 22:33:42 UTC 2023 , Edited by admin on Wed Jul 05 22:33:42 UTC 2023
PRIMARY
MESH
D004128
Created by admin on Wed Jul 05 22:33:42 UTC 2023 , Edited by admin on Wed Jul 05 22:33:42 UTC 2023
PRIMARY
PUBCHEM
6124
Created by admin on Wed Jul 05 22:33:42 UTC 2023 , Edited by admin on Wed Jul 05 22:33:42 UTC 2023
PRIMARY
FDA UNII
M43H21IO8R
Created by admin on Wed Jul 05 22:33:42 UTC 2023 , Edited by admin on Wed Jul 05 22:33:42 UTC 2023
PRIMARY
CHEBI
35807
Created by admin on Wed Jul 05 22:33:42 UTC 2023 , Edited by admin on Wed Jul 05 22:33:42 UTC 2023
PRIMARY
ECHA (EC/EINECS)
200-549-8
Created by admin on Wed Jul 05 22:33:42 UTC 2023 , Edited by admin on Wed Jul 05 22:33:42 UTC 2023
PRIMARY
NSC
23226
Created by admin on Wed Jul 05 22:33:42 UTC 2023 , Edited by admin on Wed Jul 05 22:33:42 UTC 2023
PRIMARY
SMS_ID
100000183957
Created by admin on Wed Jul 05 22:33:42 UTC 2023 , Edited by admin on Wed Jul 05 22:33:42 UTC 2023
PRIMARY
NCI_THESAURUS
C44417
Created by admin on Wed Jul 05 22:33:42 UTC 2023 , Edited by admin on Wed Jul 05 22:33:42 UTC 2023
PRIMARY
CAS
62-75-9
Created by admin on Wed Jul 05 22:33:42 UTC 2023 , Edited by admin on Wed Jul 05 22:33:42 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> IMPURITY
NDMA is an organic chemical that is in a family of potent carcinogens.
PARENT->IMPURITY GENOTOXIC
NDMA is an organic chemical that is in a family of potent carcinogens.
PARENT->IMPURITY GENOTOXIC
NDMA is an organic chemical that is in a family of potent carcinogens.
PARENT->IMPURITY GENOTOXIC
NDMA is an organic chemical that is in a family of potent carcinogens.
PARENT->IMPURITY GENOTOXIC
NDMA is an organic chemical that is in a family of potent carcinogens.
PARENT -> IMPURITY
NDMA is an organic chemical that is in a family of potent carcinogens.
PARENT->IMPURITY GENOTOXIC
NDMA is an organic chemical that is part of a family of potent carcinogens.
PARENT->IMPURITY GENOTOXIC
NDMA is an organic chemical that is in a family of potent carcinogens.
PARENT->IMPURITY GENOTOXIC
NDMA is an organic chemical that is in a family of potent carcinogens.