N-Nitrosodimethylamine

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H6N2O
Molecular Weight	74.0818
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)N=O

InChI

InChIKey=UMFJAHHVKNCGLG-UHFFFAOYSA-N

InChI=1S/C2H6N2O/c1-4(2)3-5/h1-2H3

HIDE SMILES / InChI

Molecular Formula	C2H6N2O
Molecular Weight	74.0818
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Meat consumption and risk of stomach cancer in Uruguay: a case-control study.	2001	11962244
[Clinico-experimental basis for regional and systemic administration of thiopoietins in liver cirrhosis. Report I].	2001	11837162
[N-nitrosodimethylamine--toxicologic significance].	2001	11468977
Chromosome analysis of human spermatozoa following in vitro exposure to cyclophosphamide, benzo(a)pyrene and N-nitrosodimethylamine in the presence of rat liver S9.	2001 Apr 5	11287298
Carbon tetrachloride changes the activity of cytochrome P450 system in the liver of male rats: role of antioxidants.	2001 Dec 14	11718950
Monitoring airborne genotoxicants in the rubber industry using genotoxicity tests and chemical analyses.	2001 Feb 20	11342241
Carcinogenicity assays of wood dust and wood additives in rats exposed by long-term inhalation.	2001 Mar	11317703
Alpha-difluoromethylornithine induction of apoptosis: a mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats.	2001 Mar	11303587
Inhibition of N-nitrosomethylbenzylamine-induced tumorigenesis in the rat esophagus by dietary freeze-dried strawberries.	2001 Mar	11238184
Heterogeneity and plasticity of hepatocyte lineage cells.	2001 Mar	11230756
The preparation of anthraquinone used in the National Toxicology Program cancer bioassay was contaminated with the mutagen 9-nitroanthracene.	2001 Mar	11230561
Gas chromatographic-mass spectrometric determination of hydrophilic compounds in environmental water by solid-phase extraction with activated carbon fiber felt.	2001 Mar 9	11269598
Effects of octreotide on intestinal transit and bacterial translocation in conscious rats with portal hypertension and liver fibrosis.	2001 Nov	11713937
Rat oesophageal cytochrome P450 (CYP) monooxygenase system: comparison to the liver and relevance in N-nitrosodiethylamine carcinogenesis.	2001 Nov	11698352
S9 induction by the combined treatment with cyclohexanol and albendazole.	2001 Nov	11682644
Dimethyl sulfoxide inhibits dimethylnitrosamine-induced hepatic fibrosis in rats.	2001 Nov	11605027
TAC-101, a novel retinobenzoic-acid derivative, enhances gap junctional intercellular communication among renal epithelial cells treated with renal carcinogens.	2001 Nov-Dec	11911287
N-nitrososdimethylamine is activated in microsomes from hepatocytes to reactive metabolites which damage DNA of non-parenchymal cells in rat liver.	2001 Sep 15	11641050
Preliminary evaluation of the cytotoxic and genotoxic potential of D-003: Mixture of very long chain fatty acids.	2002	11948628
Mechanistic studies of N-nitrosodimethylamine (NDMA) formation in chlorinated drinking water.	2002 Apr	11993764
CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.	2002 Apr	11960914
Microsome-mediated oxidation of N-nitrosodiethanolamine (NDELA), a bident carcinogen.	2002 Apr	11952331
Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin.	2002 Feb 15	11884234
Structure-activity relationships of several anisidine and dibenzanthracene isomers in the w/w+ somatic assay of Drosophila melanogaster.	2002 Feb 15	11815257
Antimutagenic and anticarcinogenic effects of Phyllanthus amarus.	2002 Jan	11924760
DNA adducts and liver DNA replication in rats during chronic exposure to N-nitrosodimethylamine (NDMA) and their relationships to the dose-dependence of NDMA hepatocarcinogenesis.	2002 Mar 20	11890936
Effect of ethanol treatment on metabolic activation and detoxification of esophagus carcinogenic N-nitrosamines in rat liver.	2002 May	11971997
Effect of some hypoglycemic herbs on the activity of phase I and II drug-metabolizing enzymes in alloxan-induced diabetic rats.	2002 May 24	11985890

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:35:45 GMT 2025` Edited by `admin` on `Mon Mar 31 17:35:45 GMT 2025`
Record UNII	M43H21IO8R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NSC-23226

Preferred Name

English

N-Nitrosodimethylamine

Systematic Name

English

Dimethylnitrosamine

Common Name

English

N-Nitrosodimethylamine [HSDB]

Common Name

English

N-Nitrosodimethylamine [USP-RS]

Common Name

English

DMN

Common Name

English

N-Nitrosodimethylamine [IARC]

Common Name

English

NDMA

Common Name

English

DMNA

Common Name

English

Methanamine, N-methyl-N-nitroso-

Systematic Name

English

NMDA (GENOTOXIC)

Common Name

English

N-Nitrosodimethylamine [MI]

Common Name

English

N-Methyl-N-nitrosomethanamine

Systematic Name

English

Classification Tree Code System Code

IARC

<i>N</i>-Nitrosodimethylamine

NCI_THESAURUS

C45398