N-NITROSODIMETHYLAMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H6N2O
Molecular Weight	74.0818
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)N=O

InChI

InChIKey=UMFJAHHVKNCGLG-UHFFFAOYSA-N

InChI=1S/C2H6N2O/c1-4(2)3-5/h1-2H3

HIDE SMILES / InChI

Molecular Formula	C2H6N2O
Molecular Weight	74.0818
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Meat consumption and risk of stomach cancer in Uruguay: a case-control study.	2001	11962244
[Clinico-experimental basis for regional and systemic administration of thiopoietins in liver cirrhosis. Report I].	2001	11837162
[N-nitrosodimethylamine--toxicologic significance].	2001	11468977
Promotion of chemically induced rat esophageal tumorigenesis with post-initiation ethanol modification.	2001	11406835
A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in rats.	2001 Apr	11394652
Attempt to adsorb N-nitrosamines in solution by use of zeolites.	2001 Aug	11513428
Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries.	2001 Aug 15	11507061
Release of nitric oxide together with carbon-centered radicals from N-nitrosamines by ultraviolet light irradiation.	2001 Dec	11811531
Inhibition of the NA(+)/H(+) exchanger reduces rat hepatic stellate cell activity and liver fibrosis: an in vitro and in vivo study.	2001 Feb	11159895
Monitoring airborne genotoxicants in the rubber industry using genotoxicity tests and chemical analyses.	2001 Feb 20	11342241
Investigation of the enhancement of N-nitrosomethylbenzylamine-induced esophageal tumorigenesis by 6-phenylhexyl isothiocyanate.	2001 Jan 10	11121858
Pirfenidone inhibits dimethylnitrosamine-induced hepatic fibrosis in rats.	2001 Jul	11422218
Effects of dietary N-(4-hydroxyphenyl)retinamide on N-nitrosomethylbenzylamine metabolism and esophageal tumorigenesis in the Fischer 344 rat.	2001 Jul 4	11438564
Determination of N-nitrosodimethylamine in artificial gastric juice by gas chromatography-mass spectrometry and by gas chromatography-thermal energy analysis.	2001 Jun	11432714
Importance of DNA repair in carcinogenesis: evidence from transgenic and gene targeting studies.	2001 Jun 2	11376685
Alpha-difluoromethylornithine induction of apoptosis: a mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats.	2001 Mar	11303587
Inhibition of N-nitrosomethylbenzylamine-induced tumorigenesis in the rat esophagus by dietary freeze-dried strawberries.	2001 Mar	11238184
Heterogeneity and plasticity of hepatocyte lineage cells.	2001 Mar	11230756
Effects of octreotide on intestinal transit and bacterial translocation in conscious rats with portal hypertension and liver fibrosis.	2001 Nov	11713937
Rat oesophageal cytochrome P450 (CYP) monooxygenase system: comparison to the liver and relevance in N-nitrosodiethylamine carcinogenesis.	2001 Nov	11698352
Dimethyl sulfoxide inhibits dimethylnitrosamine-induced hepatic fibrosis in rats.	2001 Nov	11605027
[The role of xanthine oxidase in the cytotoxic action of nitrates and nitrites].	2001 Nov-Dec	12199068
TAC-101, a novel retinobenzoic-acid derivative, enhances gap junctional intercellular communication among renal epithelial cells treated with renal carcinogens.	2001 Nov-Dec	11911287
Assessment of chronic toxicity and carcinogenicity in an accelerated cancer bioassay in rats of moxifloxacin, a quinolone antibiotic.	2001 Oct	11817103
Incidence and effects of Ha-ras codon 12 G-->A transition mutations in preneoplastic lesions induced by N-nitrosomethylbenzylamine in the rat esophagus.	2001 Sep	11568970
Intragastric volatile N-nitrosamines, nitrite, pH, and Helicobacter pylori during long-term treatment with omeprazole.	2001 Sep	11522734
Increased oxidative stress in dimethylnitrosamine-induced liver fibrosis in the rat: effect of N-acetylcysteine and interferon-alpha.	2001 Sep 1	11543645
A kinetic model of N-nitrosodimethylamine (NDMA) formation during water chlorination/chloramination.	2002	12227605
Preliminary evaluation of the cytotoxic and genotoxic potential of D-003: Mixture of very long chain fatty acids.	2002	11948628
Alcohol induction of liver nuclear ethanol and N-nitrosodimethylamine metabolism to reactive metabolites.	2002	11835291
CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.	2002 Apr	11960914
Effects of extract derived from Eriobotrya japonica on liver function improvement in rats.	2002 Aug	12186409
Inhibitory effect of whole strawberries, garlic juice or kale juice on endogenous formation of N-nitrosodimethylamine in humans.	2002 Aug 8	12175517
Formation of N-nitrosodimethylamine (NDMA) from reaction of monochloramine: a new disinfection by-product.	2002 Feb	11848351
Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin.	2002 Feb 15	11884234
Fast microwave-assisted dansylation of N-nitrosamines. Analysis by high-performance liquid chromatography with fluorescence detection.	2002 Feb 8	11873962
Susceptibility of liver proliferative lesions in heterozygous p53 deficient CBA mice to various carcinogens.	2002 Jul	12185306
Effects of Wu-chu-yu-tang and its component herbs on drug-metabolizing enzymes.	2002 Jul	12184732
Impairment of activation of hepatocyte growth factor precursor into its mature form in rats with liver cirrhosis.	2002 Jul	12127815
Volatile N-nitrosamine inhibition after intake Korean green tea and Maesil (Prunus mume SIEB. et ZACC.) extracts with an amine-rich diet in subjects ingesting nitrate.	2002 Jul	12065217
Rapid in vivo assay for topical oral cancer chemopreventive agents.	2002 Jul	12063563
Radiation- and chemical-induced structural chromosome aberrations in human spermatozoa.	2002 Jul 25	12106658
Pathogenic roles of tumor necrosis factor receptor p55-mediated signals in dimethylnitrosamine-induced murine liver fibrosis.	2002 May	12003998
Evidence for the presence of active cytochrome P450 systems in Schistosoma mansoni and Schistosoma haematobium adult worms.	2002 May 22	12023046
Effect of some hypoglycemic herbs on the activity of phase I and II drug-metabolizing enzymes in alloxan-induced diabetic rats.	2002 May 24	11985890
Cytochrome P450 2E1 dependent catalytic activity and lipid peroxidation in rat blood lymphocytes.	2002 Oct 11	12270756
Monitoring of nitrite and N-nitrosamine levels in irradiated pork sausage.	2002 Sep	12233865
Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol.	2002 Sep	12189197
Weak enhancing effects of simultaneous ethanol administration on chemically induced rat esophageal tumorigenesis.	2002 Sep-Oct	12168075

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:01:38 GMT 2023` Edited by `admin` on `Fri Dec 15 15:01:38 GMT 2023`
Record UNII	M43H21IO8R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

N-NITROSODIMETHYLAMINE

Systematic Name

English

DIMETHYLNITROSAMINE

Common Name

English

N-NITROSODIMETHYLAMINE [HSDB]

Common Name

English

N-NITROSODIMETHYLAMINE [USP-RS]

Common Name

English

DMN

Common Name

English

N-NITROSODIMETHYLAMINE [IARC]

Common Name

English

NDMA

Common Name

English

DMNA

Common Name

English

METHANAMINE, N-METHYL-N-NITROSO-

Systematic Name

English

NSC-23226

Code

English

NMDA (GENOTOXIC)

Common Name

English

N-NITROSODIMETHYLAMINE [MI]

Common Name

English

N-METHYL-N-NITROSOMETHANAMINE

Systematic Name

English

Classification Tree Code System Code

IARC

<i>N</i>-Nitrosodimethylamine

NCI_THESAURUS

C45398