Details
Stereochemistry | ACHIRAL |
Molecular Formula | C2H6N2O |
Molecular Weight | 74.0819 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)N=O
InChI
InChIKey=UMFJAHHVKNCGLG-UHFFFAOYSA-N
InChI=1S/C2H6N2O/c1-4(2)3-5/h1-2H3
Molecular Formula | C2H6N2O |
Molecular Weight | 74.0819 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
PubMed
Title | Date | PubMed |
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Meat consumption and risk of stomach cancer in Uruguay: a case-control study. | 2001 |
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[Clinico-experimental basis for regional and systemic administration of thiopoietins in liver cirrhosis. Report I]. | 2001 |
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O6-alkylguanines, dietary N-nitroso compounds, and their precursors in gastric cancer. | 2001 |
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The influence of very low doses of N-nitrosodimethylamine (NDMA) on the apoptosis of rat neutrophils in vivo. The role of reactive oxygen species. | 2001 Aug 13 |
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Mixture of N-carbamoyl-L-glutamate plus L-arginine can protect rats with liver cirrhosis from acute ammonia intoxication. | 2001 Dec |
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Cytochrome b(5) coexpression increases the CYP2E1-dependent mutagenicity of dialkylnitrosamines in methyltransferase-deficient strains of Salmonella typhimurium. | 2001 Dec 12 |
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Carbon tetrachloride changes the activity of cytochrome P450 system in the liver of male rats: role of antioxidants. | 2001 Dec 14 |
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Animal experiment and clinical study of effect of gamma-interferon on hepatic fibrosis. | 2001 Feb |
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Effects of octreotide on intestinal transit and bacterial translocation in conscious rats with portal hypertension and liver fibrosis. | 2001 Nov |
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Rat oesophageal cytochrome P450 (CYP) monooxygenase system: comparison to the liver and relevance in N-nitrosodiethylamine carcinogenesis. | 2001 Nov |
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S9 induction by the combined treatment with cyclohexanol and albendazole. | 2001 Nov |
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Dimethyl sulfoxide inhibits dimethylnitrosamine-induced hepatic fibrosis in rats. | 2001 Nov |
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Role of human cytochrome P450 (CYP) in the metabolic activation of N-alkylnitrosamines: application of genetically engineered Salmonella typhimurium YG7108 expressing each form of CYP together with human NADPH-cytochrome P450 reductase. | 2001 Nov 1 |
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[The role of xanthine oxidase in the cytotoxic action of nitrates and nitrites]. | 2001 Nov-Dec |
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TAC-101, a novel retinobenzoic-acid derivative, enhances gap junctional intercellular communication among renal epithelial cells treated with renal carcinogens. | 2001 Nov-Dec |
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Assessment of chronic toxicity and carcinogenicity in an accelerated cancer bioassay in rats of moxifloxacin, a quinolone antibiotic. | 2001 Oct |
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Cell type-specific induction of O6-alkylguanine-DNA alkyltransferase mRNA expression in rat liver during regeneration, inflammation and preneoplasia. | 2001 Oct |
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Lack of effect of furfural on unscheduled DNA synthesis in the in vivo rat and mouse hepatocyte DNA repair assays and in precision-cut human liver slices. | 2001 Oct |
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Esophageal cancer prevention in zinc-deficient rats: rapid induction of apoptosis by replenishing zinc. | 2001 Oct 17 |
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Incidence and effects of Ha-ras codon 12 G-->A transition mutations in preneoplastic lesions induced by N-nitrosomethylbenzylamine in the rat esophagus. | 2001 Sep |
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Intragastric volatile N-nitrosamines, nitrite, pH, and Helicobacter pylori during long-term treatment with omeprazole. | 2001 Sep |
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Increased oxidative stress in dimethylnitrosamine-induced liver fibrosis in the rat: effect of N-acetylcysteine and interferon-alpha. | 2001 Sep 1 |
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N-nitrososdimethylamine is activated in microsomes from hepatocytes to reactive metabolites which damage DNA of non-parenchymal cells in rat liver. | 2001 Sep 15 |
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Determination of N-nitrosodimethylamine in environmental aqueous samples by isotope-dilution GC/MS-SIM. | 2001 Sep-Oct |
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A kinetic model of N-nitrosodimethylamine (NDMA) formation during water chlorination/chloramination. | 2002 |
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Preliminary evaluation of the cytotoxic and genotoxic potential of D-003: Mixture of very long chain fatty acids. | 2002 |
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Alcohol induction of liver nuclear ethanol and N-nitrosodimethylamine metabolism to reactive metabolites. | 2002 |
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Mechanistic studies of N-nitrosodimethylamine (NDMA) formation in chlorinated drinking water. | 2002 Apr |
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CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism. | 2002 Apr |
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Microsome-mediated oxidation of N-nitrosodiethanolamine (NDELA), a bident carcinogen. | 2002 Apr |
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Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer. | 2002 Aug |
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Effects of extract derived from Eriobotrya japonica on liver function improvement in rats. | 2002 Aug |
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Functional role of cytochrome p-450 2a3 in N-nitrosomethylbenzylamine metabolism in rat esophagus. | 2002 Aug 9 |
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Formation of N-nitrosodimethylamine (NDMA) from reaction of monochloramine: a new disinfection by-product. | 2002 Feb |
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Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin. | 2002 Feb 15 |
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Formation of N-nitrosodimethylamine (NDMA) from dimethylamine during chlorination. | 2002 Feb 15 |
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Structure-activity relationships of several anisidine and dibenzanthracene isomers in the w/w+ somatic assay of Drosophila melanogaster. | 2002 Feb 15 |
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Fast microwave-assisted dansylation of N-nitrosamines. Analysis by high-performance liquid chromatography with fluorescence detection. | 2002 Feb 8 |
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Antimutagenic and anticarcinogenic effects of Phyllanthus amarus. | 2002 Jan |
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Susceptibility of liver proliferative lesions in heterozygous p53 deficient CBA mice to various carcinogens. | 2002 Jul |
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Transgenic rats carrying human c-Ha-ras proto-oncogene are highly susceptible to N-nitrosomethylbenzylamine induction of esophageal tumorigenesis. | 2002 Jul |
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Impairment of activation of hepatocyte growth factor precursor into its mature form in rats with liver cirrhosis. | 2002 Jul |
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Volatile N-nitrosamine inhibition after intake Korean green tea and Maesil (Prunus mume SIEB. et ZACC.) extracts with an amine-rich diet in subjects ingesting nitrate. | 2002 Jul |
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Rapid in vivo assay for topical oral cancer chemopreventive agents. | 2002 Jul |
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DNA adducts and liver DNA replication in rats during chronic exposure to N-nitrosodimethylamine (NDMA) and their relationships to the dose-dependence of NDMA hepatocarcinogenesis. | 2002 Mar 20 |
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Effect of ethanol treatment on metabolic activation and detoxification of esophagus carcinogenic N-nitrosamines in rat liver. | 2002 May |
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Effect of some hypoglycemic herbs on the activity of phase I and II drug-metabolizing enzymes in alloxan-induced diabetic rats. | 2002 May 24 |
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Cytochrome P450 2E1 dependent catalytic activity and lipid peroxidation in rat blood lymphocytes. | 2002 Oct 11 |
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Monitoring of nitrite and N-nitrosamine levels in irradiated pork sausage. | 2002 Sep |
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Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol. | 2002 Sep |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Jun 26 02:21:39 UTC 2021
by
admin
on
Sat Jun 26 02:21:39 UTC 2021
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Record UNII |
M43H21IO8R
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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IARC | <i>N</i>-Nitrosodimethylamine | ||
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NCI_THESAURUS |
C45398
Created by
admin on Sat Jun 26 02:21:40 UTC 2021 , Edited by admin on Sat Jun 26 02:21:40 UTC 2021
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Code System | Code | Type | Description | ||
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M7994
Created by
admin on Sat Jun 26 02:21:40 UTC 2021 , Edited by admin on Sat Jun 26 02:21:40 UTC 2021
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PRIMARY | Merck Index | ||
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N-NITROSODIMETHYLAMINE
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1667
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62-75-9
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D004128
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6124
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M43H21IO8R
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200-549-8
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1466674
Created by
admin on Sat Jun 26 02:21:40 UTC 2021 , Edited by admin on Sat Jun 26 02:21:40 UTC 2021
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PRIMARY | USP-RS | ||
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C44417
Created by
admin on Sat Jun 26 02:21:40 UTC 2021 , Edited by admin on Sat Jun 26 02:21:40 UTC 2021
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62-75-9
Created by
admin on Sat Jun 26 02:21:40 UTC 2021 , Edited by admin on Sat Jun 26 02:21:40 UTC 2021
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PRIMARY |
Related Record | Type | Details | ||
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PARENT -> IMPURITY |
NDMA is an organic chemical that is in a family of potent carcinogens.
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||
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PARENT->IMPURITY GENOTOXIC |
NDMA is an organic chemical that is in a family of potent carcinogens.
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||
|
PARENT->IMPURITY GENOTOXIC |
NDMA is an organic chemical that is in a family of potent carcinogens.
|
||
|
PARENT->IMPURITY GENOTOXIC |
NDMA is an organic chemical that is in a family of potent carcinogens.
|
||
|
PARENT->IMPURITY GENOTOXIC |
NDMA is an organic chemical that is in a family of potent carcinogens.
|
||
|
PARENT -> IMPURITY |
NDMA is an organic chemical that is in a family of potent carcinogens.
|
||
|
PARENT->IMPURITY GENOTOXIC |
NDMA is an organic chemical that is part of a family of potent carcinogens.
|
||
|
PARENT->IMPURITY GENOTOXIC |
NDMA is an organic chemical that is in a family of potent carcinogens.
|
||
|
PARENT->IMPURITY GENOTOXIC |
NDMA is an organic chemical that is in a family of potent carcinogens.
|