U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula 2Al.O.O4Si
Molecular Weight 162.0456
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ALUMINUM SILICATE

SMILES

[O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-]

InChI

InChIKey=YKTSYUJCYHOUJP-UHFFFAOYSA-N
InChI=1S/2Al.O4Si.O/c;;1-5(2,3)4;/q2*+3;-4;-2

HIDE SMILES / InChI
Aluminium silicate is a compound made from aluminum, oxygen and silicate that can take the form of a mineral as well as combine with water to make a clay. Aluminum silicate comes in three mineral forms: andalusite, kyanite and sillimanite, all of which have the chemical formula Al2SiO5 but have distinct crystal structures. When magnesium aluminum silicate is hydrated it becomes a clay known as kaolin, which is used for treating ailments such as diarrhea and to combat diaper rash as well as rashes from poison oak and poison ivy. When combined with magnesium and hydrated, the result is a clay mixture that sees common use in antacids as well as a thickener for cosmetics and other beauty products. It also appears as an inactive ingredient for deodorants. The kyanite form of aluminium silicate is used to create mullite for industrial use, and this compound is used by the ceramics industry as a refractory, as well as to manufacture electrical insulating materials and heating elements. Aluminium silicate (aluminum oxide silicate), under the brand name Adsorbin among others, is used as antidiarrheal agent and intestinal adsorbent. Kaolin (hydrated aluminum silicate) has traditionally been used internally to control diarrhea. Kaolin has also been used topically as an emollient and drying agent. Specifically, it has been used to dry oozing and weeping poison ivy, poison oak, and poison sumac rashes. It has also been used as a protectant for the temporary relief of anorectal itching and diaper rash.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
PLENDIL 451

Approved Use

Plendil is used in the treatment of high blood pressure; raynaud's syndrome; angina pectoris prophylaxis and belongs to the drug class calcium channel blocking agents. Risk cannot be ruled out during pregnancy.

Launch Date

1991
PubMed

PubMed

TitleDatePubMed
Relationships among the cerebral amyloid peptides and their precursors.
1989
COPD: a dust-induced disease?
2005 Oct
Element-based prognostics of occupational pneumoconiosis using micro-proton-induced X-ray emission analysis.
2017 Dec 1
Patents

Sample Use Guides

Diarrhea: 12 years of age and older: 26.2 g after each loose stool every 6 hours until firm stool; do not exceed more than 262 g per 24 hours; do not use longer than 2 days.
Route of Administration: Oral
Name Type Language
ALUMINUM SILICATE
II   INCI   MI  
INCI  
Official Name English
SILICIC ACID (H6SIO5), ALUMINUM SALT (1:2)
Common Name English
ALUMINUM SILICATE [INCI]
Common Name English
INS-559
Code English
Aluminium silicate [WHO-DD]
Common Name English
ALUMINUM SILICATE [II]
Common Name English
INS NO.559
Code English
ALUMINUM OXIDE SILICATE
Common Name English
ALUMINIUM OXIDE SILICATE
Common Name English
ALUMINUM SILICATE, NATURAL [JAN]
Common Name English
ALUMINIUM SILICATE
WHO-DD  
Common Name English
E-559
Code English
ALUMINUM OXIDE SILICATE (AL2O(SIO4))
Systematic Name English
ALUMINUM SILICATE [MI]
Common Name English
KAOLIN, LIGHT OR HEAVY
Common Name English
Classification Tree Code System Code
CFR 21 CFR 176.170
Created by admin on Fri Dec 15 15:34:39 GMT 2023 , Edited by admin on Fri Dec 15 15:34:39 GMT 2023
JECFA EVALUATION INS-559
Created by admin on Fri Dec 15 15:34:39 GMT 2023 , Edited by admin on Fri Dec 15 15:34:39 GMT 2023
CODEX ALIMENTARIUS (GSFA) INS-559
Created by admin on Fri Dec 15 15:34:39 GMT 2023 , Edited by admin on Fri Dec 15 15:34:39 GMT 2023
Code System Code Type Description
SMS_ID
100000077681
Created by admin on Fri Dec 15 15:34:39 GMT 2023 , Edited by admin on Fri Dec 15 15:34:39 GMT 2023
PRIMARY
EVMPD
SUB12836MIG
Created by admin on Fri Dec 15 15:34:39 GMT 2023 , Edited by admin on Fri Dec 15 15:34:39 GMT 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 15:34:39 GMT 2023 , Edited by admin on Fri Dec 15 15:34:39 GMT 2023
CONCEPT Industrial Aid
DAILYMED
T1FAD4SS2M
Created by admin on Fri Dec 15 15:34:39 GMT 2023 , Edited by admin on Fri Dec 15 15:34:39 GMT 2023
PRIMARY
MERCK INDEX
m1626
Created by admin on Fri Dec 15 15:34:39 GMT 2023 , Edited by admin on Fri Dec 15 15:34:39 GMT 2023
PRIMARY Merck Index
NCI_THESAURUS
C80915
Created by admin on Fri Dec 15 15:34:39 GMT 2023 , Edited by admin on Fri Dec 15 15:34:39 GMT 2023
PRIMARY
PUBCHEM
138394506
Created by admin on Fri Dec 15 15:34:39 GMT 2023 , Edited by admin on Fri Dec 15 15:34:39 GMT 2023
PRIMARY
RXCUI
1362917
Created by admin on Fri Dec 15 15:34:39 GMT 2023 , Edited by admin on Fri Dec 15 15:34:39 GMT 2023
PRIMARY RxNorm
FDA UNII
T1FAD4SS2M
Created by admin on Fri Dec 15 15:34:39 GMT 2023 , Edited by admin on Fri Dec 15 15:34:39 GMT 2023
PRIMARY
ChEMBL
CHEMBL2109020
Created by admin on Fri Dec 15 15:34:39 GMT 2023 , Edited by admin on Fri Dec 15 15:34:39 GMT 2023
PRIMARY
WIKIPEDIA
Aluminium silicate
Created by admin on Fri Dec 15 15:34:39 GMT 2023 , Edited by admin on Fri Dec 15 15:34:39 GMT 2023
PRIMARY
ECHA (EC/EINECS)
235-253-8
Created by admin on Fri Dec 15 15:34:39 GMT 2023 , Edited by admin on Fri Dec 15 15:34:39 GMT 2023
PRIMARY
CAS
12141-46-7
Created by admin on Fri Dec 15 15:34:39 GMT 2023 , Edited by admin on Fri Dec 15 15:34:39 GMT 2023
PRIMARY