Formaldehyde

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	CH2O
Molecular Weight	30.026
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C=O

InChI

InChIKey=WSFSSNUMVMOOMR-UHFFFAOYSA-N

InChI=1S/CH2O/c1-2/h1H2

HIDE SMILES / InChI

Description
Sources: https://www.drugbank.ca/drugs/DB03843
Curator's Comment: description was created based on several sources, including https://www.nap.edu/read/13142/chapter/6 | https://www.drugs.com/pro/formaldehyde-liquid.html

Formaldehyde is a naturally occurring organic compound, and an important industrial precursor to many other materials and organic compounds. Formaldehyde solution (formalin) is used as a disinfectant. Formaldehyde vapors are toxic, upon entry formaldehyde reacts readily with macromolecules, including DNA to form DNA-protein and DNA-DNA cross-links.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
DNA 278 Target ID: CHEMBL2311221 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3796657	Crosslinking Agent 81

Conditions

Condition	Modality	Targets	Highest Phase	Product
Warts 9 Sources: https://www.drugs.com/pro/formaldehyde-liquid.html	Curative		Approved 8429	FORMALDEHYDE 10% Approved Use Drying agent for pre and post surgical removal of warts, or for non-surgical laser treatment of warts where dryness is required. Safeguards against offensive odor and dries excessive moisture of feet. Not to be used in patients known to be sensitive to any of the ingredients in this product.

PubMed

Title	Date	PubMed
NAD-linked, factor-dependent formaldehyde dehydrogenase or trimeric, zinc-containing, long-chain alcohol dehydrogenase from Amycolatopsis methanolica.	1992 Jun 1	1597190
The involvement of K+ channels and Gi/o protein in the antinociceptive action of the gallic acid ethyl ester.	1999 Aug 20	10499367
Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice.	1999 Dec	10602329
Antinociceptive properties of the methanolic extract and two triterpenes isolated from Epidendrum Mosenii stems (Orchidaceae).	2000 Jan 21	10698354
Occupational asthma due to formaldehyde.	2001 Aug	11519088
Endodontic treatment of permanent teeth in children with a new calcium-carbamide-formaldehyde paste.	2002	12751685
Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain.	2003 Apr	12595749
Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat.	2003 Oct	12857938
Combined effects of tumor promoters and serum on proliferin mRNA induction: a biomarker sensitive to saccharin, 2,3,7,8-TCDD, and other compounds at minimal concentrations promoting C3H/10T1/2 cell transformation.	2003 Oct 24	14514435
Antinociceptive profile of (-)-spectaline: a piperidine alkaloid from Cassia leptophylla.	2003 Sep	14598202
Multiple formaldehyde oxidation/detoxification pathways in Burkholderia fungorum LB400.	2004 Apr	15028703
Differential immunogenic and neurogenic inflammatory responses in an allergic mouse model exposed to low levels of formaldehyde.	2004 Apr 1	15003329
GABAA receptor partially mediated propofol-induced hyperalgesia at superspinal level and analgesia at spinal cord level in rats.	2004 Dec	15569406
Reproducibility of patch tests: comparison of identical test allergens from different commercial sources.	2004 Jan	15059100
Hepatocyte proliferation in chronic hepatitis C: correlation with degree of liver disease and serum alpha-fetoprotein.	2004 Jun	15189269
Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdeydes unsaturated sesquiterpenes polygodial and drimanial in rats.	2004 Mar	14975683
[Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations].	2004 May	15218738
Investigations into the antinociceptive activity of Sapindus trifoliatus in various pain models.	2004 May	15142344
Long-term exposure to low levels of formaldehyde increases the number of tyrosine hydroxylase-immunopositive periglomerular cells in mouse main olfactory bulb.	2004 May 8	15064152
[Allergy to formaldehyde].	2004 Sep	15628056
Protein cross-linkage induced by formaldehyde derived from semicarbazide-sensitive amine oxidase-mediated deamination of methylamine.	2004 Sep	15128865
Use of the platelet reactivity index by Grotemeyer, platelet function analyzer, and retention test Homburg to monitor therapy with antiplatelet drugs.	2005	16149025
Transcriptomic analysis of F344 rat nasal epithelium suggests that the lack of carcinogenic response to glutaraldehyde is due to its greater toxicity compared to formaldehyde.	2005	16036858
Effect of formaldehyde gas exposure in a murine allergic contact hypersensitivity model.	2005	15803868
Supratentorial primitive neuroectodermal tumours of the brain: multidirectional differentiation does not influence prognosis. A clinicopathological report of 18 patients.	2005 Apr	15810952
Hypothalamo-pituitary-adrenal gland axis in mice inhaling toluene prior to low-level long-term exposure to formaldehyde.	2005 Mar	15805735
Redox imbalance induced by contact sensitizers triggers the maturation of dendritic cells.	2005 Mar	15737199
[Study on differential display genes of tolerant-damage of MRC-5 induced by formaldehyde of low dose].	2005 May	16111024
Vitamin E against oxidative damage caused by formaldehyde in frontal cortex and hippocampus: biochemical and histological studies.	2005 May	15820619
The interaction of trimethylamine dehydrogenase and electron-transferring flavoprotein.	2005 May 27	15760891
Detection of chlamydial bodies and antigens in the central nervous system of patients with multiple sclerosis.	2005 Oct 1	16136465

Patents

Sample Use Guides

In Vivo Use Guide

Formaldehyde 10% solution is applied topically once a day to affected areas.

Route of Administration: Topical

In Vitro Use Guide

Human lymphoblasts were exposed in vitro to various concentrations of formaldehyde (HCHO) in single and multiple treatment regimens to determine relative mutagenic efficiency. HCHO treatment resulted in a significant nonlinear increase in DNA-protein crosslinks at concentrations greater than 50 uM X 2 h, which correlated with the onset of significant toxicity in this cell line.

Name

Type

Language

Formaldehyde

Official Name

English

OXOMETHANE

Systematic Name

English

SUPERLYSOFORM

Common Name

English

FORMALDEHYDE [VANDF]

Common Name

English

PARAFORM

Common Name

English

FORMALDEHYDE [IARC]

Common Name

English

FORMALDEHYDE [MI]

Common Name

English

NSC-298885

Code

English

FORMALDEHYDE [II]

Common Name

English

METHANAL

Systematic Name

English

LYSOFORM

Common Name

English

FORMIC ALDEHYDE

Common Name

English

OXYMETHYLENE

Common Name

English

FORMALDEHYDE [INCI]

Common Name

English

METHYLENE OXIDE

Systematic Name

English

Classification Tree Code System Code

WHO-VATC

QP53AX19