U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula CH2O2
Molecular Weight 46.0254
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FORMIC ACID

SMILES

OC=O

InChI

InChIKey=BDAGIHXWWSANSR-UHFFFAOYSA-N
InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)

HIDE SMILES / InChI
Molecular Formula CH2O2
Molecular Weight 46.0254
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Formic acid is the simplest carboxylic acid. In nature, formic acid is found in the stings and bites of many insects of the order Hymenoptera, including bees and ants. The principal use of formic acid is as a preservative and antibacterial agent in livestock feed. When sprayed on fresh hay or other silage, it arrests certain decay processes and causes the feed to retain its nutritive value longer. In medicine 85% formic acid application is a safe, economical, and effective alternative in the treatment of common warts with few side-effects and good compliance.

Originator

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8429
EndWarts PEN

Approved Use

EndWarts PEN is a unique and effective wart treatment
PubMed

PubMed

TitleDatePubMed
Protection by short-chain fatty acids against 1-beta-D-arabinofuranosylcytosine-induced intestinal lesions in germfree mice.
1999 Apr
Human pendrin expressed in Xenopus laevis oocytes mediates chloride/formate exchange.
2000 Jan
Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene.
2000 Jul
Analysis of triacylglycerols with non-aqueous reversed-phase liquid chromatography and positive ion electrospray tandem mass spectrometry.
2001
Thermally labile domains in the collagen molecule.
2001 Apr
A comparison of salts for the crystallization of macromolecules.
2001 Feb
Characterization of the product ions from the collision-induced dissociation of argentinated peptides.
2001 Feb
Fully automated 96-well liquid-liquid extraction for analysis of biological samples by liquid chromatography with tandem mass spectrometry.
2001 Feb 1
Isoprenylcysteine carboxyl methyltransferase deficiency in mice.
2001 Feb 23
Synthesis, crystal structure, spectral studies, and catechol oxidase activity of trigonal bipyramidal Cu(II) complexes derived from a tetradentate diamide bisbenzimidazole ligand.
2001 Feb 26
Clostridium hungatei sp. nov., a mesophilic, N2-fixing cellulolytic bacterium isolated from soil.
2001 Jan
Solvent effects on oxygen-17 chemical shifts in methyl formate: linear solvation shift relationships.
2001 Jan
An organically modified silicate-based ethanol biosensor.
2001 Jan 1
Isomerism and solution dynamics of (90)Y-labeled DTPA--biomolecule conjugates.
2001 Jan-Feb
Crystallization and preliminary X-ray crystallographic analysis of RNase HIII from Bacillus subtilis.
2001 Mar
Purification and crystallization of the human RXRalpha ligand-binding domain-9-cisRA complex.
2001 Mar
Three-dimensional structure of human follicle-stimulating hormone.
2001 Mar
Increased bone turnover is associated with protein and energy metabolism in adolescents with sickle cell anemia.
2001 Mar
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
2001 Mar 1
SCO-spondin, a glycoprotein of the subcommissural organ/Reissner's fiber complex: evidence of a potent activity on neuronal development in primary cell cultures.
2001 Mar 1
Model of the 3-D structure of the GLUT3 glucose transporter and molecular dynamics simulation of glucose transport.
2001 Mar 1
Topology of the Na(+)/dicarboxylate cotransporter: the N-terminus and hydrophilic loop 4 are located intracellularly.
2001 Mar 9
Crystal structure of activated CheY. Comparison with other activated receiver domains.
2001 May 11
Patents

Patents

04061746
3
04337208
3
04345072
3
04350685
3
04400492
8
04555502
3
04639460
3
04661591
3
04665076
3
04757081
4
04829067
3
04870095
4
04871751
6
04886910
30
04894475
3
04916235
70
04929269
3
04965270
7
04978793
3
05037841
3
05041679
6
05053422
4
05087627
6
05099067
3
05101076
6
05130318
4
05130319
3
05141945
3
05143912
5
05147875
3
05153198
3
05153352
36
05173493
3
05175288
3
05198208
8
05198439
5
05200406
3
05221676
3
05232929
3
05236917
27
05245039
3
05246931
6
05246937
4
05250688
3
05258387
9
05266570
4
05274097
3
05286752
3
05288748
4
05290785
3
05292747
4
US20120123157
3
US2160064
3
US5206433
3
WO2013030162A1
3

Sample Use Guides

In Vivo Use Guide
Fifty patients received 85% formic acid application using a topical application/needle puncture technique every other day.
Route of Administration: Topical
In Vitro Use Guide
The adapted Aureobasidium pullulans strain could grow under the stress of 0.5 g/L furfural, 3 g/L HMF, 2g/L acetic acid, and 0.5 g/L formic acid, whereas the wild type did not.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:06:12 GMT 2023
Edited
by admin
on Fri Dec 15 15:06:12 GMT 2023
Record UNII
0YIW783RG1
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FORMIC ACID
FCC   FHFI   HSDB   INCI   MART.   MI   USP-RS   VANDF   WHO-DD  
INCI  
Official Name English
VARROMED COMPONENT FORMIC ACID
Brand Name English
FORMIC ACID [MART.]
Common Name English
FORMATE
Common Name English
FORMIC ACID [EP MONOGRAPH]
Common Name English
FORMICUM ACIDUM [HPUS]
Common Name English
FORMIC ACID [FHFI]
Common Name English
FORMIC ACID [MI]
Common Name English
FEMA NO. 2487
Code English
FORMIC ACID COMPONENT OF VARROMED
Brand Name English
METHANOIC ACID
Systematic Name English
FORMIC ACID [FCC]
Common Name English
FORMIC ACID [INCI]
Common Name English
Formic acid [WHO-DD]
Common Name English
FORMICUM ACIDUM
HPUS  
Common Name English
FORMIC ACID [EMA EPAR VETERINARY]
Common Name English
FORMIC ACID [VANDF]
Common Name English
FORMIC ACID [HSDB]
Common Name English
FORMIC ACID [USP-RS]
Common Name English
Classification Tree Code System Code
JECFA EVALUATION FORMIC ACID
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
EMA VETERINARY ASSESSMENT REPORTS VARROMED [AUTHORIZED]
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
DSLD 4255 (Number of products:2)
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
WHO-VATC QP53AG01
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
EPA PESTICIDE CODE 214900
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
CFR 21 CFR 186.1316
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
CFR 21 CFR 172.515
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
Code System Code Type Description
DRUG BANK
DB01942
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
PRIMARY
HSDB
1646
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
PRIMARY
CHEBI
15740
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
CONCEPT Industrial Aid
DAILYMED
0YIW783RG1
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
PRIMARY
EVMPD
SUB13916MIG
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
PRIMARY
FDA UNII
0YIW783RG1
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
PRIMARY
JECFA MONOGRAPH
1
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
PRIMARY
EPA CompTox
DTXSID2024115
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
PRIMARY
RS_ITEM_NUM
1283200
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
PRIMARY
SMS_ID
100000078507
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
PRIMARY
NCI_THESAURUS
C83719
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
PRIMARY
PUBCHEM
284
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
PRIMARY
MERCK INDEX
m5539
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
PRIMARY Merck Index
MESH
C030544
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
PRIMARY
CHEBI
30751
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
PRIMARY
WIKIPEDIA
FORMIC ACID
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
PRIMARY
CAS
64-18-6
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
PRIMARY
CHEBI
52343
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
PRIMARY
RXCUI
4537
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
PRIMARY RxNorm
ECHA (EC/EINECS)
200-579-1
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
PRIMARY
RXCUI
1362748
Created by admin on Fri Dec 15 15:06:12 GMT 2023 , Edited by admin on Fri Dec 15 15:06:12 GMT 2023
ALTERNATIVE
Related Record Type Details
Structure of ALUMINUM FORMATE
SALT/SOLVATE -> PARENT
Structure of AMMONIUM FORMATE
SALT/SOLVATE -> PARENT
Structure of POTASSIUM FORMATE
SALT/SOLVATE -> PARENT
Structure of MAGNESIUM FORMATE DIHYDRATE
SALT/SOLVATE -> PARENT
Structure of CALCIUM FORMATE
SALT/SOLVATE -> PARENT
Structure of SODIUM FORMATE
SALT/SOLVATE -> PARENT
Structure of MAGNESIUM FORMATE
SALT/SOLVATE -> PARENT
Structure of BUTETHAMINE FORMATE
SALT/SOLVATE -> PARENT
Structure of QUININE FORMATE
SALT/SOLVATE -> PARENT
Structure of NICKEL FORMATE
SALT/SOLVATE -> PARENT
Structure of FERRIC FORMATE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of FORMIC ACID
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966