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Cardiomyopathy

21

Unknown

2,596

Pain

619

Cancer

609

Hypertension

575

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US Previously Marketed

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Primary Target

Alanine aminotransferase 1

16

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

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reactive oxygen species metabolic process

16

ATP-sensitive potassium (KATP) channel

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Sulfonylurea receptor 2

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1921

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GlaxoSmithKline

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Heldt, W.|Rochleder, E.

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Chemical

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EPA CompTox

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BILE AND LIVER THERAPY

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PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS

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Liver therapy

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Showing 1 - 10 of 21 results

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LEVCROMAKALIM

RW7PN4BLDJ

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Status:

Investigational

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Sulfonylurea receptor 2

ATP-sensitive potassium (KATP) channel

Conditions:

Cromakalim is an ATP-sensitive potassium (KATP) channel opener, which was studied for the treatment of gastric ulcer, hypertension and preventing a cardiomyopathy. But the development of this drug was discontinued due to heart lesions found in monkey...

chronic toxicity studies.

CHRYSOPHANIC ACID

N1ST8V8RR2

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Dual specificity phosphatase Cdc25B

Cyclooxygenase-2

Cyclooxygenase-1

purinergic receptor activity

Protein-tyrosine phosphatase 1B

Japanese encephalitis virus

Conditions:

Japanese encephalitis

Diabetes mellitus

Ulcerative colitis

Chrysophanic acid (Chrysophanol) is a member of the anthraquinone family abundant in rhubarb, a widely used herb for obesity treatment in Traditional Korean Medicine. Chrysophanol has been shown to induce cell death in different types of cancer cells...

. Chrysophanol inhibits EGF-induced phosphorylation of EGFR and suppresses activation of AKT and mTOR/p70S6K. Chrysophanol also effectively suppresses breast cancer cell proliferation and facilitates chemosentivity through modulation of the NF-κB signaling pathway. A treatment of chrysophanol could reduce significantly the clinical signs and the levels of inflammatory mediators in a colitis model caused by DSS treatment. The anti-inflammatory activities of chrysophanol could be attributed, at least in part, to the inhibition of proinflammatory cytokine production (TNF-α and IL-6), COX-2, and iNOS protein expression. These effects of chrysophanol are caused by the inhibition of LPS-induced NF-κB activation, IκB-α degradation, and caspase-1 activation. These results provide experimental evidence showing that chrysophanol might prove useful in the treatment of inflammatory diseases.

ENOXOLONE

P540XA09DR

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Status:

US Previously Marketed

First marketed in 1921

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Alanine aminotransferase 1

reactive oxygen species metabolic process

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Conditions:

Radiodermatitis

Autoimmune hepatitis

Chronic hepatitis C

Chronic hepatitis C

Autoimmune hepatitis

Glycyrrhizic Acid is specific compound isolated from licorice plants. Ammonium Glycyrrhizate (also known as GLYCYRRHIZIN, AMMONIATED) is a salt, was investigated to be a safe and is used as ingredient in the formulation of makeup, fragrance, hair car...

e, skin care, shaving, personal hygiene and suntan products.

Foslevcromakalim sodium

YBT5QW7T2V

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Status:

Investigational

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Sulfonylurea receptor 2

ATP-sensitive potassium (KATP) channel

Conditions:

Cromakalim is an ATP-sensitive potassium (KATP) channel opener, which was studied for the treatment of gastric ulcer, hypertension and preventing a cardiomyopathy. But the development of this drug was discontinued due to heart lesions found in monkey...

chronic toxicity studies.

Foslevcromakalim

3U3LYD9HK6

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Status:

Investigational

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Sulfonylurea receptor 2

ATP-sensitive potassium (KATP) channel

Conditions:

Cromakalim is an ATP-sensitive potassium (KATP) channel opener, which was studied for the treatment of gastric ulcer, hypertension and preventing a cardiomyopathy. But the development of this drug was discontinued due to heart lesions found in monkey...

chronic toxicity studies.

CROMAKALIM

0G4X367WA3

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Status:

Investigational

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Sulfonylurea receptor 2

ATP-sensitive potassium (KATP) channel

Conditions:

Cromakalim is an ATP-sensitive potassium (KATP) channel opener, which was studied for the treatment of gastric ulcer, hypertension and preventing a cardiomyopathy. But the development of this drug was discontinued due to heart lesions found in monkey...

chronic toxicity studies.

POTASSIUM GLYCYRRHETINATE

5850KHR68O

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Status:

US Previously Marketed

First marketed in 1921

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Alanine aminotransferase 1

reactive oxygen species metabolic process

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Conditions:

Radiodermatitis

Autoimmune hepatitis

Chronic hepatitis C

Chronic hepatitis C

Autoimmune hepatitis

Glycyrrhizic Acid is specific compound isolated from licorice plants. Ammonium Glycyrrhizate (also known as GLYCYRRHIZIN, AMMONIATED) is a salt, was investigated to be a safe and is used as ingredient in the formulation of makeup, fragrance, hair car...

e, skin care, shaving, personal hygiene and suntan products.

MAGNESIUM GLYCYRRHIZINATE

4U2UBI61D7

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Status:

US Previously Marketed

First marketed in 1921

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Alanine aminotransferase 1

reactive oxygen species metabolic process

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Conditions:

Radiodermatitis

Autoimmune hepatitis

Chronic hepatitis C

Chronic hepatitis C

Autoimmune hepatitis

Glycyrrhizic Acid is specific compound isolated from licorice plants. Ammonium Glycyrrhizate (also known as GLYCYRRHIZIN, AMMONIATED) is a salt, was investigated to be a safe and is used as ingredient in the formulation of makeup, fragrance, hair car...

e, skin care, shaving, personal hygiene and suntan products.

ENOXOLONE SODIUM

E15REE98CW

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Status:

US Previously Marketed

First marketed in 1921

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Alanine aminotransferase 1

reactive oxygen species metabolic process

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Conditions:

Radiodermatitis

Autoimmune hepatitis

Chronic hepatitis C

Chronic hepatitis C

Autoimmune hepatitis

Glycyrrhizic Acid is specific compound isolated from licorice plants. Ammonium Glycyrrhizate (also known as GLYCYRRHIZIN, AMMONIATED) is a salt, was investigated to be a safe and is used as ingredient in the formulation of makeup, fragrance, hair car...

e, skin care, shaving, personal hygiene and suntan products.

AMMONIUM GLYCYRRHIZINATE TRIHYDRATE

78NEL3149I

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Status:

US Previously Marketed

First marketed in 1921

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Alanine aminotransferase 1

reactive oxygen species metabolic process

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Conditions:

Radiodermatitis

Autoimmune hepatitis

Chronic hepatitis C

Chronic hepatitis C

Autoimmune hepatitis

Glycyrrhizic Acid is specific compound isolated from licorice plants. Ammonium Glycyrrhizate (also known as GLYCYRRHIZIN, AMMONIATED) is a salt, was investigated to be a safe and is used as ingredient in the formulation of makeup, fragrance, hair car...

e, skin care, shaving, personal hygiene and suntan products.

Showing 1 - 10 of 21 results

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