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Approval Year

Unknown
139594
Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 11:43:54 UTC 2023
Edited
by admin
on Sat Dec 16 11:43:54 UTC 2023
Source Materials Class ORGANISM
Source Materials Type VIRUS
Organism Family Retroviridae
Organism Genus Lentivirus
Organism Species human immunodeficiency virus 1
Author NONE
Part WHOLE
Record UNII
859A956UY8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
Common Name English
HIV-1
Common Name English
Code System Code Type Description
FDA UNII
859A956UY8
Created by admin on Sat Dec 16 11:44:01 UTC 2023 , Edited by admin on Sat Dec 16 11:44:01 UTC 2023
PRIMARY
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HIV maturation inhibitor: Exhibited robust antiviral activity against a panel of HIV-1 clinical isolates, with a mean EC50 of 9 nM
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The observation of gastrointestinal intolerability and the emergence of resistant virus led to the cessation of development activities in favor of compounds with improved antiviral profiles.
EC50
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INHIBITOR->TARGET ORGANISM
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Upregulates innate immunity
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INHIBITOR->TARGET ORGANISM
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INHIBITOR->TARGET ORGANISM
Structure of STAVUDINE
INHIBITOR->TARGET ORGANISM
Structure of Thalassiolin B
INHIBITOR->TARGET ORGANISM
Structure of IXAZOMIB CITRATE
INHIBITOR->TARGET ORGANISM
Structure of TEMSAVIR
INHIBITOR->TARGET ORGANISM
Structure of TMC-310911
INHIBITOR->TARGET ORGANISM
Structure of 2-FLUORODIDEOXYCYTIDINE
INHIBITOR->TARGET ORGANISM
IN-VITRO
Structure of DAPIVIRINE
INHIBITOR->TARGET ORGANISM
Structure of THIAZOLOBENZIMIDAZOLE
INHIBITOR->TARGET ORGANISM
Structure of DS-003
INHIBITOR->TARGET ORGANISM
Structure of OBEFAZIMOD
INHIBITOR->TARGET ORGANISM
Structure of CENICRIVIROC
INHIBITOR->TARGET ORGANISM
Structure of DEXELVUCITABINE
INHIBITOR->TARGET ORGANISM
Structure of VERDINEXOR
INHIBITOR->TARGET ORGANISM
Structure of CL-197
INHIBITOR->TARGET ORGANISM
infected with HIV-luc/VSV-G (1 ng p24Gag).
EC50
VRC-01 (PRODUCED IN TOBACCO)
INHIBITOR->TARGET ORGANISM
Structure of NEVIRAPINE
INHIBITOR->TARGET ORGANISM
IC50 values (50% inhibitory concentration) ranged from 10-100 nM against laboratory and clinical isolates of HIV-1.
IC50
Structure of DARUNAVIR
INHIBITOR->TARGET ORGANISM
SEMZUVOLIMAB
INHIBITOR->TARGET ORGANISM
An Fc-aglycosylated, non–T-cell–depleting and CD4-specific humanized IgG1 derived from the parent murine B4, which binds to discontinuous, conformational epitopes on the HIV-receptor complex, including CD4 domain 1, and competitively blocks HIV entry
VRC07-523LS
INHIBITOR->TARGET ORGANISM
Structure of ELUNONAVIR
INHIBITOR->TARGET ORGANISM
Structure of LABUVIRTIDE
INHIBITOR->TARGET ORGANISM
VRC-01LS
INHIBITOR->TARGET ORGANISM
Structure of MK-2048
INHIBITOR->TARGET ORGANISM
EC50
Structure of Maraviroc
INHIBITOR->TARGET ORGANISM
Structure of Pirmitegravir
INHIBITOR->TARGET ORGANISM
Structure of TIPRANAVIR
INHIBITOR->TARGET ORGANISM
Tipranavir (TPV) is a non-peptidic HIV-1 protease inhibitor that inhibits the virus-specific processing of the viral Gag and Gag-Pol polyproteins in HIV-1 infected cells, thus preventing formation of mature virions.
Structure of STAMPIDINE
INHIBITOR->TARGET ORGANISM
Structure of ABACAVIR
INHIBITOR->TARGET ORGANISM
Structure of BRECANAVIR
INHIBITOR->TARGET ORGANISM
Structure of APLAVIROC
INHIBITOR->TARGET ORGANISM
HIVIG
INHIBITOR->TARGET ORGANISM
Zinlirvimab
INHIBITOR->TARGET ORGANISM
Structure of TNK-651
INHIBITOR->TARGET ORGANISM
Structure of MOZENAVIR
INHIBITOR->TARGET ORGANISM
Structure of ANCRIVIROC
INHIBITOR->TARGET ORGANISM
Structure of ELVUCITABINE
INHIBITOR->TARGET ORGANISM
Structure of GW-678248
INHIBITOR->TARGET ORGANISM
Preclinical assessment of GW678248 indicates that this compound potently inhibits wild-type (WT) and mutant human immunodeficiency virus type 1 (HIV-1) reverse transcriptase in biochemical assays, with 50% inhibitory concentrations (IC50s) between 0.8 and 6.8 nM. In HeLa CD4 MAGI cell culture virus replication assays, GW678248 has an IC50 of 21 nM against HIV-1 isogenic strains with single or double mutations known to be associated with NNRTI resistance, including L100I, K101E, K103N, V106A/I/M, V108I, E138K, Y181C, Y188C, Y188L, G190A/E, P225H, and P236L and various combinations. An IC50 of 86 nM was obtained with a mutant virus having V106I, E138K, and P236L mutations that resulted from serial passage of WT virus in the presence of GW678248.
Structure of RALTEGRAVIR
INHIBITOR->TARGET ORGANISM
Structure of TENOFOVIR DIPHOSPHATE
INHIBITOR->TARGET ORGANISM
Structure of TIVIRAPINE
INHIBITOR->TARGET ORGANISM
Structure of GW-695634
INHIBITOR->TARGET ORGANISM
Structure of AMPRENAVIR
INHIBITOR->TARGET ORGANISM
Structure of RITONAVIR
INHIBITOR->TARGET ORGANISM
Structure of CAPRAVIRINE
INHIBITOR->TARGET ORGANISM
Structure of CTP-518
INHIBITOR->TARGET ORGANISM
Structure of GS-9148
INHIBITOR->TARGET ORGANISM
Structure of BI-224436
INHIBITOR->TARGET ORGANISM
Structure of Thalassiolin A
INHIBITOR->TARGET ORGANISM
Structure of DOLUTEGRAVIR
INHIBITOR->TARGET ORGANISM
Structure of PPL-100
INHIBITOR->TARGET ORGANISM
Structure of EMTRICITABINE 5'-TRIPHOSPHATE
INHIBITOR->TARGET ORGANISM
HILTONOL
INHIBITOR->TARGET ORGANISM
Structure of CENSAVUDINE
INHIBITOR->TARGET ORGANISM
Structure of FOSDEVIRINE
INHIBITOR->TARGET ORGANISM
Structure of CABOTEGRAVIR
INHIBITOR->TARGET ORGANISM
Structure of BEVIRIMAT
INHIBITOR->TARGET ORGANISM
Structure of EMTRICITABINE
INHIBITOR->TARGET ORGANISM
Structure of LAMIVUDINE
INHIBITOR->TARGET ORGANISM
Structure of Ulonivirine
INHIBITOR->TARGET ORGANISM
Structure of VICRIVIROC
INHIBITOR->TARGET ORGANISM
Structure of SAQUINAVIR
INHIBITOR->TARGET ORGANISM
IC50
VRC-01
INHIBITOR->TARGET ORGANISM
Structure of DORAVIRINE
INHIBITOR->TARGET ORGANISM
Structure of RM-4848
INHIBITOR->TARGET ORGANISM
Upregulates innate immunity
Structure of PALINAVIR
INHIBITOR->TARGET ORGANISM
Structure of LOPINAVIR
INHIBITOR->TARGET ORGANISM
Structure of AMDOXOVIR
INHIBITOR->TARGET ORGANISM
Structure of FAROPENEM SODIUM
INHIBITOR->TARGET ORGANISM
PGT-121
INHIBITOR->TARGET ORGANISM
Structure of PF-04776548
INHIBITOR->TARGET ORGANISM
ALVIRCEPT SUDOTOX
INHIBITOR->TARGET ORGANISM
Structure of EFAVIRENZ
INHIBITOR->TARGET ORGANISM
OB-002
INHIBITOR->TARGET ORGANISM
DOES NOT ACTIVATE CCR5
IC50
Structure of VORINOSTAT
INHIBITOR->TARGET ORGANISM
LEFITOLIMOD
INHIBITOR->TARGET ORGANISM
Structure of LOBUCAVIR
INHIBITOR->TARGET ORGANISM
Structure of TROVIRDINE
INHIBITOR->TARGET ORGANISM
GRIFFITHSIN
INHIBITOR->TARGET ORGANISM
INHIBITS BINDING
ENFUVIRTIDE
INHIBITOR->TARGET ORGANISM
Structure of LASINAVIR
INHIBITOR->TARGET ORGANISM
Structure of LERSIVIRINE
INHIBITOR->TARGET ORGANISM
Structure of DROXINAVIR
INHIBITOR->TARGET ORGANISM
Structure of ATEVIRDINE
INHIBITOR->TARGET ORGANISM
Structure of TENOFOVIR ANHYDROUS
INHIBITOR->TARGET ORGANISM
EC50
Structure of TELINAVIR
INHIBITOR->TARGET ORGANISM
Structure of IQP-0528
INHIBITOR->TARGET ORGANISM
EC50
Structure of CLAFICAPAVIR
INHIBITOR->TARGET ORGANISM
Structure of ATAZANAVIR
INHIBITOR->TARGET ORGANISM
EC50
Structure of ISLATRAVIR ANHYDROUS
INHIBITOR->TARGET ORGANISM
Structure of DW-D-5
INHIBITOR->TARGET ORGANISM
Inhibits cytopathic effect
EC50
Structure of TALVIRALINE
INHIBITOR->TARGET ORGANISM
Structure of BILR-355
INHIBITOR->TARGET ORGANISM
The in vitro results showed that the EC50 of BILR 355 was 0.26 ng/ml (0.59 nM) against wild-type HIV-1 and ranged from 1.5 to 13 ng/ml (3.4 –29 nM) against clinically common single and double NNRTI mutations .
Structure of APRICITABINE
INHIBITOR->TARGET ORGANISM
Structure of DMP-323
INHIBITOR->TARGET ORGANISM
Structure of ZIDOVUDINE
INHIBITOR->TARGET ORGANISM
Structure of Depulfavirine
INHIBITOR->TARGET ORGANISM
Structure of OPAVIRALINE
INHIBITOR->TARGET ORGANISM
Structure of MAVORIXAFOR
INHIBITOR->TARGET ORGANISM
Structure of LENACAPAVIR
INHIBITOR->TARGET ORGANISM
GPI-2A
INHIBITOR->TARGET ORGANISM
Structure of EMIVIRINE
INHIBITOR->TARGET ORGANISM
Structure of NAVURIDINE
INHIBITOR->TARGET ORGANISM
Structure of Bavtavirine
INHIBITOR->TARGET ORGANISM
Structure of IDX-989
INHIBITOR->TARGET ORGANISM
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