Approval Year
Substance Class |
Structurally Diverse
Created
by
admin
on
Edited
Fri Jun 25 21:26:16 UTC 2021
by
admin
on
Fri Jun 25 21:26:16 UTC 2021
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Source Materials Class | ORGANISM |
Source Materials Type | VIRUS |
Organism Family | Retroviridae |
Organism Genus | Lentivirus |
Organism Species | Human immunodeficiency virus 1 |
Author | NONE |
Part | WHOLE |
Record UNII |
859A956UY8
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Record Status |
Validated (UNII)
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Record Version |
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-
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Common Name | English | ||
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Common Name | English |
Code System | Code | Type | Description | ||
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859A956UY8
Created by
admin on Fri Jun 25 21:26:16 UTC 2021 , Edited by admin on Fri Jun 25 21:26:16 UTC 2021
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INHIBITOR->TARGET ORGANISM |
Other
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM |
The observation of gastrointestinal intolerability and the emergence of resistant virus led to the cessation of development activities in favor of compounds with improved antiviral profiles.
EC50
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INHIBITOR->TARGET ORGANISM | |||
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TARGET ORGANISM->INHIBITOR | |||
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TARGET ORGANISM->INHIBITOR | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM |
IN-VITRO
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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TARGET ORGANISM->INHIBITOR | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR->TARGET ORGANISM |
An Fc-aglycosylated, non–T-cell–depleting and CD4-specific humanized IgG1 derived from the parent murine B4, which binds to discontinuous, conformational epitopes on the HIV-receptor complex, including CD4 domain 1, and competitively blocks HIV entry
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM |
EC50
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM |
Tipranavir (TPV) is a non-peptidic HIV-1 protease inhibitor that inhibits the virus-specific processing of the viral Gag and Gag-Pol polyproteins in HIV-1 infected cells, thus preventing formation of mature virions.
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TARGET ORGANISM->INHIBITOR | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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TARGET ORGANISM->INHIBITOR | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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TARGET ORGANISM->INHIBITOR | |||
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TARGET ORGANISM->INHIBITOR | |||
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INHIBITOR->TARGET ORGANISM |
INHIBITS BINDING
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INHIBITOR->TARGET ORGANISM | |||
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TARGET ORGANISM->INHIBITOR | |||
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INHIBITOR->TARGET ORGANISM |
EC50
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INHIBITOR->TARGET ORGANISM |
EC50
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INHIBITOR->TARGET ORGANISM |
The in vitro results showed that the EC50 of BILR 355 was 0.26 ng/ml (0.59 nM) against wild-type HIV-1 and ranged from 1.5 to 13 ng/ml (3.4 –29 nM) against clinically common single and double NNRTI mutations .
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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TARGET ORGANISM->INHIBITOR | |||
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INHIBITOR->TARGET ORGANISM | |||
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TARGET ORGANISM->INHIBITOR | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR->TARGET ORGANISM | |||
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INHIBITOR -> TARGET | |||
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INHIBITOR->TARGET ORGANISM |