Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C8H10FN3O3S |
Molecular Weight | 247.247 |
Optical Activity | ( - ) |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=NC(=O)N(C=C1F)[C@@H]2CS[C@H](CO)O2
InChI
InChIKey=XQSPYNMVSIKCOC-NTSWFWBYSA-N
InChI=1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6+/m0/s1
Molecular Formula | C8H10FN3O3S |
Molecular Weight | 247.247 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: Description was created based on several sources, including:
http://www.emory.edu/news/Releases/emtri/
Curator's Comment: Description was created based on several sources, including:
http://www.emory.edu/news/Releases/emtri/
Emtricitabine was discovered by Emory researchers Dr. Dennis C. Liotta, Dr. Raymond F. Schinazi and Dr. Woo-Baeg Choi and licensed to Triangle Pharmaceuticals by Emory University in 1996. Triangle was acquired by Gilead in 2003. Emtricitabine, marketed by Gilead as Emtriva, was first approved by the U.S. Food and Drug Administration in July 2003 for the treatment of HIV infection in combination with other antiretroviral agents. Emtricitabine, a synthetic nucleoside analog of cytidine, is phosphorylated by cellular enzymes to form emtricitabine 5'-triphosphate. Emtricitabine 5'-triphosphate inhibits the activity of the HIV-1 reverse transcriptase by competing with the natural substrate deoxycytidine 5'-triphosphate and by being incorporated into nascent viral DNA which results in chain termination.
CNS Activity
Originator
Sources: http://www.emory.edu/news/Releases/emtri/
Curator's Comment: Liotta, Schinazi and Choi (Emory University) and licensed to Triangle Pharmaceuticals by Emory University in 1996
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL247 |
0.31 µM [EC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | EMTRIVA Approved UseEMTRIVA is indicated, in combination with other antiretroviral agents, for the treatment of HIV-1 infection. Additional important information regarding the use of EMTRIVA for the treatment of HIV-1 Infection:
• EMTRIVA should not be coadministered with ATRIPLA™, TRUVADA®, or Lamivudine-containing products (see WARNINGS).
• In treatment-experienced patients, the use of EMTRIVA should be guided by laboratory testing and treatment history (see MICROBIOLOGY). Launch Date2003 |
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
1.8 μg/mL |
200 mg 1 times / day multiple, oral dose: 200 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
EMTRICITABINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
2.7 μg/mL |
5.6 mg/kg 1 times / day steady-state, oral dose: 5.6 mg/kg route of administration: Oral experiment type: STEADY-STATE co-administered: |
EMTRICITABINE plasma | Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
10 μg × h/mL |
200 mg 1 times / day multiple, oral dose: 200 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
EMTRICITABINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
12.6 μg × h/mL |
5.6 mg/kg 1 times / day steady-state, oral dose: 5.6 mg/kg route of administration: Oral experiment type: STEADY-STATE co-administered: |
EMTRICITABINE plasma | Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
10 h |
200 mg 1 times / day multiple, oral dose: 200 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
EMTRICITABINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
8.2 h |
5.6 mg/kg 1 times / day steady-state, oral dose: 5.6 mg/kg route of administration: Oral experiment type: STEADY-STATE co-administered: |
EMTRICITABINE plasma | Homo sapiens population: UNHEALTHY age: CHILD sex: FEMALE / MALE food status: UNKNOWN |
Funbound
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
96% |
200 mg 1 times / day multiple, oral dose: 200 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
EMTRICITABINE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
Doses
Dose | Population | Adverse events |
---|---|---|
200 mg 1 times / day steady, oral Recommended Dose: 200 mg, 1 times / day Route: oral Route: steady Dose: 200 mg, 1 times / day Co-administed with:: dolutegravir(50 mg) Sources: tenofovir disoproxil fumarate(300 mg) |
unhealthy, 26 - 42 years n = 717 Health Status: unhealthy Condition: HIV-1 Age Group: 26 - 42 years Sex: M+F Population Size: 717 Sources: |
Disc. AE: Headache... AEs leading to discontinuation/dose reduction: Headache (grade 2-5, 8 patients) Sources: |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Headache | grade 2-5, 8 patients Disc. AE |
200 mg 1 times / day steady, oral Recommended Dose: 200 mg, 1 times / day Route: oral Route: steady Dose: 200 mg, 1 times / day Co-administed with:: dolutegravir(50 mg) Sources: tenofovir disoproxil fumarate(300 mg) |
unhealthy, 26 - 42 years n = 717 Health Status: unhealthy Condition: HIV-1 Age Group: 26 - 42 years Sex: M+F Population Size: 717 Sources: |
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
---|---|---|---|
OverviewOther
Other Inhibitor | Other Substrate | Other Inducer |
---|---|---|
Drug as perpetrator
Drug as victim
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
no | ||||
no | ||||
no | ||||
no | ||||
no | ||||
yes |
PubMed
Title | Date | PubMed |
---|---|---|
Antiviral L-nucleosides specific for hepatitis B virus infection. | 2001 Jan |
|
New developments in anti-HIV chemotherapy. | 2001 Jan-Feb |
|
New antiretroviral agents. | 2001 Mar |
|
Treatment of chronic hepatitis B. | 2001 Nov |
|
Gateways to clinical trials. | 2002 Dec |
|
Gateways to clinical trials. | 2002 Nov |
|
New anti-HIV agents and targets. | 2002 Nov |
|
Inhibitory activity of dioxolane purine analogs on wild-type and lamivudine-resistant mutants of hepadnaviruses. | 2002 Sep |
|
FTC superiority over d4T in phase III trial. | 2002 Sep-Oct |
|
Entecavir, FTC, L-FMAU, LdT and others. | 2003 |
|
Treatment of chronic hepatitis B in the human immunodeficiency virus-infected patient: present and future. | 2003 Dec 15 |
|
Anti-HIV drug updates--three drugs on the near horizon. | 2003 Jan |
|
Gateways to clinical trials. | 2003 Jan-Feb |
|
FTC (Emtriva) approved. | 2003 Jul 25 |
|
Gateways to clinical trials. | 2003 Jun |
|
New antiretroviral drugs. | 2003 Mar |
|
FTC (emtricitabine, Emtriva). | 2003 Oct |
|
FDA notifications. NRTI Emtriva receives FDA approval. | 2003 Oct |
|
Assessment of the relative potency of emtricitabine and lamivudine. | 2003 Oct 1 |
|
New treatment of chronic hepatitis B. | 2004 |
|
Emtricitabine: a new nucleoside analogue for once-daily antiretroviral therapy. | 2004 Jan |
|
Efficacy and safety of emtricitabine vs stavudine in combination therapy in antiretroviral-naive patients: a randomized trial. | 2004 Jul 14 |
|
Emtricitabine: a once-daily nucleoside reverse transcriptase inhibitor. | 2004 Jun |
|
Initial therapy for human immunodeficiency virus: broadening the options. | 2004 Mar-Apr |
|
[New approaches in the treatment of hepatitis B]. | 2004 May 21 |
|
Antiretrovirals, Part II: focus on non-protease inhibitor antiretrovirals (NRTIs, NNRTIs, and fusion inhibitors). | 2004 Nov-Dec |
|
Pharmacokinetic properties of nucleoside/nucleotide reverse transcriptase inhibitors. | 2004 Sep 1 |
|
The pipeline: three to watch. | 2004 Summer |
Sample Use Guides
Emtriva® (emtricitabine) dosage.
Adult Patients (18 years of age and older):one 200 mg capsule administered once daily orally (Capsules). 240 mg (24 mL) administered once daily orally (Oral Solution).
Pediatric Patients (0–3 months of age): 3 mg/kg administered once daily orally (Oral Solution).
Pediatric Patients (3 months through 17 years): 6 mg/kg up to a maximum of 240 mg (24 mL) administered once daily orally (Oral Solution), for children weighing more than 33 kg who can swallow an intact capsule, one 200 mg capsule administered once daily orally (Capsules).
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23187937
emtricitabine EC50 0.99 μM (in vitro activity against HIV-2)
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:56:53 GMT 2023
by
admin
on
Fri Dec 15 15:56:53 GMT 2023
|
Record UNII |
G70B4ETF4S
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Brand Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Systematic Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Systematic Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
WHO-ESSENTIAL MEDICINES LIST |
6.4.2.3 (FTC/TEN)
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
WHO-ESSENTIAL MEDICINES LIST |
6.4.2.3 (EFV/FTC/TEN)
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
EMA ASSESSMENT REPORTS |
TRUVADA (AUTHORIZED: HIV INFECTIONS)
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
EMA ASSESSMENT REPORTS |
EMTRIVA (AUTHORIZED: HIV INFECTIONS)
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
WHO-ATC |
J05AF09
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
WHO-VATC |
QJ05AR09
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
EMA ASSESSMENT REPORTS |
DESCOVY (AUTHORIZED: HIV INFECTIONS )
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
NDF-RT |
N0000175459
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
NCI_THESAURUS |
C1557
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
WHO-ATC |
J05AR18
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
NDF-RT |
N0000175462
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
NDF-RT |
N0000175459
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
FDA ORPHAN DRUG |
569716
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
NDF-RT |
N0000009947
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
WHO-VATC |
QJ05AR06
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
EMA ASSESSMENT REPORTS |
STRIBILD (AUTHORIZED: HIV INFECTIONS)
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
EMA ASSESSMENT REPORTS |
EVIPLERA (AUTHORIZED: HIV INFECTIONS)
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
LIVERTOX |
NBK548261
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
WHO-VATC |
QJ05AR08
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
EMA ASSESSMENT REPORTS |
ATRIPLA (AUTHORIZED: HIV INFECTIONS)
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
WHO-ATC |
J05AR09
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
EMA ASSESSMENT REPORTS |
GENVOYA (AUTHORIZED: HIV INFECTIONS)
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
WHO-VATC |
QJ05AF09
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
WHO-ATC |
J05AR06
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
WHO-ATC |
J05AR03
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
FDA ORPHAN DRUG |
559316
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
NCI_THESAURUS |
C97452
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
EU-Orphan Drug |
EU/3/14/1420
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
WHO-ATC |
J05AR19
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
WHO-VATC |
QJ05AR03
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
WHO-ATC |
J05AR20
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
WHO-ESSENTIAL MEDICINES LIST |
6.4.2.1
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
WHO-ATC |
J05AR17
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
NDF-RT |
N0000175459
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
||
|
WHO-ATC |
J05AR08
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
7337
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | |||
|
DB00879
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | |||
|
DTXSID0040129
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | |||
|
60877
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | |||
|
100000091720
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | |||
|
C47509
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | |||
|
SUB01882MIG
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | |||
|
7822
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | |||
|
G70B4ETF4S
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | |||
|
m4892
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | Merck Index | ||
|
C122114
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | |||
|
KK-33
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | |||
|
CHEMBL885
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | |||
|
G70B4ETF4S
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | |||
|
31536
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | |||
|
EMTRICITABINE
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | Description: White to almost white, crystalline powder. Solubility: Freely soluble in methanol R and water R, practically insoluble in dichloromethane R. Category: Antiretroviral (Nucleoside Reverse Transcriptase Inhibitor). Storage: Emtricitabine should be kept in a tightly closed container. Additional information: Emtricitabine may exhibit polymorphism. | ||
|
1003
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | |||
|
143491-57-0
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | |||
|
1235106
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | |||
|
Emtricitabine
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | |||
|
EMTRICITABINE
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | |||
|
276237
Created by
admin on Fri Dec 15 15:56:54 GMT 2023 , Edited by admin on Fri Dec 15 15:56:54 GMT 2023
|
PRIMARY | RxNorm |
Related Record | Type | Details | ||
---|---|---|---|---|
|
TARGET ORGANISM->INHIBITOR |
|
||
|
TRANSPORTER -> INHIBITOR | |||
|
TRANSPORTER -> INHIBITOR | |||
|
TARGET -> INHIBITOR |
IC50
|
||
|
RACEMATE -> ENANTIOMER |
|
||
|
ENANTIOMER -> ENANTIOMER |
|
||
|
BINDER->LIGAND |
BINDING
|
Related Record | Type | Details | ||
---|---|---|---|---|
|
METABOLITE -> PARENT |
About 4% of dose
MINOR
URINE
|
||
|
METABOLITE -> PARENT |
9% of dose
MAJOR
URINE
|
||
|
METABOLITE ACTIVE -> PARENT |
|
Related Record | Type | Details | ||
---|---|---|---|---|
|
IMPURITY -> PARENT | |||
|
IMPURITY -> PARENT |
|
||
|
IMPURITY -> PARENT | |||
|
IMPURITY -> PARENT |
|
||
|
IMPURITY -> PARENT |
|
||
|
IMPURITY -> PARENT |
|
||
|
IMPURITY -> PARENT |
|
||
|
IMPURITY -> PARENT | |||
|
IMPURITY -> PARENT |
|
||
|
IMPURITY -> PARENT |
|
||
|
IMPURITY -> PARENT |
|
||
|
IMPURITY -> PARENT |
|
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |
|
Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
---|---|---|---|---|---|---|
Tmax | PHARMACOKINETIC |
|
|
|||
Biological Half-life | PHARMACOKINETIC |
|
|
|||