U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
139594
Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 11:30:42 GMT 2023
Edited
by admin
on Sat Dec 16 11:30:42 GMT 2023
Source Materials Class ORGANISM
Source Materials Type VIRUS
Source Materials Parent
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
Part POLYMERASE
Record UNII
A3Z87NSO0U
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 POLYMERASE
Common Name English
HIV-1 REVERSE TRANSCRIPTASE
Common Name English
HIV-1 RT
Common Name English
Code System Code Type Description
FDA UNII
A3Z87NSO0U
Created by admin on Sat Dec 16 11:30:45 GMT 2023 , Edited by admin on Sat Dec 16 11:30:45 GMT 2023
PRIMARY
Related Record Type Details
Structure of NAVURIDINE
INHIBITOR -> TARGET
Structure of AIC-292
INHIBITOR -> TARGET
Structure of STAVUDINE
INHIBITOR -> TARGET
Structure of ABACAVIR
INHIBITOR -> TARGET
Structure of DELAVIRDINE
INHIBITOR->TARGET ORGANISM
Delavirdine has demonstrated an IC50 of 0.26 micromolar against recombinant reverse transcriptase; at 3 micromolar, it halted the spread of virus in MT-4 cells and blocked replication of primary HIV-1 isolates in peripheral blood lymphocytes, including zidovudine-resistant variants.
Structure of DIDANOSINE
INHIBITOR -> TARGET
Structure of IQP-0528
INHIBITOR -> TARGET
Structure of RILPIVIRINE
INHIBITOR -> TARGET
Structure of L-738372
INHIBITOR -> TARGET
IC50
Structure of LOVIRIDE
INHIBITOR -> TARGET
Structure of ISLATRAVIR ANHYDROUS
INHIBITOR -> TARGET
Unique mode of action byblocking primer translocation without causing direct chain termination.
Structure of ATEVIRDINE
INHIBITOR -> TARGET
Structure of EMTRICITABINE 5'-TRIPHOSPHATE
INHIBITOR -> TARGET
Emtricitabine 5'-triphosphate inhibits the activity of the HIV-1 reverse transcriptase by competing with the natural substrate deoxycytidine 5'-triphosphate and by being incorporated into nascent viral DNA which results in chain termination.
Structure of TNK-651
INHIBITOR -> TARGET
Structure of ISLATRAVIR TRIPHOSPHATE
INHIBITOR -> TARGET
HIV-1 nucleoside reverse transcriptase translocation inhibitor
Structure of GW-678248
INHIBITOR -> TARGET
Structure of LAMIVUDINE
INHIBITOR -> TARGET
Structure of CAPRAVIRINE
INHIBITOR -> TARGET
Structure of TENOFOVIR DIPHOSPHATE
INHIBITOR -> TARGET
Structure of CL-197
INHIBITOR -> TARGET
Structure of Ulonivirine
INHIBITOR -> TARGET
Structure of FOSDEVIRINE
INHIBITOR -> TARGET
Structure of TALVIRALINE
INHIBITOR -> TARGET
Structure of Depulfavirine
INHIBITOR -> TARGET
Structure of GS-9148
INHIBITOR -> TARGET
Structure of TENOFOVIR ANHYDROUS
INHIBITOR -> TARGET
Structure of L-696229
INHIBITOR -> TARGET
IC50
Structure of ZIDOVUDINE
INHIBITOR -> TARGET
Structure of OPAVIRALINE
INHIBITOR -> TARGET
Structure of TIVIRAPINE
INHIBITOR -> TARGET
Structure of DPC-963
INHIBITOR -> TARGET
Structure of EFAVIRENZ
INHIBITOR -> TARGET
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 POLYMERASE
INHIBITOR -> TARGET
HIV-1 nucleoside reverse transcriptase translocation inhibitor
Structure of EMIVIRINE
INHIBITOR -> TARGET
Structure of TROVIRDINE
INHIBITOR -> TARGET
Structure of EMTRICITABINE
INHIBITOR -> TARGET
IC50
Structure of Bavtavirine
INHIBITOR -> TARGET
Structure of NEVIRAPINE
INHIBITOR -> TARGET
Structure of ETRAVIRINE
INHIBITOR -> TARGET
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966