Approval Year
Substance Class |
Structurally Diverse
Created
by
admin
on
Edited
Tue Apr 01 16:29:33 GMT 2025
by
admin
on
Tue Apr 01 16:29:33 GMT 2025
|
Source Materials Class | ORGANISM |
Source Materials Type | VIRUS |
Source Materials Parent | |
Part | polymerase |
Record UNII |
A3Z87NSO0U
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Record Status |
Validated (UNII)
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Record Version |
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-
Download
Name | Type | Language | ||
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Preferred Name | English | ||
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Common Name | English | ||
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Common Name | English |
Code System | Code | Type | Description | ||
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A3Z87NSO0U
Created by
admin on Tue Apr 01 16:29:33 GMT 2025 , Edited by admin on Tue Apr 01 16:29:33 GMT 2025
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR->TARGET ORGANISM |
Delavirdine has demonstrated an IC50 of 0.26 micromolar against recombinant reverse transcriptase; at 3 micromolar, it halted the spread of virus in MT-4 cells and blocked replication of primary HIV-1 isolates in peripheral blood lymphocytes, including zidovudine-resistant variants.
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
Unique mode of action byblocking primer translocation without causing direct chain termination.
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INHIBITOR -> TARGET |
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INHIBITOR->TARGET ORGANISM |
Non-nucleoside inhibitor
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INHIBITOR -> TARGET |
Emtricitabine 5'-triphosphate inhibits the activity of the HIV-1 reverse transcriptase by competing with the natural substrate deoxycytidine 5'-triphosphate and by being incorporated into nascent viral DNA which results in chain termination.
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
NNRTI
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
Non-nucleoside RT inhibitor
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
HIV-1 nucleoside reverse transcriptase translocation inhibitor
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |