U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Jun 26 22:44:46 UTC 2021
Edited
by admin
on Sat Jun 26 22:44:46 UTC 2021
Source Materials Class ORGANISM
Source Materials Type VIRUS
Source Materials Parent
Part POLYMERASE
Record UNII
A3Z87NSO0U
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 POLYMERASE
Common Name English
HIV-1 REVERSE TRANSCRIPTASE
Common Name English
HIV-1 RT
Common Name English
Code System Code Type Description
FDA UNII
A3Z87NSO0U
Created by admin on Sat Jun 26 22:44:47 UTC 2021 , Edited by admin on Sat Jun 26 22:44:47 UTC 2021
PRIMARY
Related Record Type Details
INHIBITOR -> TARGET
INHIBITOR->TARGET ORGANISM
Delavirdine has demonstrated an IC50 of 0.26 micromolar against recombinant reverse transcriptase; at 3 micromolar, it halted the spread of virus in MT-4 cells and blocked replication of primary HIV-1 isolates in peripheral blood lymphocytes, including zidovudine-resistant variants.
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET