HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 POLYMERASE

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Jun 26 22:44:46 UTC 2021` Edited by `admin` on `Sat Jun 26 22:44:46 UTC 2021`
Source Materials Class	ORGANISM
Source Materials Type	VIRUS
Source Materials Parent	`859A956UY8` HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
Part	POLYMERASE
Record UNII	A3Z87NSO0U
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 POLYMERASE

Common Name

English

HIV-1 REVERSE TRANSCRIPTASE

Common Name

English

HIV-1 RT

Common Name

English

Code System Code Type Description

FDA UNII

A3Z87NSO0U

Created by admin on Sat Jun 26 22:44:47 UTC 2021 , Edited by admin on Sat Jun 26 22:44:47 UTC 2021

PRIMARY

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DELAVIRDINE

INHIBITOR->TARGET ORGANISM

Comments:

Delavirdine has demonstrated an IC50 of 0.26 micromolar against recombinant reverse transcriptase; at 3 micromolar, it halted the spread of virus in MT-4 cells and blocked replication of primary HIV-1 isolates in peripheral blood lymphocytes, including zidovudine-resistant variants.