Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C15H20N2O3S2 |
Molecular Weight | 340.461 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC2=C(NC(=S)[C@H](CSC)N2C(=O)OC(C)C)C=C1
InChI
InChIKey=GWKIPRVERALPRD-ZDUSSCGKSA-N
InChI=1S/C15H20N2O3S2/c1-9(2)20-15(18)17-12-7-10(19-3)5-6-11(12)16-14(21)13(17)8-22-4/h5-7,9,13H,8H2,1-4H3,(H,16,21)/t13-/m0/s1
Molecular Formula | C15H20N2O3S2 |
Molecular Weight | 340.461 |
Charge | 0 |
Count |
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Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Talviraline (HBY 097) was developed as a nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (NNRTI) for the treatment of HIV Infections. Talviraline participated in a phase II clinical trial. It was found that the drug caused pronounced acute suppression of HIV-1 replication both in combination with zidovudine and alone. However, further development of the drug has been discontinued.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Patterns of resistance and cross-resistance to human immunodeficiency virus type 1 reverse transcriptase inhibitors in patients treated with the nonnucleoside reverse transcriptase inhibitor loviride. | 1998 Dec |
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Mutational analysis of trp-229 of human immunodeficiency virus type 1 reverse transcriptase (RT) identifies this amino acid residue as a prime target for the rational design of new non-nucleoside RT inhibitors. | 2000 May |
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:06:14 GMT 2023
by
admin
on
Fri Dec 15 16:06:14 GMT 2023
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Record UNII |
XZ4KT6MO4X
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C97453
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7521
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SUB10818MIG
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163451-80-7
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DB07885
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C90787
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169312-27-0
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3000493
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XZ4KT6MO4X
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100000083230
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CHEMBL430488
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DTXSID10168701
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TARGET ORGANISM->INHIBITOR |
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TARGET -> INHIBITOR |
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