Details
Stereochemistry | ACHIRAL |
Molecular Formula | C17H22N2O3 |
Molecular Weight | 302.3682 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOCN1C(=O)NC(=O)C(C(C)C)=C1CC2=CC=CC=C2
InChI
InChIKey=MLILORUFDVLTSP-UHFFFAOYSA-N
InChI=1S/C17H22N2O3/c1-4-22-11-19-14(10-13-8-6-5-7-9-13)15(12(2)3)16(20)18-17(19)21/h5-9,12H,4,10-11H2,1-3H3,(H,18,20,21)
Molecular Formula | C17H22N2O3 |
Molecular Weight | 302.3682 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
MKC-442 (6-benzyl-1-(ethoxymethyl)-5-isopropyl-uracil) is a highly potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). Emivirine structurally is a nucleoside analog (NRTI) molecule, but it functions as a non-nucleoside reverse transcriptase inhibitor (NNRTI). Emivirine had reached phase 3 clinical trials for the treatment of HIV-1 infections before its further development was stopped.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL247 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7694070 |
8.0 nM [IC50] |
PubMed
Title | Date | PubMed |
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Selective and synergistic inhibition of human immunodeficiency virus type 1 reverse transcriptase by a non-nucleoside inhibitor, MKC-442. | 1993 Oct |
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Differential activities of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives against different human immunodeficiency virus type 1 mutant strains. | 1995 Apr |
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Suppression of the breakthrough of human immunodeficiency virus type 1 (HIV-1) in cell culture by thiocarboxanilide derivatives when used individually or in combination with other HIV-1-specific inhibitors (i.e., TSAO derivatives). | 1995 Jun 6 |
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The inhibition of human immunodeficiency virus type 1 in vitro by a non-nucleoside reverse transcriptase inhibitor MKC-442, alone and in combination with other anti-HIV compounds. | 1995 Mar |
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Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication. | 1996 Aug |
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Synthesis and potent anti-HIV-1 activity of novel 6-benzyluracil analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine. | 1996 Jun 7 |
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Characteristics of the Pro225His mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase that appears under selective pressure of dose-escalating quinoxaline treatment of HIV-1. | 1997 Nov |
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Structure-based design of novel dihydroalkoxybenzyloxopyrimidine derivatives as potent nonnucleoside inhibitors of the human immunodeficiency virus reverse transcriptase. | 1998 Dec |
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A novel mutation (F227L) arises in the reverse transcriptase of human immunodeficiency virus type 1 on dose-escalating treatment of HIV type 1-infected cell cultures with the nonnucleoside reverse transcriptase inhibitor thiocarboxanilide UC-781. | 1998 Feb 10 |
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Synthesis and anti-HIV-1 activity of novel 2,3-dihydro-7H-thiazolo[3,2-a]pyrimidin-7-ones. | 1998 Jan 15 |
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Allosteric inhibitors against HIV-1 reverse transcriptase: design and synthesis of MKC-442 analogues having an omega-functionalized acyclic structure. | 1998 Jul |
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Preclinical studies on thiocarboxanilide UC-781 as a virucidal agent. | 1998 Jul 9 |
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A proline-to-histidine substitution at position 225 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) sensitizes HIV-1 RT to BHAP U-90152. | 1998 Jun |
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5-Alkyl-2-[(methylthiomethyl)thio]-6-(benzyl)-pyrimidin-4-(1H)-ones as potent non-nucleoside reverse transcriptase inhibitors of S-DABO series. | 1998 Jun 16 |
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N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea as a potent inhibitor of NNI-resistant and multidrug-resistant human immunodeficiency virus-1. | 1999 Dec 20 |
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Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants. | 1999 Nov 4 |
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Inhibition of human immunodeficiency virus type 1 replication in acutely and chronically infected cells by EM2487, a novel substance produced by a Streptomyces species. | 1999 Oct |
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Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors. | 2000 Apr 10 |
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Structure-activity relationship studies on potential non-nucleoside DABO-like inhibitors of HIV-1 reverse transcriptase. | 2000 Mar |
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Mutational analysis of trp-229 of human immunodeficiency virus type 1 reverse transcriptase (RT) identifies this amino acid residue as a prime target for the rational design of new non-nucleoside RT inhibitors. | 2000 May |
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Antiviral drugs: current state of the art. | 2001 Aug |
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Structure-activity relationship studies on new DABOS: effect of substitutions at pyrimidine C-5 and C-6 positions on anti-HIV-1 activity. | 2001 Jan |
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Three-drug combinations of emivirine and nucleoside reverse transcriptase inhibitors in vitro: long-term culture of HIV-1-infected cells and breakthrough viruses. | 2001 May |
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Dioxolane guanosine, the active form of the prodrug diaminopurine dioxolane, is a potent inhibitor of drug-resistant HIV-1 isolates from patients for whom standard nucleoside therapy fails. | 2002 Jan 1 |
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New developments in anti-HIV chemotherapy. | 2002 Jul 18 |
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New anti-HIV agents and targets. | 2002 Nov |
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Multiple pathways in the synthesis of new annelated analogues of 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (emivirine). | 2003 Aug 21 |
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In vitro activity of potential anti-poxvirus agents. | 2003 Jan |
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Gateways to clinical trials. | 2003 Jan-Feb |
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Synthesis of novel MKC-442 analogues with potent activities against HIV-1. | 2003 Jul |
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Gateways to clinical trials. | 2003 Oct |
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Synthesis and evaluation of new potential HIV-1 non-nucleoside reverse transcriptase inhibitors. New analogues of MKC-442 containing Michael acceptors in the C-6 position. | 2003 Oct 21 |
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Synthesis of furoannelated analogues of Emivirine (MKC-442). | 2004 Mar |
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Gateways to clinical trials. | 2004 May |
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4-benzyl- and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones, a new family of potent anti-HIV agents: optimization and in vitro evaluation against clinically important HIV mutant strains. | 2004 Oct 21 |
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Synthesis and evaluation of double-prodrugs against HIV. Conjugation of D4T with 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine)-type reverse transcriptase inhibitors via the SATE prodrug approach. | 2005 Feb 24 |
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Synthesis of 2-(aminocarbonylmethylthio)-1H-imidazoles as novel Capravirine analogues. | 2005 Jul 1 |
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5-Alkyl-2-alkylamino-6-(2,6-difluorophenylalkyl)-3,4-dihydropyrimidin-4(3H)-ones, a new series of potent, broad-spectrum non-nucleoside reverse transcriptase inhibitors belonging to the DABO family. | 2005 Mar 15 |
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Chemo- and regioselective functionalization of uracil derivatives. Applications to the synthesis of oxypurinol and emivirine. | 2006 Aug 17 |
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The design and synthesis of 9-phenylcyclohepta[d]pyrimidine-2,4-dione derivatives as potent non-nucleoside inhibitors of HIV reverse transcriptase. | 2006 Sep 7 |
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Functionalization of unprotected uracil derivatives using the halogen-magnesium exchange. | 2007 Apr 26 |
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Synthesis and anti-HIV-1 activity of new MKC-442 analogues with an alkynyl-substituted 6-benzyl group. | 2007 May |
|
Synthesis and anti-HIV-1 activity of 1-substiuted 6-(3-cyanobenzoyl) and [(3-cyanophenyl)fluoromethyl]-5-ethyl-uracils. | 2009 Sep |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:39:14 GMT 2023
by
admin
on
Fri Dec 15 15:39:14 GMT 2023
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Record UNII |
X87G8IX72O
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C97453
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EMIVIRINE
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CHEMBL35033
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C73147
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44143
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DTXSID80164437
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7961
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149950-60-7
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DB08188
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65013
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X87G8IX72O
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100000087260
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C083858
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SUB01880MIG
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KK-34
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Related Record | Type | Details | ||
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TARGET ORGANISM->INHIBITOR |
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TARGET -> INHIBITOR |
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Related Record | Type | Details | ||
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ACTIVE MOIETY |
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