U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 14:56:55 GMT 2023
Edited
by admin
on Sat Dec 16 14:56:55 GMT 2023
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
4180O0RM6K
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SEMZUVOLIMAB
INN  
Official Name English
DB4C7 MAB
Common Name English
MAB DB4C7
Common Name English
semzuvolimab [INN]
Common Name English
IMMUNOGLOBULIN G1 (298-HISTIDINE), ANTI-(HUMAN CD4 ANTIGEN) (HUMAN-MUS MUSCULUS CLONE DB4C7 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS CLONE DB4C7 .KAPPA.-CHAIN, DIMER
Common Name English
UB-421 (DB4C7 MAB)
Code English
UB421
Code English
UB-421
Code English
Code System Code Type Description
CAS
1888475-19-1
Created by admin on Sat Dec 16 14:56:55 GMT 2023 , Edited by admin on Sat Dec 16 14:56:55 GMT 2023
SUPERSEDED
INN
11685
Created by admin on Sat Dec 16 14:56:55 GMT 2023 , Edited by admin on Sat Dec 16 14:56:55 GMT 2023
PRIMARY
FDA UNII
4180O0RM6K
Created by admin on Sat Dec 16 14:56:55 GMT 2023 , Edited by admin on Sat Dec 16 14:56:55 GMT 2023
PRIMARY
NCI_THESAURUS
C188511
Created by admin on Sat Dec 16 14:56:55 GMT 2023 , Edited by admin on Sat Dec 16 14:56:55 GMT 2023
PRIMARY
CAS
2409099-32-5
Created by admin on Sat Dec 16 14:56:55 GMT 2023 , Edited by admin on Sat Dec 16 14:56:55 GMT 2023
PRIMARY
From To
1_22 1_96
1_145 1_201
1_221 3_218
1_227 2_227
1_230 2_230
1_262 1_322
1_368 1_426
2_22 2_96
2_145 2_201
2_221 4_218
2_262 2_322
2_368 2_426
3_23 3_92
3_138 3_198
4_23 4_92
4_138 4_198
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_101
N 2_101
Related Record Type Details
TARGET -> INHIBITOR
TARGET ORGANISM->INHIBITOR
An Fc-aglycosylated, non–T-cell–depleting and CD4-specific humanized IgG1 derived from the parent murine B4, which binds to discontinuous, conformational epitopes on the HIV-receptor complex, including CD4 domain 1, and competitively blocks HIV entry
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL