U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Approval Year

Substance Class Protein
Created
by admin
on Wed Apr 02 02:13:00 GMT 2025
Edited
by admin
on Wed Apr 02 02:13:00 GMT 2025
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
4180O0RM6K
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SEMZUVOLIMAB
INN  
Official Name English
UB-421
Preferred Name English
DB4C7 MAB
Common Name English
MAB DB4C7
Common Name English
semzuvolimab [INN]
Common Name English
IMMUNOGLOBULIN G1 (298-HISTIDINE), ANTI-(HUMAN CD4 ANTIGEN) (HUMAN-MUS MUSCULUS CLONE DB4C7 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS CLONE DB4C7 .KAPPA.-CHAIN, DIMER
Common Name English
UB-421 (DB4C7 MAB)
Code English
UB421
Code English
Code System Code Type Description
CAS
1888475-19-1
Created by admin on Wed Apr 02 02:13:00 GMT 2025 , Edited by admin on Wed Apr 02 02:13:00 GMT 2025
SUPERSEDED
INN
11685
Created by admin on Wed Apr 02 02:13:00 GMT 2025 , Edited by admin on Wed Apr 02 02:13:00 GMT 2025
PRIMARY
FDA UNII
4180O0RM6K
Created by admin on Wed Apr 02 02:13:00 GMT 2025 , Edited by admin on Wed Apr 02 02:13:00 GMT 2025
PRIMARY
NCI_THESAURUS
C188511
Created by admin on Wed Apr 02 02:13:00 GMT 2025 , Edited by admin on Wed Apr 02 02:13:00 GMT 2025
PRIMARY
CAS
2409099-32-5
Created by admin on Wed Apr 02 02:13:00 GMT 2025 , Edited by admin on Wed Apr 02 02:13:00 GMT 2025
PRIMARY
SMS_ID
300000042059
Created by admin on Wed Apr 02 02:13:00 GMT 2025 , Edited by admin on Wed Apr 02 02:13:00 GMT 2025
PRIMARY
From To
1_22 1_96
1_145 1_201
1_221 3_218
1_227 2_227
1_230 2_230
1_262 1_322
1_368 1_426
2_22 2_96
2_145 2_201
2_221 4_218
2_262 2_322
2_368 2_426
3_23 3_92
3_138 3_198
4_23 4_92
4_138 4_198
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_101
N 2_101
Related Record Type Details
TARGET -> INHIBITOR
TARGET ORGANISM->INHIBITOR
An Fc-aglycosylated, non–T-cell–depleting and CD4-specific humanized IgG1 derived from the parent murine B4, which binds to discontinuous, conformational epitopes on the HIV-receptor complex, including CD4 domain 1, and competitively blocks HIV entry
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_1] [2_1] N-TERMINUS PIDOLIC ACID SZB83O1W42
AMINO ACID REMOVAL [1_448] [2_448] C-TERMINUS LYSINE K3Z4F929H6
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL