Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Wed Apr 02 02:13:00 GMT 2025
by
admin
on
Wed Apr 02 02:13:00 GMT 2025
|
| Protein Type | MONOCLONAL ANTIBODY |
| Protein Sub Type | IGG1 |
| Sequence Origin | HUMANIZED MOUSE |
| Sequence Type | COMPLETE |
| Record UNII |
4180O0RM6K
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Official Name | English | ||
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Code | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
1888475-19-1
Created by
admin on Wed Apr 02 02:13:00 GMT 2025 , Edited by admin on Wed Apr 02 02:13:00 GMT 2025
|
SUPERSEDED | |||
|
11685
Created by
admin on Wed Apr 02 02:13:00 GMT 2025 , Edited by admin on Wed Apr 02 02:13:00 GMT 2025
|
PRIMARY | |||
|
4180O0RM6K
Created by
admin on Wed Apr 02 02:13:00 GMT 2025 , Edited by admin on Wed Apr 02 02:13:00 GMT 2025
|
PRIMARY | |||
|
C188511
Created by
admin on Wed Apr 02 02:13:00 GMT 2025 , Edited by admin on Wed Apr 02 02:13:00 GMT 2025
|
PRIMARY | |||
|
2409099-32-5
Created by
admin on Wed Apr 02 02:13:00 GMT 2025 , Edited by admin on Wed Apr 02 02:13:00 GMT 2025
|
PRIMARY | |||
|
300000042059
Created by
admin on Wed Apr 02 02:13:00 GMT 2025 , Edited by admin on Wed Apr 02 02:13:00 GMT 2025
|
PRIMARY |
| From | To |
|---|---|
| 1_22 | 1_96 |
| 1_145 | 1_201 |
| 1_221 | 3_218 |
| 1_227 | 2_227 |
| 1_230 | 2_230 |
| 1_262 | 1_322 |
| 1_368 | 1_426 |
| 2_22 | 2_96 |
| 2_145 | 2_201 |
| 2_221 | 4_218 |
| 2_262 | 2_322 |
| 2_368 | 2_426 |
| 3_23 | 3_92 |
| 3_138 | 3_198 |
| 4_23 | 4_92 |
| 4_138 | 4_198 |
| Glycosylation Type | MAMMALIAN |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_101 |
| N | 2_101 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
TARGET -> INHIBITOR |
|
||
|
TARGET ORGANISM->INHIBITOR |
An Fc-aglycosylated, non–T-cell–depleting and CD4-specific humanized IgG1 derived from the parent murine B4, which binds to discontinuous, conformational epitopes on the HIV-receptor complex, including CD4 domain 1, and competitively blocks HIV entry
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
ACTIVE MOIETY |
|
Structural Modifications
| Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
|---|---|---|---|---|---|---|
| AMINO_ACID_SUBSTITUTION | [1_1] [2_1] | N-TERMINUS | PIDOLIC ACID | SZB83O1W42 | ||
| AMINO ACID REMOVAL | [1_448] [2_448] | C-TERMINUS | LYSINE | K3Z4F929H6 |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
|
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| Molecular Formula | CHEMICAL |
|