TELINAVIR

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C33H44N6O5
Molecular Weight	604.7397
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)CN(C[C@@H](O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC(N)=O)NC(=O)C2=NC3=CC=CC=C3C=C2)C(=O)NC(C)(C)C

InChI

InChIKey=ZILOOGIOHVCEKS-HZFUHODCSA-N

InChI=1S/C33H44N6O5/c1-21(2)19-39(32(44)38-33(3,4)5)20-28(40)26(17-22-11-7-6-8-12-22)36-31(43)27(18-29(34)41)37-30(42)25-16-15-23-13-9-10-14-24(23)35-25/h6-16,21,26-28,40H,17-20H2,1-5H3,(H2,34,41)(H,36,43)(H,37,42)(H,38,44)/t26-,27-,28+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C33H44N6O5
Molecular Weight	604.7397
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9215651 | https://www.ncbi.nlm.nih.gov/pubmed/8619573

Telinavir (previously known as SC-52151) was developed as an anti-HIV aspartyl protease inhibitor for the treatment of HIV Infections. Telinavir participated in Phase I/II clinical study. In spite of the drug was well tolerated no antiviral activity was produced and further development of the drug was discontinued.

Approval Year

PubMed

Title	Date	PubMed
In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors.	1995 Apr 6	7700387
In vitro effect of alpha1-acid glycoprotein on the anti-human immunodeficiency virus (HIV) activity of the protease inhibitor CGP 61755: a comparative study with other relevant HIV protease inhibitors.	1997 May	9129067

Sample Use Guides

In Vivo Use Guide

Forty-nine patients received the elixir or self-emulsifying drug delivery system at a dosage of 750 mg three times daily or 1125 mg twice daily for 14 days

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:16:58 GMT 2023` Edited by `admin` on `Fri Dec 15 16:16:58 GMT 2023`
Record UNII	IZF55EH3CG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TELINAVIR

Official Name

English

SC-52151

Code

English

telinavir [INN]

Common Name

English

NSC-670881

Code

English

(2S)-N-[(1S,2R)-1-Benzyl-3-(3-tert-butyl-1-isobutylureido)-2-hydroxypropyl]-2-quinaldamidosuccinamide

Systematic Name

English

N-(3-((((1,1-DIMETHYLETHYL)AMINO)CARBONYL)(2-METHYLPROPYL)-AMINO)-2R-HYDROXY-1S-(PHENYLMETHYL)PROPYL)-2S-((2-QUINOLINYLCARBONYL)AMINO)BUTANEDIAMIDE

Systematic Name

English

BUTANEDIAMIDE, N1-((1S,2R)-3-((((1,1-DIMETHYLETHYL)AMINO)CARBONYL)(2-METHYLPROPYL)AMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-2-((2-QUINOLINYLCARBONYL)AMINO)-, (2S)-

Systematic Name

English

TELINAVIR [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C97366